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Background: Optimising stimulus parameters is important in maximising the efficacy of repetitive transcranial magnetic stimulation (rTMS) in treatment applications. RTMS over motor cortex has been reported as more effective in producing corticospinal inhibition when a monophasic rather than a biphasic stimulus waveform is used. However, non-optimal coil orientation and high intensities of monophasic rTMS may have influenced previous results.

Methods: In eight healthy subjects, we measured motor evoked potentials (MEPs) in a hand muscle after monophasic and biphasic rTMS (1 Hz for 15 min) over the motor cortex with the coil always in the optimal orientation. MEPs were evoked by both monophasic and biphasic stimuli.

Results: MEPs were initially significantly reduced after monophasic but not biphasic rTMS. However, a late reduction was seen after biphasic rTMS.

Limitations: These motor cortical findings may not be directly applicable to prefrontal rTMS.

Conclusions: This study confirms that low frequency rTMS with monophasic pulses produces more corticospinal inhibition than with biphasic pulses, even when the direction of current and intensity are as well-matched as possible.

Titel:	Stimulus waveform influences the efficacy of repetitive transcranial magnetic stimulation.
Autor/in / Beteiligte Person:	Taylor, JL ; Loo, CK
Link:	E-Journal im Bestand der UB Hagen?
Zeitschrift:	Journal of affective disorders, Jg. 97 (2007), Heft 1-3, S. 271-6
Veröffentlichung:	Amsterdam, Elsevier/North-Holland Biomedical Press., 2007
Medientyp:	academicJournal
ISSN:	0165-0327 (print)
DOI:	10.1016/j.jad.2006.06.027
Schlagwort:	Adult Electromyography Female Hand innervation Humans Male Median Nerve physiology Muscle, Skeletal innervation Neural Inhibition physiology Prefrontal Cortex physiology Pyramidal Tracts physiology Reference Values Sensory Thresholds physiology Treatment Outcome Evoked Potentials, Motor physiology Motor Cortex physiology Transcranial Magnetic Stimulation methods
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [J Affect Disord] 2007 Jan; Vol. 97 (1-3), pp. 271-6. <i>Date of Electronic Publication: </i>2006 Aug 02. MeSH Terms: Evoked Potentials, Motor / physiology ; Motor Cortex / physiology ; Transcranial Magnetic Stimulation / *methods ; Adult ; Electromyography ; Female ; Hand / innervation ; Humans ; Male ; Median Nerve / physiology ; Muscle, Skeletal / innervation ; Neural Inhibition / physiology ; Prefrontal Cortex / physiology ; Pyramidal Tracts / physiology ; Reference Values ; Sensory Thresholds / physiology ; Treatment Outcome Entry Date(s): Date Created: 20060805 Date Completed: 20070319 Latest Revision: 20090928 Update Code: 20231215

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Stimulus waveform influences the efficacy of repetitive transcranial magnetic stimulation.