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The SWI/SNF complex remodels nucleosomes, allowing RNA Polymerase II access to the HIV-1 proviral DNA. It has not been determined which SWI/SNF complex (BAF or PBAF) remodels nucleosomes at the transcription start site. These complexes differ in only three subunits and determining which subunit(s) is required could explain the regulation of Tat activated transcription. We show that PBAF is required for chromatin remodeling at the nuc-1 start site and transcriptional elongation. We find that Baf200 is required to ensure activation at the LTR level and for viral production. Interestingly, the BAF complex was observed on the LTR whereas PBAF was present on both LTR and Env regions. We found that Tat activated transcription facilitates removal of histones H2A and H2B at the LTR, and that the FACT complex may be responsible for their removal. Finally, the BAF complex may play an important role in regulating splicing of the HIV-1 genome.

Titel:	Transcription through the HIV-1 nucleosomes: effects of the PBAF complex in Tat activated transcription.
Autor/in / Beteiligte Person:	Easley, R ; Carpio, L ; Dannenberg, L ; Choi, S ; Alani, D ; Van Duyne, R ; Guendel, I ; Klase, Z ; Agbottah, E ; Kehn-Hall, K ; Kashanchi, F
Link:	Full Text Finder (Volltext)
Zeitschrift:	Virology, Jg. 405 (2010-09-30), Heft 2, S. 322-33
Veröffentlichung:	New York, Academic Press., 2010
Medientyp:	academicJournal
ISSN:	1096-0341 (electronic)
DOI:	10.1016/j.virol.2010.06.009
Schlagwort:	Cell Line Cells, Cultured Chromatin metabolism Chromatin Assembly and Disassembly HIV Long Terminal Repeat genetics HIV-1 ultrastructure Humans Leukocytes, Mononuclear virology Nucleosomes genetics Chromosomal Proteins, Non-Histone metabolism Gene Expression Regulation, Viral HIV-1 metabolism Nucleosomes metabolism Transcription Factors metabolism Transcriptional Activation tat Gene Products, Human Immunodeficiency Virus metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Language: English [Virology] 2010 Sep 30; Vol. 405 (2), pp. 322-33. MeSH Terms: Gene Expression Regulation, Viral* ; Transcriptional Activation* ; Chromosomal Proteins, Non-Histone / metabolism ; HIV-1 / metabolism ; Nucleosomes / metabolism ; Transcription Factors / metabolism ; tat Gene Products, Human Immunodeficiency Virus / *metabolism ; Cell Line ; Cells, Cultured ; Chromatin / metabolism ; Chromatin Assembly and Disassembly ; HIV Long Terminal Repeat / genetics ; HIV-1 / ultrastructure ; Humans ; Leukocytes, Mononuclear / virology ; Nucleosomes / genetics References: Retrovirology. 2009 May 19;6:47. (PMID: 19454010) ; J Virol. 1993 Nov;67(11):6365-78. (PMID: 8411338) ; Cell. 1998 Jan 9;92(1):105-16. (PMID: 9489704) ; Genes Dev. 1992 Apr;6(4):655-66. (PMID: 1559613) ; EMBO J. 1991 Dec;10(13):4189-96. (PMID: 1756726) ; J Virol. 2002 Dec;76(23):12349-54. (PMID: 12414976) ; Science. 1995 Jan 27;267(5197):531-6. (PMID: 7824954) ; Curr Opin Genet Dev. 2002 Feb;12(1):73-9. (PMID: 11790558) ; Nat Cell Biol. 2004 Jan;6(1):73-7. (PMID: 14661024) ; EMBO J. 2006 Apr 19;25(8):1690-9. (PMID: 16601680) ; J Biol Chem. 2000 Dec 22;275(51):40463-70. (PMID: 11013263) ; Mol Cell Biol. 2006 Jan;26(1):250-60. (PMID: 16354696) ; Cell. 2002 Feb 22;108(4):475-87. (PMID: 11909519) ; Nature. 2005 Dec 22;438(7071):1181-5. (PMID: 16372014) ; Mol Cell Biol. 2002 Jul;22(14):5141-56. (PMID: 12077342) ; J Virol. 2004 Jul;78(13):6883-90. (PMID: 15194764) ; J Biol Chem. 2006 Aug 18;281(33):23297-301. (PMID: 16766522) ; Mol Cell Biol. 2004 Jan;24(1):389-97. (PMID: 14673171) ; Cell. 1990 Nov 16;63(4):791-802. (PMID: 2225077) ; Mol Cell Biol. 2002 Oct;22(20):6979-92. (PMID: 12242279) ; J Biol Chem. 2006 Jul 21;281(29):19960-8. (PMID: 16687403) ; Retrovirology. 2008 Jan 28;5:8. (PMID: 18226242) ; J Virol. 2006 Apr;80(7):3189-204. (PMID: 16537587) ; J Virol. 1995 Sep;69(9):5337-44. (PMID: 7636977) ; Nature. 1999 Jul 15;400(6741):284-8. (PMID: 10421373) ; Gene Expr. 1992;2(4):391-407. (PMID: 1282057) ; AIDS. 1997 Mar;11(3):297-303. (PMID: 9147420) ; J Mol Biol. 1995 Jul 7;250(2):169-80. (PMID: 7608968) ; Proc Natl Acad Sci U S A. 1991 May 1;88(9):4045-9. (PMID: 2023953) ; Retrovirology. 2006 Aug 07;3:48. (PMID: 16893449) ; Cell. 1989 Oct 20;59(2):283-92. (PMID: 2553266) ; Nat Struct Mol Biol. 2006 Jan;13(1):22-9. (PMID: 16341228) ; J Virol. 1991 Dec;65(12):6790-9. (PMID: 1942252) ; J Virol. 1996 Aug;70(8):5503-10. (PMID: 8764062) ; EMBO J. 2002 Apr 2;21(7):1764-74. (PMID: 11927560) ; EMBO J. 2003 Apr 15;22(8):1846-56. (PMID: 12682017) ; Genes Dev. 2005 Jul 15;19(14):1662-7. (PMID: 15985610) ; J Biol Chem. 2005 Dec 23;280(51):41789-92. (PMID: 16263726) ; Nat Struct Mol Biol. 2005 Feb;12(2):160-6. (PMID: 15643425) ; Mol Cell. 2002 Mar;9(3):541-52. (PMID: 11931762) ; Genes Dev. 2002 Oct 1;16(19):2509-17. (PMID: 12368262) ; Nucleic Acids Res. 1992 Sep 11;20(17):4673-4. (PMID: 1408778) ; Science. 2003 Aug 22;301(5636):1090-3. (PMID: 12934006) ; Retrovirology. 2006 Aug 09;3:49. (PMID: 16899112) ; J Biol Chem. 1997 Mar 14;272(11):6951-8. (PMID: 9054383) ; Chromosoma. 1999 Apr;108(1):10-25. (PMID: 10199952) ; Cell. 1981 Nov;27(1 Pt 2):45-55. (PMID: 6276024) ; Retrovirology. 2006 Aug 05;3:47. (PMID: 16889668) ; EMBO J. 1993 Aug;12(8):3249-59. (PMID: 8344262) ; J Biol Chem. 1989 Nov 5;264(31):18457-62. (PMID: 2478545) ; EMBO J. 1996 Mar 1;15(5):1112-20. (PMID: 8605881) ; Mol Cell Biol. 1996 Feb;16(2):669-76. (PMID: 8552095) ; AIDS. 1997 Feb;11(2):139-46. (PMID: 9030359) ; Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11472-7. (PMID: 9326634) ; Cell. 2005 Jan 28;120(2):169-81. (PMID: 15680324) ; J Virol. 1993 Dec;67(12):7450-60. (PMID: 8230466) ; J Cell Physiol. 2006 May;207(2):309-14. (PMID: 16155938) ; Genes Dev. 1999 Sep 15;13(18):2339-52. (PMID: 10500090) ; Nucl Recept Signal. 2008 Feb 01;6:e004. (PMID: 18301784) Grant Information: R21 AI074410 United States AI NIAID NIH HHS; AI043894 United States AI NIAID NIH HHS; R01 AI043894 United States AI NIAID NIH HHS; AI074410 United States AI NIAID NIH HHS; R21 AI078859 United States AI NIAID NIH HHS Substance Nomenclature: 0 (Chromatin) ; 0 (Chromosomal Proteins, Non-Histone) ; 0 (Nucleosomes) ; 0 (SWI-SNF-B chromatin-remodeling complex) ; 0 (Transcription Factors) ; 0 (tat Gene Products, Human Immunodeficiency Virus) Entry Date(s): Date Created: 20100706 Date Completed: 20100914 Latest Revision: 20211020 Update Code: 20240513 PubMed Central ID: PMC2923259

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Transcription through the HIV-1 nucleosomes: effects of the PBAF complex in Tat activated transcription.