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In areas where malaria transmission is stable, infants are often born to mothers who had Plasmodium falciparum infections during pregnancy. A significant number become exposed to infected erythrocytes or soluble parasite products with subsequent fetal immune priming or tolerance in utero. We performed ELISA to asses IgG and IgM seropositivity rates against three PfEMP1 DBL-alpha domains from 42 maternal-cord paired samples obtained at delivery from a hyperendemic area in Gabon. IgG was present in up to 80% of the cord serum samples, while IgM was found in only 20% of the same samples. These levels were not dependent on the parity of the mother or the peripheral and placental infectious status. The presence of IgM against DBL-alpha domain in cord serum samples suggests that this component is able to cross the placental barrier and mount a fetal immune response.

Titel:	Prenatal immune responses to Plasmodium falciparum erythrocyte membrane protein 1 DBL-alpha domain in Gabon.
Autor/in / Beteiligte Person:	Tena-Tomás, C ; Bouyou-Akotet, MK ; Kendjo, E ; Kombila, M ; Kremsner, PG ; Kun, JF
Link:	View record at Springer (Volltext) E-Journal im Bestand der UB Hagen?
Zeitschrift:	Parasitology research, Jg. 101 (2007-09-01), Heft 4, S. 1045-50
Veröffentlichung:	Berlin : Springer International, c1987-, 2007
Medientyp:	academicJournal
ISSN:	0932-0113 (print)
DOI:	10.1007/s00436-007-0585-9
Schlagwort:	Animals Duffy Blood-Group System chemistry Duffy Blood-Group System genetics Duffy Blood-Group System metabolism Enzyme-Linked Immunosorbent Assay Female Fetal Blood parasitology Gabon Glutathione Transferase genetics Glutathione Transferase immunology Glutathione Transferase metabolism Humans Immunoglobulin G blood Immunoglobulin M blood Malaria, Falciparum diagnosis Malaria, Falciparum parasitology Maternal-Fetal Exchange Placenta Pregnancy Pregnancy Complications, Parasitic diagnosis Pregnancy Complications, Parasitic parasitology Protozoan Proteins chemistry Protozoan Proteins genetics Protozoan Proteins metabolism Recombinant Fusion Proteins genetics Recombinant Fusion Proteins immunology Recombinant Fusion Proteins metabolism Antibodies, Protozoan blood Duffy Blood-Group System immunology Fetal Blood immunology Malaria, Falciparum immunology Plasmodium falciparum immunology Pregnancy Complications, Parasitic immunology Protozoan Proteins immunology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Parasitol Res] 2007 Sep; Vol. 101 (4), pp. 1045-50. <i>Date of Electronic Publication: </i>2007 May 29. MeSH Terms: Antibodies, Protozoan / blood ; Duffy Blood-Group System / immunology ; Fetal Blood / immunology ; Malaria, Falciparum / immunology ; Plasmodium falciparum / immunology ; Pregnancy Complications, Parasitic / immunology ; Protozoan Proteins / *immunology ; Animals ; Duffy Blood-Group System / chemistry ; Duffy Blood-Group System / genetics ; Duffy Blood-Group System / metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Fetal Blood / parasitology ; Gabon ; Glutathione Transferase / genetics ; Glutathione Transferase / immunology ; Glutathione Transferase / metabolism ; Humans ; Immunoglobulin G / blood ; Immunoglobulin M / blood ; Malaria, Falciparum / diagnosis ; Malaria, Falciparum / parasitology ; Maternal-Fetal Exchange ; Placenta ; Pregnancy ; Pregnancy Complications, Parasitic / diagnosis ; Pregnancy Complications, Parasitic / parasitology ; Protozoan Proteins / chemistry ; Protozoan Proteins / genetics ; Protozoan Proteins / metabolism ; Recombinant Fusion Proteins / genetics ; Recombinant Fusion Proteins / immunology ; Recombinant Fusion Proteins / metabolism References: J Gynecol Obstet Biol Reprod (Paris). 1987;16(4):485-8. (PMID: 3305688) ; J Infect Dis. 2006 Jul 15;194(2):176-83. (PMID: 16779723) ; Ann Trop Med Parasitol. 1988 Apr;82(2):121-5. (PMID: 2460040) ; Afr J Med Med Sci. 1997 Sep-Dec;26(3-4):167-70. (PMID: 10456162) ; Am J Trop Med Hyg. 1991 Jul;45(1):57-64. (PMID: 1714245) ; J Immunol. 2002 Jan 1;168(1):356-64. (PMID: 11751981) ; Infect Immun. 2003 Mar;71(3):1242-6. (PMID: 12595438) ; Am J Reprod Immunol. 2001 Aug;46(2):169-79. (PMID: 11506082) ; Parasite Immunol. 1996 Oct;18(10):483-90. (PMID: 9226685) ; Int J Infect Dis. 2005 May;9(3):159-69. (PMID: 15840457) ; Am J Trop Med Hyg. 1996;55(1 Suppl):57-60. (PMID: 8702038) ; Infect Immun. 2005 Jun;73(6):3462-70. (PMID: 15908375) ; P N G Med J. 1992 Dec;35(4):303-5. (PMID: 1341092) ; Clin Exp Immunol. 1997 Nov;110(2):212-8. (PMID: 9367404) ; J Exp Med. 2004 Nov 1;200(9):1197-203. (PMID: 15520249) ; J Immunol. 1998 Mar 1;160(5):2523-30. (PMID: 9498798) ; Infect Immun. 2001 Dec;69(12):7603-9. (PMID: 11705939) ; Lancet. 2004 Jan 24;363(9405):283-9. (PMID: 14751701) ; Clin Pediatr (Phila). 1997 Jul;36(7):411-3. (PMID: 9241479) ; Parasite Immunol. 1995 Jan;17(1):1-10. (PMID: 7731730) ; Immunol Today. 2000 Feb;21(2):107-8. (PMID: 10652471) ; J Immunol. 2007 Mar 1;178(5):2770-7. (PMID: 17312120) ; Parasite Immunol. 2001 Feb;23(2):51-9. (PMID: 11240896) ; Infect Immun. 2005 Dec;73(12):7988-95. (PMID: 16299291) Substance Nomenclature: 0 (Antibodies, Protozoan) ; 0 (Duffy Blood-Group System) ; 0 (Immunoglobulin G) ; 0 (Immunoglobulin M) ; 0 (Protozoan Proteins) ; 0 (Recombinant Fusion Proteins) ; 0 (erythrocyte membrane protein 1, Plasmodium falciparum) ; EC 2.5.1.18 (Glutathione Transferase) Entry Date(s): Date Created: 20070530 Date Completed: 20080110 Latest Revision: 20181113 Update Code: 20240513

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Prenatal immune responses to Plasmodium falciparum erythrocyte membrane protein 1 DBL-alpha domain in Gabon.