Meningitis epidemics in Africa: a brief overview.
In: Vaccine, Jg. 25 Suppl 1 (2007-09-03), S. A3-7
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Zugriff:
Every year, meningococcal meningitis causes thousands of deaths within the meningitis belt in sub-Saharan African countries. Large epidemic waves occur with a periodicity of 5-12 years. The waves do correspond to molecular changes in the expression of capsular or subcapsular antigens, which allow the bug to spread in susceptible populations. Serogroup A remains the major killer, even if in 2002, serogroup W135 ST-11 emerged in Burkina Faso, causing an important epidemic. However, the surveillance in the following years has showed a decrease in the W135 incidence and a clear predominance of serogroup A. Moreover, a new serogroup A strain belonging to ST-2859 seems to emerge and does represent a new threat for the coming seasons. In a vaccine perspective, and especially in the context of the development of an A conjugate vaccine; it is the key to strengthen the surveillance systems and to include molecular epidemiology as a tool for monitoring the molecular evolution of Neisseria meningitidis in Africa.
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Meningitis epidemics in Africa: a brief overview.
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Autor/in / Beteiligte Person: | Teyssou, R ; Muros-Le Rouzic, E |
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Zeitschrift: | Vaccine, Jg. 25 Suppl 1 (2007-09-03), S. A3-7 |
Veröffentlichung: | Amsterdam, The Netherlands : Elsevier Science ; <i>Original Publication</i>: [Guildford, Surrey, UK] : Butterworths, [c1983-, 2007 |
Medientyp: | academicJournal |
ISSN: | 0264-410X (print) |
DOI: | 10.1016/j.vaccine.2007.04.032 |
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