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Coenzyme Q(10) (CoQ(10)) is incorporated in nanoliposomes composed of egg yolk phospholipid, cholesterol, and Tween 80. Atomic force microscopy, performed to characterize vesicle surface topology, shows some visible influence of CoQ(10) on the nanoliposomal structure. CoQ(10) incorporation can suppress the increase of the z-average diameter of nanoliposomes during storage for 8 months at 4 degrees C. The liposomal lipid peroxidation caused by Fe(III)/ascorbate is also significantly inhibited. Perturbation of acyl chain motion of lipids due to the presence of CoQ(10) in the bilayer is examined by fluorescence probe diphenyl-hexatriene and Raman spectroscopy. Fluorescence probe studies indicate that CoQ(10) incorporation results in the microviscosity increase of nanoliposomes. The steric structure of nanoliposomes reflected by Raman spectroscopy changes obviously and shows CoQ(10) content dependency. The order parameters for the lateral interaction between chains increase. The trans conformation decrease and the gauche conformation increase as the weight contents of CoQ(10) incorporation are at 1%, 5%, 10%, and 32.5%. However, the order parameters for the longitudinal interaction in chains was higher than that of pure nanoliposomes as the weight content of CoQ(10) is at 25%. Results suggest that CoQ(10)might intercalate between lipid molecules and perturb the bilayer structure.

Titel:	Effect of coenzyme Q(10) incorporation on the characteristics of nanoliposomes.
Autor/in / Beteiligte Person:	Xia, S ; Xu, S ; Zhang, X ; Zhong, F
Zeitschrift:	The journal of physical chemistry. B, Jg. 111 (2007-03-08), Heft 9, S. 2200-7
Veröffentlichung:	Washington, D.C. : American Chemical Society, c1997-, 2007
Medientyp:	academicJournal
ISSN:	1520-6106 (print)
DOI:	10.1021/jp066130x
Schlagwort:	Antioxidants chemistry Ascorbic Acid chemistry Coenzymes Egg Yolk metabolism Fluorescent Dyes pharmacology Lipid Bilayers chemistry Microscopy, Atomic Force Nanotechnology Oxidation-Reduction Particle Size Phospholipids chemistry Spectrometry, Fluorescence methods Ubiquinone chemistry Liposomes chemistry Nanoparticles chemistry Ubiquinone analogs & derivatives
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [J Phys Chem B] 2007 Mar 08; Vol. 111 (9), pp. 2200-7. <i>Date of Electronic Publication: </i>2007 Feb 09. MeSH Terms: Liposomes / chemistry ; Nanoparticles / chemistry ; Ubiquinone / *analogs & derivatives ; Antioxidants / chemistry ; Ascorbic Acid / chemistry ; Coenzymes ; Egg Yolk / metabolism ; Fluorescent Dyes / pharmacology ; Lipid Bilayers / chemistry ; Microscopy, Atomic Force ; Nanotechnology ; Oxidation-Reduction ; Particle Size ; Phospholipids / chemistry ; Spectrometry, Fluorescence / methods ; Ubiquinone / chemistry Substance Nomenclature: 0 (Antioxidants) ; 0 (Coenzymes) ; 0 (Fluorescent Dyes) ; 0 (Lipid Bilayers) ; 0 (Liposomes) ; 0 (Phospholipids) ; 1339-63-5 (Ubiquinone) ; EJ27X76M46 (coenzyme Q10) ; PQ6CK8PD0R (Ascorbic Acid) Entry Date(s): Date Created: 20070210 Date Completed: 20070607 Latest Revision: 20141120 Update Code: 20240513

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Effect of coenzyme Q(10) incorporation on the characteristics of nanoliposomes.