Critical practical aspects in the application of liquid chromatography-mass spectrometric studies for the characterization of impurities and degradation products.
In: Journal of pharmaceutical and biomedical analysis, Jg. 87 (2014), S. 191-217
academicJournal
Zugriff:
Liquid chromatography-mass spectrometry (LC-MS) is considered today as a mainstay tool for the structure characterization of minor components like impurities (IMPs) and degradation products (DPs) in drug substances and products. A multi-step systematic strategy for the purpose involves high resolution mass and multi-stage mass studies on both the drug and IMPs/DPs, followed by comparison of their fragmentation profiles. Its successful application requires consideration of many practical aspects at each step. The same are critically discussed in this review.
(Copyright © 2013 Elsevier B.V. All rights reserved.)
Titel: |
Critical practical aspects in the application of liquid chromatography-mass spectrometric studies for the characterization of impurities and degradation products.
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Autor/in / Beteiligte Person: | Narayanam, M ; Handa, T ; Sharma, P ; Jhajra, S ; Muthe, PK ; Dappili, PK ; Shah, RP ; Singh, S |
Zeitschrift: | Journal of pharmaceutical and biomedical analysis, Jg. 87 (2014), S. 191-217 |
Veröffentlichung: | <2006->: London : Elsevier Science ; <i>Original Publication</i>: Oxford ; New York : Pergamon Press, c1983-, 2014 |
Medientyp: | academicJournal |
ISSN: | 1873-264X (electronic) |
DOI: | 10.1016/j.jpba.2013.04.027 |
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