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The recent introduction of high-end ultrasound equipment combined with recent contrast agents provides marked improvements in the characterization of focal liver lesions as previously reported by monocentric studies. The aim of the present study was to evaluate the diagnostic performance of Contrast-Enhanced Ultrasonography (CEUS) using SonoVue as well as its medico-economic value for characterization of focal liver lesions. These nodules were not characterized on previous CT or conventional sonography. This prospective multicentric study conducted in 15 French centres found diagnostic performances similar to those reported for CT and MRI, with a concordance rate of 84.5%, sensitivity greater than 80% and specificity greater than 90% for all types of lesions. Higher acceptance was found for CEUS compared to other imaging modalities. Economical assessment based on examination reimbursment and contrast agent cost showed a lower cost for contrast ultrasound versus CT and MRI. This French multicentric study confirmed the high diagnostic value of CEUS for focal liver lesion characterization and demonstrated a lower economical impact compared to other imaging modalities such as CT and MRI.

Titel:	[Real-time contrast-enhanced ultrasound in the evaluation of focal liver lesions: diagnostic efficacy and economical issues from a French multicentric study].
Autor/in / Beteiligte Person:	Tranquart, F ; Correas, JM ; Ladam Marcus, V ; Manzoni, P ; Vilgrain, V ; Aube, C ; Elmaleh, A ; Chami, L ; Claudon, M ; Cuilleron, M ; Diris, B ; Garibaldi, F ; Lucidarme, O ; Marion, D ; Beziat, C ; Rode, A ; Tasu, JP ; Trillaud, H ; Bleuzen, A ; Le Gouge, A ; Giraudeau, B ; Rusch, E
Zeitschrift:	Journal de radiologie, Jg. 90 (2009), Heft 1 Pt 2, S. 109-22
Veröffentlichung:	Paris, New York, : Masson., 2009
Medientyp:	academicJournal
ISSN:	0221-0363 (print)
DOI:	10.1016/s0221-0363(09)70089-7
Schlagwort:	Adolescent Adult Biopsy Carcinoma, Hepatocellular diagnosis Confidence Intervals Data Interpretation, Statistical Diagnosis, Differential Focal Nodular Hyperplasia diagnosis France Humans Liver pathology Liver Diseases diagnostic imaging Liver Neoplasms diagnosis Liver Neoplasms pathology Liver Neoplasms secondary Magnetic Resonance Imaging economics Magnetic Resonance Imaging methods Patient Selection Prospective Studies Sensitivity and Specificity Tomography, X-Ray Computed economics Tomography, X-Ray Computed methods Ultrasonography economics Carcinoma, Hepatocellular diagnostic imaging Contrast Media Focal Nodular Hyperplasia diagnostic imaging Hemangioma diagnostic imaging Liver Neoplasms diagnostic imaging Phospholipids Sulfur Hexafluoride Ultrasonography methods
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: French Transliterated Title: Echographie de contraste temps réel dans la prise en charge diagnostique des lésions nodulaires hépatiques: évaluation des performances diagnostiques et de l'impact économique sur une étude multicentrique française. Publication Type: Comparative Study; Evaluation Study; Journal Article; Multicenter Study Language: French [J Radiol] 2009 Jan; Vol. 90 (1 Pt 2), pp. 109-22. MeSH Terms: Contrast Media* ; Phospholipids* ; Sulfur Hexafluoride* ; Carcinoma, Hepatocellular / diagnostic imaging ; Focal Nodular Hyperplasia / diagnostic imaging ; Hemangioma / diagnostic imaging ; Liver Neoplasms / diagnostic imaging ; Ultrasonography / *methods ; Adolescent ; Adult ; Biopsy ; Carcinoma, Hepatocellular / diagnosis ; Confidence Intervals ; Data Interpretation, Statistical ; Diagnosis, Differential ; Focal Nodular Hyperplasia / diagnosis ; France ; Humans ; Liver / pathology ; Liver Diseases / diagnostic imaging ; Liver Neoplasms / diagnosis ; Liver Neoplasms / pathology ; Liver Neoplasms / secondary ; Magnetic Resonance Imaging / economics ; Magnetic Resonance Imaging / methods ; Patient Selection ; Prospective Studies ; Sensitivity and Specificity ; Tomography, X-Ray Computed / economics ; Tomography, X-Ray Computed / methods ; Ultrasonography / economics Substance Nomenclature: 0 (Contrast Media) ; 0 (Phospholipids) ; 0 (contrast agent BR1) ; WS7LR3I1D6 (Sulfur Hexafluoride) Entry Date(s): Date Created: 20090213 Date Completed: 20090515 Latest Revision: 20191210 Update Code: 20240513

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[Real-time contrast-enhanced ultrasound in the evaluation of focal liver lesions: diagnostic efficacy and economical issues from a French multicentric study].