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Aims: The diverse physiological functions of histamine are mediated through distinct histamine receptors. In this study we investigated the role of H2R and H4R in the effects of histamine on the production of reactive oxygen species by phagocytes in whole blood.

Main Methods: Changes in reactive oxygen species (ROS) production by whole blood phagocytes after treatment with histamine, H4R agonists (4-methylhistamine, VUF8430), H2R agonist (dimaprit) and their combinations with H4R antagonist (JNJ10191584) and H2R antagonist (ranitidine) were determined using the chemiluminescence (CL) assay. To exclude the direct scavenging effects of the studied compounds on the CL response, the antioxidant properties of all compounds were measured using several methods (TRAP, ORAC, and luminol-HRP-H2O2 based CL).

Key Findings: Histamine, 4-methylhistamine, VUF8430 and dimaprit inhibited the spontaneous and OZP-activated whole blood CL in a dose-dependent manner. On the other hand, only VUF8430 was able to inhibit PMA-activated whole blood CL. Ranitidine, but not JNJ10191584, completely reduced the effects of histamine, 4-methylhistamine and dimaprit. The direct scavenging ability of tested compounds was negligible.

Significance: Our results demonstrate that the inhibitory effects of histamine on ROS production in whole blood phagocytes were caused by H2R. Our results also suggest that H4R agonists in concentrations higher than 10(-6)M may also influence ROS production via binding to H2R.

Titel:	Role of histamine receptors in the effects of histamine on the production of reactive oxygen species by whole blood phagocytes.
Autor/in / Beteiligte Person:	Vasicek, O ; Lojek, A ; Jancinova, V ; Nosal, R ; Ciz, M
Zeitschrift:	Life sciences, Jg. 100 (2014-03-28), Heft 1, S. 67-72
Veröffentlichung:	<2008->: Amsterdam : Elsevier ; <i>Original Publication</i>: Oxford; Elmsford, N. Y. [etc.] Pergamon Press., 2014
Medientyp:	academicJournal
ISSN:	1879-0631 (electronic)
DOI:	10.1016/j.lfs.2014.01.082
Schlagwort:	Benzimidazoles pharmacology Dimaprit pharmacology Guanidines pharmacology Histamine Agonists pharmacology Humans Male Methylhistamines pharmacology Phagocytes drug effects Receptors, G-Protein-Coupled agonists Receptors, Histamine H4 Thiourea analogs & derivatives Thiourea pharmacology Histamine physiology Phagocytes metabolism Reactive Oxygen Species blood Receptors, G-Protein-Coupled metabolism Receptors, Histamine metabolism Receptors, Histamine H2 metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Life Sci] 2014 Mar 28; Vol. 100 (1), pp. 67-72. <i>Date of Electronic Publication: </i>2014 Feb 12. MeSH Terms: Histamine / physiology ; Phagocytes / metabolism ; Reactive Oxygen Species / blood ; Receptors, G-Protein-Coupled / metabolism ; Receptors, Histamine / metabolism ; Receptors, Histamine H2 / metabolism ; Benzimidazoles / pharmacology ; Dimaprit / pharmacology ; Guanidines / pharmacology ; Histamine Agonists / pharmacology ; Humans ; Male ; Methylhistamines / pharmacology ; Phagocytes / drug effects ; Receptors, G-Protein-Coupled / agonists ; Receptors, Histamine H4 ; Thiourea / analogs & derivatives ; Thiourea / pharmacology Contributed Indexing: Keywords: H(2)R; H(4)R; Histamine; Histamine receptors; Phagocytes; Reactive oxygen species Substance Nomenclature: 0 (Benzimidazoles) ; 0 (Guanidines) ; 0 (HRH4 protein, human) ; 0 (Histamine Agonists) ; 0 (JNJ 10191584) ; 0 (Methylhistamines) ; 0 (Reactive Oxygen Species) ; 0 (Receptors, G-Protein-Coupled) ; 0 (Receptors, Histamine) ; 0 (Receptors, Histamine H2) ; 0 (Receptors, Histamine H4) ; 0 (S-(2-guanidylethyl)isothiourea) ; 54ST71P9EE (4-methylhistamine) ; 820484N8I3 (Histamine) ; GYV9AM2QAG (Thiourea) ; ZZQ699148P (Dimaprit) Entry Date(s): Date Created: 20140218 Date Completed: 20140513 Latest Revision: 20171116 Update Code: 20240513

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Role of histamine receptors in the effects of histamine on the production of reactive oxygen species by whole blood phagocytes.