A multi-channel femtoampere-sensitivity conductometric array for biosensing applications.
In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, Jg. Suppl (2006), S. 6489-92
academicJournal
Zugriff:
Rapid detection of pathogens using field deployable biosensors requires integrated sensing and data processing. Detection of low concentration of biological agents is possible using accurate and real-time signal characterization devices. This paper presents a multi-channel conductometric array that can detect and measure current up to femtoampere range. The architecture uses a novel semi-synchronous SigmaDelta modulation that allows measurement of ultra-small currents by using a hysteretic comparison technique. The architecture achieves higher energy efficiency over a conventional SigmaDelta by reducing the total switching cycles of the comparator. A 3 mm x 3 mm chip implementing a 42 channel potentiostat array has been prototyped in a 0.5 microm CMOS technology. Measured results show 10 bits of resolution, with a sensitivity of upto 50 fA of current. The power consumption of the potentiostat is 11 microW per channel at a sampling rate of 250 kHz. The multi-channel potentiostat has been integrated with a conductometric biosensor for field deployable applications. Results with a Bacillus Cereus based biosensor demonstrate the effectiveness of the potentiostat in characterizing different concentration levels of pathogens in realtime.
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A multi-channel femtoampere-sensitivity conductometric array for biosensing applications.
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Autor/in / Beteiligte Person: | Gore, A ; Chakrabartty, S ; Pal, S ; Alocilja, E |
Zeitschrift: | Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, Jg. Suppl (2006), S. 6489-92 |
Veröffentlichung: | Piscataway, NJ : IEEE Service Center, c2004-c2006., 2006 |
Medientyp: | academicJournal |
ISSN: | 1557-170X (print) |
DOI: | 10.1109/IEMBS.2006.260865 |
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