Local effect of celecoxib on peripheral nerve repair combined with silicone tubulization in rat.

Mohammadi, R ; Amini, K ; et al.

In: Chinese journal of traumatology = Zhonghua chuang shang za zhi, Jg. 16 (2013), Heft 5, S. 265-71

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Objective: To assess local effect of celecoxib on nerve regeneration in a rat sciatic nerve transection model.

Methods: Forty-five male healthy white Wistar rats were randomly divided into three experimental groups (n equal to 15 for each): sham-operation (SHAM), control (SIL) and celecoxib treated (SIL/CLX) groups. In SHAM group after anesthesia left sciatic nerve was exposed and after homeostasis muscle was sutured. In SIL group the left sciatic nerve was exposed in the same way and transected proximal to tibioperoneal bifurcation leaving a 10 mm gap. Proximal and distal stumps were each inserted into a silicone tube and filled with 10 microlitre phosphate buffered solution. In SIL/CLX group defect was bridged using a silicone tube filled with 10 microlitre celecoxib (0.1 g/L).

Results: Functional study and gastrocnemius muscle mass confirmed faster and better recovery of regenerated axons in SIL/CLX than in SIL group (P less than 0.05). Morphometric indices of regenerated fibers showed number and diameter of the myelinated fibers in SIL/CLX were significantly greater than those in control group. In immunohistochemistry, location of reactions to S-100 in SIL/CLX was clearly more positive than that in SIL group.

Conclusion: Response to local treatment of celecoxib demonstrates that it influences and improves functional recovery of peripheral nerve regeneration.

Titel:	Local effect of celecoxib on peripheral nerve repair combined with silicone tubulization in rat.
Autor/in / Beteiligte Person:	Mohammadi, R ; Amini, K ; Yousefi, A ; Abdollahi-Pirbazari, M
Link:	Full Text Finder (Volltext)
Zeitschrift:	Chinese journal of traumatology = Zhonghua chuang shang za zhi, Jg. 16 (2013), Heft 5, S. 265-71
Veröffentlichung:	Chongqing : Editorial Dept. of Chinese Journal of Traumatology, c1998-, 2013
Medientyp:	academicJournal
ISSN:	1008-1275 (print)
Schlagwort:	Animals Celecoxib Male Peripheral Nerves drug effects Random Allocation Rats Rats, Wistar Sciatic Nerve drug effects Silicones Cyclooxygenase 2 Inhibitors pharmacology Nerve Regeneration drug effects Peripheral Nerves surgery Pyrazoles pharmacokinetics Sulfonamides pharmacokinetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Chin J Traumatol] 2013; Vol. 16 (5), pp. 265-71. MeSH Terms: Cyclooxygenase 2 Inhibitors / pharmacology ; Nerve Regeneration / drug effects ; Peripheral Nerves / surgery ; Pyrazoles / pharmacokinetics ; Sulfonamides / *pharmacokinetics ; Animals ; Celecoxib ; Male ; Peripheral Nerves / drug effects ; Random Allocation ; Rats ; Rats, Wistar ; Sciatic Nerve / drug effects ; Silicones Substance Nomenclature: 0 (Cyclooxygenase 2 Inhibitors) ; 0 (Pyrazoles) ; 0 (Silicones) ; 0 (Sulfonamides) ; JCX84Q7J1L (Celecoxib) Entry Date(s): Date Created: 20131010 Date Completed: 20140731 Latest Revision: 20170208 Update Code: 20240513

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