Rectal motion can reduce CTV coverage and increase rectal dose during prostate radiotherapy: A daily cone-beam CT study.
In: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, Jg. 90 (2009-03-01), Heft 3, S. 312-7
academicJournal
Zugriff:
Background and Purpose: Daily on-treatment verification cone-beam CT (CBCT) was used to study the effect of rectal motion on clinical target volume (CTV) coverage during prostate radiotherapy.
Material and Methods: CBCT scans were acquired from 15 patients immediately after daily treatment. From these images, the rectum was contoured allowing the analysis of rectal volume cross-sectional area (CSA) and the determination of rectal dose. Rectal wall motion was quantified as a surrogate measure of prostate displacement and CTV coverage was subjectively assessed.
Results: Rectal volume decreased over the treatment course in 13 patients (P<0.001). Rectal wall regions corresponding to the prostate base displayed the greatest motion; larger displacements were seen in patients with larger rectal planning volumes. CTV coverage was inadequate, at the prostate base only, in 38% of the fractions delivered to 4/7 patients with a large rectum at planning (>100 cm(3)). In patients with small rectum at planning (<50 cm(3)) up to 25% more rectal volume than predicted was included in the high-dose region.
Conclusions: Rectal motion during treatment in prostate cancer patients has implications for CTV coverage and rectal dose. Measures to ensure consistency in daily rectal volume or image-guided strategies should be considered.
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Rectal motion can reduce CTV coverage and increase rectal dose during prostate radiotherapy: A daily cone-beam CT study.
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Autor/in / Beteiligte Person: | Sripadam, R ; Stratford, J ; Henry, AM ; Jackson, A ; Moore, CJ ; Price, P |
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Zeitschrift: | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, Jg. 90 (2009-03-01), Heft 3, S. 312-7 |
Veröffentlichung: | Limerick : Elsevier Scientific Publishers ; <i>Original Publication</i>: Amsterdam : Elsevier Science Publishers, c1983-, 2009 |
Medientyp: | academicJournal |
ISSN: | 0167-8140 (print) |
DOI: | 10.1016/j.radonc.2008.07.031 |
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