Einzeltreffer — DigiBib

We studied all consensus sequences within the four least 'variable blocks' (VB) present in the DBL6ε domain of VAR2CSA, the protein involved in the adhesion of infected red blood cells by Plasmodium falciparum that causes the Pregnancy-Associated Malaria (PAM). Characterising consensus sequences with respect to recognition of antibodies and percentage of responders among pregnant women living in areas where P. falciparum is endemic allows the identification of the most antigenic sequences within each VB. When combining these consensus sequences among four serotypes from VB1 or VB5, the most often recognized ones are expected to induce pan-reactive antibodies recognizing VAR2CSA from all plasmodial strains. These sequences are of main interest in the design of an immunogenic molecule. Using a similar approach than for DBL6ε, we studied the five other DBL and the CIDRpam from VAR2CSA, and again identified VB segments with highly conserved consensus sequences. In addition, we identified consensus sequences in other var genes expressed by non-PAM parasites. This finding paves the way for vaccine design against other pathologies caused by P. falciparum.

Titel:	Plasmodium falciparum variability and immune evasion proceed from antigenicity of consensus sequences from DBL6ε; generalization to all DBL from VAR2CSA.
Autor/in / Beteiligte Person:	Deloron, P ; Milet, J ; Badaut, C
Link:	Volltext (PDF)
Zeitschrift:	PloS one, Jg. 8 (2013), Heft 1, S. e54882
Veröffentlichung:	San Francisco, CA : Public Library of Science, 2013
Medientyp:	academicJournal
ISSN:	1932-6203 (electronic)
DOI:	10.1371/journal.pone.0054882
Schlagwort:	Adult Amino Acid Motifs immunology Amino Acid Sequence Antibodies, Protozoan blood Antibodies, Protozoan immunology Antigens, Protozoan chemistry Consensus Sequence immunology Epitopes, B-Lymphocyte chemistry Epitopes, B-Lymphocyte immunology Epitopes, B-Lymphocyte metabolism Female Humans Immunoglobulin G blood Immunoglobulin G immunology Models, Molecular Molecular Sequence Data Peptides chemistry Peptides immunology Pregnancy Protein Binding Protein Conformation Sequence Alignment Young Adult Antigens, Protozoan immunology Malaria, Falciparum immunology Plasmodium falciparum immunology Protein Interaction Domains and Motifs immunology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [PLoS One] 2013; Vol. 8 (1), pp. e54882. <i>Date of Electronic Publication: </i>2013 Jan 25. MeSH Terms: Antigens, Protozoan / immunology ; Malaria, Falciparum / immunology ; Plasmodium falciparum / immunology ; Protein Interaction Domains and Motifs / immunology ; Adult ; Amino Acid Motifs / immunology ; Amino Acid Sequence ; Antibodies, Protozoan / blood ; Antibodies, Protozoan / immunology ; Antigens, Protozoan / chemistry ; Consensus Sequence / immunology ; Epitopes, B-Lymphocyte / chemistry ; Epitopes, B-Lymphocyte / immunology ; Epitopes, B-Lymphocyte / metabolism ; Female ; Humans ; Immunoglobulin G / blood ; Immunoglobulin G / immunology ; Models, Molecular ; Molecular Sequence Data ; Peptides / chemistry ; Peptides / immunology ; Pregnancy ; Protein Binding ; Protein Conformation ; Sequence Alignment ; Young Adult References: J Infect Dis. 2006 Jan 1;193(1):146-54. (PMID: 16323143) ; PLoS Med. 2005 Dec;2(12):e407. (PMID: 16259531) ; Vaccine. 2004 Dec 2;23(3):343-52. (PMID: 15530679) ; Vaccine. 2012 Feb 8;30(7):1343-8. (PMID: 22226864) ; Nature. 2000 Oct 26;407(6807):1018-22. (PMID: 11069183) ; Malar J. 2008 Sep 04;7:170. (PMID: 18771584) ; Int J Parasitol. 2009 Sep;39(11):1195-204. (PMID: 19324047) ; Mol Microbiol. 2007 Jan;63(2):335-47. (PMID: 17176260) ; J Gen Virol. 1991 Mar;72 ( Pt 3):557-65. (PMID: 1706409) ; Malar J. 2002 Apr 26;1:7. (PMID: 12057026) ; PLoS One. 2012;7(2):e31565. (PMID: 22347496) ; Infect Immun. 2008 Apr;76(4):1791-800. (PMID: 18250177) ; Am J Trop Med Hyg. 2007 Jul;77(1):22-8. (PMID: 17620626) ; PLoS Pathog. 2006 Nov;2(11):e124. (PMID: 17112315) ; J Mol Biol. 2010 Apr 2;397(3):826-34. (PMID: 20109466) ; Int J Parasitol. 2008 Aug;38(10):1099-109. (PMID: 18395207) ; Mol Biochem Parasitol. 2000 Oct;110(2):293-310. (PMID: 11071284) ; Infect Immun. 2010 May;78(5):1963-78. (PMID: 20160014) ; PLoS One. 2010 Feb 16;5(2):e9230. (PMID: 20169064) ; PLoS Comput Biol. 2010 Sep 16;6(9):. (PMID: 20862303) ; Microbes Infect. 2006 Nov-Dec;8(14-15):2863-71. (PMID: 17095277) ; J Immunol. 2001 Jan 1;166(1):481-9. (PMID: 11123327) ; Infect Immun. 2006 Aug;74(8):4875-83. (PMID: 16861676) ; PLoS One. 2012;7(1):e31011. (PMID: 22295123) ; J Infect Dis. 2005 Jul 15;192(2):331-5. (PMID: 15962229) ; J Immunol. 1992 Mar 1;148(5):1499-505. (PMID: 1371529) ; Vaccine. 1994 Aug;12(11):1012-7. (PMID: 7526570) ; Mol Biol Evol. 2010 Sep;27(9):2198-209. (PMID: 20427419) ; Mol Biochem Parasitol. 2000 Oct;110(2):391-7. (PMID: 11071291) ; Malar J. 2008 Jan 14;7:14. (PMID: 18194571) ; Infect Immun. 2006 Dec;74(12):6929-39. (PMID: 17030584) ; Mol Microbiol. 2003 Jul;49(1):179-91. (PMID: 12823820) ; PLoS One. 2010 Jun 23;5(6):e11276. (PMID: 20585655) ; PLoS Biol. 2005 Oct;3(10):e335. (PMID: 16144426) ; Gene. 2006 Aug 15;378:19-30. (PMID: 16806741) ; Mol Microbiol. 2003 Dec;50(5):1527-38. (PMID: 14651636) ; Malar J. 2012 Feb 15;11:46. (PMID: 22335967) ; J Biol Chem. 2008 Aug 8;283(32):21842-6. (PMID: 18550531) ; J Infect Dis. 2007 Jul 1;196(1):155-64. (PMID: 17538896) ; Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4884-9. (PMID: 20194779) ; J Virol. 2012 Mar;86(5):2809-16. (PMID: 22171276) ; Proc Natl Acad Sci U S A. 1988 Aug;85(15):5409-13. (PMID: 3399498) ; Ann Trop Med Parasitol. 1999 Dec;93 Suppl 1:S43-57. (PMID: 10715688) ; PLoS One. 2010 Oct 01;5(10):. (PMID: 20957045) ; Proc Natl Acad Sci U S A. 1989 May;86(10):3768-72. (PMID: 2471191) ; Mol Biochem Parasitol. 2006 Aug;148(2):169-80. (PMID: 16697476) ; Trans R Soc Trop Med Hyg. 2003 Jan-Feb;97(1):30-5. (PMID: 12886801) ; Am J Epidemiol. 1997 Nov 15;146(10):826-31. (PMID: 9384203) ; J Immunol. 2009 Sep 1;183(5):3356-63. (PMID: 19675168) ; J Infect Dis. 2011 Oct 1;204(7):1125-33. (PMID: 21881129) ; J Infect Dis. 2006 Mar 1;193(5):713-20. (PMID: 16453268) ; J Exp Med. 2004 Nov 1;200(9):1197-203. (PMID: 15520249) ; Infect Immun. 2012 Apr;80(4):1479-90. (PMID: 22331427) ; Infect Immun. 2009 Nov;77(11):4859-67. (PMID: 19703971) ; Mol Biochem Parasitol. 2007 Oct;155(2):103-12. (PMID: 17669514) ; PLoS One. 2009 Aug 19;4(8):e6667. (PMID: 19690615) Substance Nomenclature: 0 (Antibodies, Protozoan) ; 0 (Antigens, Protozoan) ; 0 (Epitopes, B-Lymphocyte) ; 0 (Immunoglobulin G) ; 0 (Peptides) ; 0 (VAR2CSA protein, Plasmodium falciparum) Entry Date(s): Date Created: 20130202 Date Completed: 20130726 Latest Revision: 20211021 Update Code: 20231215 PubMed Central ID: PMC3555990

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Plasmodium falciparum variability and immune evasion proceed from antigenicity of consensus sequences from DBL6ε; generalization to all DBL from VAR2CSA.