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Introduction: This study was conducted to determine the degree to which the clinical practice concerning computed tomographies (CTs) with iodinated contrast media in patients with lung cancer was in accordance with ESUR international guidelines. Lung cancer is treatable with platinum-based cytostatic drugs, which can be nephrotoxic. According to the ESUR s guidelines this adds to the risk of developing contrast-induced nephropathy.

Material and Methods: A retrospective study of lung cancer patients at Hillerød Hospital.

Inclusion Criteria: Patients in current treatment with platinum-based cytostatic drugs up to and including 20 Sept. 06 who had undergone an elective CT with iodinated contrast media. A total of 51 patients where included. P-creatinine and other potential risk factors for development of contrast-induced nephropathy were collected.

Results: In 31.4% of the patients included, P-creatinine was measured no earlier than seven days prior to their CT. 43.1% of the patients included had received a platinum-based cytostatic drug after the latest measurement of their P-creatinine prior to their CT scan. 45.1% of the patients received a platinum-based cytostatic 14 days or less before CT scan. 66.7% had additional risk factors. None needed nephrologic assistance.

Conclusion: Significant deviations were found between the clinical practice and ESUR international guidelines covering prevention of contrast-induced nephropathy. This study has led to changes in the guidelines and clinical practice regarding contrast-induced nephropathy at Hillerød Hosipital. Now all elective patients have P-creatinine measured no more than seven days prior to CT with iodinated contrast media.

Titel:	[Delay in implementation of international guidelines for computed tomographies with iodinated contrast media].
Autor/in / Beteiligte Person:	Holländer, C
Zeitschrift:	Ugeskrift for laeger, Jg. 171 (2009-04-20), Heft 17, S. 1400-4
Veröffentlichung:	Copenhagen : Den Alm Danske Laegerforening, 2009
Medientyp:	academicJournal
ISSN:	1603-6824 (electronic)
Schlagwort:	Antineoplastic Agents adverse effects Antineoplastic Agents therapeutic use Carboplatin adverse effects Carboplatin therapeutic use Cisplatin adverse effects Cisplatin therapeutic use Creatinine blood Guideline Adherence Humans Iopamidol adverse effects Lung Neoplasms diagnostic imaging Lung Neoplasms drug therapy Practice Patterns, Physicians' Retrospective Studies Risk Factors Contrast Media adverse effects Iohexol adverse effects Iopamidol analogs & derivatives Kidney Diseases chemically induced Practice Guidelines as Topic Tomography, X-Ray Computed
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: Danish Transliterated Title: Forsinket implementering af internationale retningslinjer for computertomografi med iodholdigt kontraststof . Publication Type: Journal Article Language: Danish [Ugeskr Laeger] 2009 Apr 20; Vol. 171 (17), pp. 1400-4. MeSH Terms: Practice Guidelines as Topic* ; Tomography, X-Ray Computed* ; Contrast Media / adverse effects ; Iohexol / adverse effects ; Iopamidol / analogs & derivatives ; Kidney Diseases / chemically induced ; Antineoplastic Agents / adverse effects ; Antineoplastic Agents / therapeutic use ; Carboplatin / adverse effects ; Carboplatin / therapeutic use ; Cisplatin / adverse effects ; Cisplatin / therapeutic use ; Creatinine / blood ; Guideline Adherence ; Humans ; Iopamidol / adverse effects ; Lung Neoplasms / diagnostic imaging ; Lung Neoplasms / drug therapy ; Practice Patterns, Physicians' ; Retrospective Studies ; Risk Factors Substance Nomenclature: 0 (Antineoplastic Agents) ; 0 (Contrast Media) ; 17E17JBP8L (iomeprol) ; 4419T9MX03 (Iohexol) ; AYI8EX34EU (Creatinine) ; BG3F62OND5 (Carboplatin) ; JR13W81H44 (Iopamidol) ; Q20Q21Q62J (Cisplatin) Entry Date(s): Date Created: 20090506 Date Completed: 20090511 Latest Revision: 20161125 Update Code: 20231215

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[Delay in implementation of international guidelines for computed tomographies with iodinated contrast media].