The ordering of nucleotides in the DNA: strong pyrimidine-purine patterns near homooligomer tracts.
In: Journal of theoretical biology, Jg. 149 (1991-03-07), Heft 1, S. 21-42
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Zugriff:
Here, we study the frequencies of occurrence of homooligomers flanked by one base, XnU or UXn, where X = A, C, G, T and U not equal to X. Specifically, we search for preferences (or discriminations) in their nearest neighbor doublet, VV. Extensive analysis of the data base reveals striking patterns in such VVUXn or UXn VV oligomers (V = A, C, G, T). With very few exceptions, if the VV and Xn are composed of complementary nucleotides, those oligomers having a pyrimidine (Y)-purine (R) junction are preferred over those with an RY one. If the VV and Xn nucleotides are not complementary, the RY junction oligomers are preferred over their YR counterparts. These trends are observed consistently in eukaryotic and prokaryotic sequences. They are particularly striking in the YR greater than RY oligomers containing complementary nucleotides. The general preferences and discriminations described here are in the same direction as our previous results for homooligomer tracts. These recurrences, along with some additional universal "rules", aid in our understanding of the ordering of nucleotides in the DNA.
Titel: |
The ordering of nucleotides in the DNA: strong pyrimidine-purine patterns near homooligomer tracts.
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Autor/in / Beteiligte Person: | Nussinov, R |
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Zeitschrift: | Journal of theoretical biology, Jg. 149 (1991-03-07), Heft 1, S. 21-42 |
Veröffentlichung: | Amsterdam : Elsevier ; <i>Original Publication</i>: London., 1991 |
Medientyp: | academicJournal |
ISSN: | 0022-5193 (print) |
DOI: | 10.1016/s0022-5193(05)80069-4 |
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