Fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces expression of the chemokine genes Cxcl4 and Cxcl7 in the perinatal mouse brain.

Mitsui, T ; Taniguchi, N ; et al.

In: Journal of applied toxicology : JAT, Jg. 31 (2011-04-01), Heft 3, S. 279-84

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Fetal exposure to dioxins affects brain development and influences behaviors in human and laboratory animals. However, the cellular target and mechanisms of the neurotoxic action of dioxins are largely unknown. To investigate the molecular basis for the neurotoxicity of dioxins, pregnant C57BL/6 mice were exposed to 5 µg kg(-1) body weight of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) by a single gavage on gestational day 12.5 (GD 12.5), and gene expression of the whole fetal brain at GD 18.5 was profiled by DNA microarray analysis. The analysis revealed that the expression of two chemokine genes, Cxcl4 and Cxcl7, was up-regulated by TCDD exposure. Real-time PCR analysis verified that they were up-regulated by TCDD in both male and female brains, while the mRNA levels of a majority of other chemokines and their receptor genes were not affected. The up-regulation was TCDD dose-dependent and peaked at GD 15.5-18.5. In situ hybridization analysis showed that the Cxcl4 mRNA expression was localized in part of the surface of cerebral cortex and that the level was increased by TCDD treatment. These results suggest that Cxcl4 and Cxcl7 play a role in the development of neurobehavioral alterations that are triggered by in utero TCDD exposure and later surface in adults.

Titel:	Fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces expression of the chemokine genes Cxcl4 and Cxcl7 in the perinatal mouse brain.
Autor/in / Beteiligte Person:	Mitsui, T ; Taniguchi, N ; Kawasaki, N ; Kagami, Y ; Arita, J
Link:	Full Text Finder (Volltext)
Zeitschrift:	Journal of applied toxicology : JAT, Jg. 31 (2011-04-01), Heft 3, S. 279-84
Veröffentlichung:	<Apr. 1992- >: Chichester : John Wiley And Sons ; <i>Original Publication</i>: [Philadelphia, Pa. : Heyden & Son, c1981-, 2011
Medientyp:	academicJournal
ISSN:	1099-1263 (electronic)
DOI:	10.1002/jat.1612
Schlagwort:	Administration, Oral Animals Autoradiography Brain drug effects Brain metabolism Brain Chemistry Chemokines, CXC metabolism Dose-Response Relationship, Drug Embryo, Mammalian drug effects Female Fetus drug effects In Situ Hybridization Male Maternal Exposure Mice Mice, Inbred C57BL Oligonucleotide Array Sequence Analysis Platelet Factor 4 metabolism Polychlorinated Dibenzodioxins administration & dosage Pregnancy RNA, Messenger analysis Up-Regulation drug effects Chemokines, CXC genetics Gene Expression drug effects Gene Expression Regulation, Developmental drug effects Platelet Factor 4 genetics Polychlorinated Dibenzodioxins toxicity Teratogens toxicity
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Appl Toxicol] 2011 Apr; Vol. 31 (3), pp. 279-84. <i>Date of Electronic Publication: </i>2011 Feb 03. MeSH Terms: Chemokines, CXC / genetics ; Gene Expression / drug effects ; Gene Expression Regulation, Developmental / drug effects ; Platelet Factor 4 / genetics ; Polychlorinated Dibenzodioxins / toxicity ; Teratogens / toxicity ; Administration, Oral ; Animals ; Autoradiography ; Brain / drug effects ; Brain / metabolism ; Brain Chemistry ; Chemokines, CXC / metabolism ; Dose-Response Relationship, Drug ; Embryo, Mammalian / drug effects ; Female ; Fetus / drug effects ; In Situ Hybridization ; Male ; Maternal Exposure ; Mice ; Mice, Inbred C57BL ; Oligonucleotide Array Sequence Analysis ; Platelet Factor 4 / metabolism ; Polychlorinated Dibenzodioxins / administration & dosage ; Pregnancy ; RNA, Messenger / analysis ; Up-Regulation / drug effects Substance Nomenclature: 0 (Chemokines, CXC) ; 0 (Cxcl7 protein, mouse) ; 0 (Polychlorinated Dibenzodioxins) ; 0 (RNA, Messenger) ; 0 (Teratogens) ; 37270-94-3 (Platelet Factor 4) Entry Date(s): Date Created: 20110422 Date Completed: 20110809 Latest Revision: 20161125 Update Code: 20231215

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