[Peptide hydrolase activity in rabbit brain subcellular fractions under conditions of adrenalectomy and administration of hydrocortisone and ACTH].
In: Ukrains'kyi biokhimichnyi zhurnal, Jg. 49 (1977-07-01), Heft 4, S. 92-6
academicJournal
Zugriff:
Adrenalectomy and administration of hydrocortisone and ACTH are shown to induce no changes in the total activity of neutral peptide-hydrolase in both homogenates and brain subcellular fractions. The absence of adrenalectomy and hormone administration effect on the total peptide-hydrolase activity in homogenates is established simultaneously with its essential changes in the brain subcellular fractions. A decrease in the enzymic activity of the mitochondrial-lysosomal fraction (MLF) following adrenalectomy is observed side by side with its increase in a soluble fraction. Hydrocortisone and ACTH administration cause an increase in the acid peptide-hydrolase activity in MLF and its decrease in the brain soluble and microsomal fractions of adrenalectomized rabbits. The degree of solubilization of MLF acid and neutral peptide-hydrolase by detergent triton X-100 after adrenalectomy is increased. Hydrocortisone and ACTH administration, on the contrary, decrease a degree of solubilization of the brain MLF peptide-hydrolase in adrenalectomized animals.
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[Peptide hydrolase activity in rabbit brain subcellular fractions under conditions of adrenalectomy and administration of hydrocortisone and ACTH].
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Autor/in / Beteiligte Person: | Kalins' ka, LM ; AIa, Mestechkina |
Zeitschrift: | Ukrains'kyi biokhimichnyi zhurnal, Jg. 49 (1977-07-01), Heft 4, S. 92-6 |
Veröffentlichung: | Kyiv : Izdatelstvo Naukova Dumka, 1977 |
Medientyp: | academicJournal |
ISSN: | 0041-610X (print) |
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