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Background/aims: It has been widely accepted that chronic inflammation plays important roles in the atherogenesis. Danshensu Bingpian Zhi (DBZ) is a novel synthetic compound derived from the traditional Chinese medicine (TCM) formula Fu Fang Dan Shen (FFDS), which is effective on atherosclerosis clinically. We hypothesized that DBZ possessed the anti-atherosclerosis potentials. Here, we examined the inhibitory effects of DBZ on LPS-induced monocyte activation and foam cell formation.

Methods: The effects of DBZ were assessed on LPS-induced inflammatory factors expression in monocyte/macrophage. Activation of NF-κB and AP-1 was analyzed by luciferase reporter assay and signaling pathway of NF-κB was investigated to elucidate mechanisms underlying DBZ mediated anti-inflammatory activity. Effects of DBZ on macrophage lipid accumulation were evaluated in native LDL and LPS co-incubated macrophages.

Results: DBZ inhibited LPS-induced inflammatory factors expression dose dependently in monocytes. DBZ inhibited NF-κB activation strongly and AP-1 slightly. DBZ suppressed the LPS-induced degradation of IκBα, thereby decreasing the translocation of p65 to nucleus. Furthermore, DBZ suppressed LPS-activated macrophages lipid accumulation, partly due to inhibiting the expression of LPS-induced aP2 and ADRP in macrophges.

Conclusion: These results demonstrate that DBZ has potentials on anti-atherosclerosis by suppressing monocyte activation and foam cell formation.

Titel:	DBZ blocks LPS-induced monocyte activation and foam cell formation via inhibiting nuclear factor-ĸB.
Autor/in / Beteiligte Person:	Xie, X ; Wang, S ; Xiao, L ; Zhang, J ; Wang, J ; Liu, J ; Shen, X ; He, D ; Zheng, X ; Zhai, Y
Zeitschrift:	Cellular physiology and biochemistry : international journal of experimental cellular, Jg. 28 (2011), Heft 4, S. 649-62
Veröffentlichung:	2019- : Düsseldorf, Germany : Cell Physiol Biochem Press GmbH & Co KG ; <i>Original Publication</i>: Basel ; New York : S. Karger, 1991-2018., 2011
Medientyp:	academicJournal
ISSN:	1421-9778 (electronic)
DOI:	10.1159/000335760
Schlagwort:	Adjuvants, Immunologic pharmacology Animals Cells, Cultured Foam Cells cytology Foam Cells drug effects Humans Interleukin-6 metabolism Macrophages drug effects Macrophages metabolism Male Medicine, Chinese Traditional Mice Mice, Inbred C57BL Monocytes metabolism NF-kappa B metabolism Nitric Oxide metabolism Transcription Factor AP-1 metabolism Transcription Factor RelA metabolism Anti-Inflammatory Agents pharmacology Camphanes pharmacology Lipopolysaccharides pharmacology Monocytes drug effects NF-kappa B antagonists & inhibitors Phenylpropionates pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Cell Physiol Biochem] 2011; Vol. 28 (4), pp. 649-62. <i>Date of Electronic Publication: </i>2011 Dec 14. MeSH Terms: Anti-Inflammatory Agents / pharmacology ; Camphanes / pharmacology ; Lipopolysaccharides / pharmacology ; Monocytes / drug effects ; NF-kappa B / antagonists & inhibitors ; Phenylpropionates / pharmacology ; Adjuvants, Immunologic / pharmacology ; Animals ; Cells, Cultured ; Foam Cells / cytology ; Foam Cells / drug effects ; Humans ; Interleukin-6 / metabolism ; Macrophages / drug effects ; Macrophages / metabolism ; Male ; Medicine, Chinese Traditional ; Mice ; Mice, Inbred C57BL ; Monocytes / metabolism ; NF-kappa B / metabolism ; Nitric Oxide / metabolism ; Transcription Factor AP-1 / metabolism ; Transcription Factor RelA / metabolism Substance Nomenclature: 0 (Adjuvants, Immunologic) ; 0 (Anti-Inflammatory Agents) ; 0 (Camphanes) ; 0 (Interleukin-6) ; 0 (Lipopolysaccharides) ; 0 (NF-kappa B) ; 0 (Phenylpropionates) ; 0 (Transcription Factor AP-1) ; 0 (Transcription Factor RelA) ; 0 (danshensu bingpian zhi) ; 31C4KY9ESH (Nitric Oxide) Entry Date(s): Date Created: 20111220 Date Completed: 20120416 Latest Revision: 20191210 Update Code: 20240513

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DBZ blocks LPS-induced monocyte activation and foam cell formation via inhibiting nuclear factor-ĸB.