A study of Semen Strychni-induced renal injury and herb-herb interaction of Radix Glycyrrhizae extract and/or Rhizoma Ligustici extract on the comparative toxicokinetics of strychnine and brucine in rats.

Gu, L ; Wang, X ; et al.

In: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Jg. 68 (2014-06-01), S. 226-33

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Recently, the renal injury caused by Semen strychni and its major toxic constituents, strychnine and brucine, was reported in many clinical cases. Hence, this study was conducted to investigate the renal injury induced by Semen Strychni and the protective effects of Radix Glycyrrhizae and Rhizoma Ligustici. The protective mechanisms were related to the comparative toxicokinetics of strychnine and brucine. Serum and urine uric acid and creatinine were used as renal function markers to evaluate the condition of kidney, and renal injury was directly reflected by histopathological changes. Compared with rats in blank group and protective herb groups, rats in Semen Strychni high-dose group showed significant differences in the results of renal function markers, and various glomerular and tubular degenerations were found in the histopathological study. The decreased AUC (only strychnine) and Cmax, the increased Tmax by Radix Glycyrrhizae and the decreased T1/2 by Radix Glycyrrhizae and Rhizoma Ligustici were found in model groups. Results indicated that high dose of Semen Strychni might induce renal injury. Radix Glycyrrhizae and Rhizoma Ligustici might work together and have effects on the elimination of strychnine and brucine. The protective effects of Radix Glycyrrhizae might also be explained by the slow absorption of the alkaloids.

Titel:	A study of Semen Strychni-induced renal injury and herb-herb interaction of Radix Glycyrrhizae extract and/or Rhizoma Ligustici extract on the comparative toxicokinetics of strychnine and brucine in rats.
Autor/in / Beteiligte Person:	Gu, L ; Wang, X ; Liu, Z ; Ju, P ; Zhang, L ; Zhang, Y ; Ma, B ; Bi, K ; Chen, X
Zeitschrift:	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Jg. 68 (2014-06-01), S. 226-33
Veröffentlichung:	Exeter : Elsevier Science Ltd ; <i>Original Publication</i>: Oxford ; New York : Pergamon Press, c1982-, 2014
Medientyp:	academicJournal
ISSN:	1873-6351 (electronic)
DOI:	10.1016/j.fct.2014.03.028
Schlagwort:	Animals Biomarkers urine Creatinine urine Dose-Response Relationship, Drug Kidney drug effects Kidney Diseases chemically induced Kidney Diseases urine Male Rats Rats, Sprague-Dawley Strychnine adverse effects Strychnos adverse effects Toxicokinetics Uric Acid urine Drugs, Chinese Herbal pharmacology Glycyrrhiza chemistry Herb-Drug Interactions Plant Extracts pharmacology Rhizome chemistry Strychnine analogs & derivatives
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Food Chem Toxicol] 2014 Jun; Vol. 68, pp. 226-33. <i>Date of Electronic Publication: </i>2014 Apr 01. MeSH Terms: Herb-Drug Interactions* ; Drugs, Chinese Herbal / pharmacology ; Glycyrrhiza / chemistry ; Plant Extracts / pharmacology ; Rhizome / chemistry ; Strychnine / *analogs & derivatives ; Animals ; Biomarkers / urine ; Creatinine / urine ; Dose-Response Relationship, Drug ; Kidney / drug effects ; Kidney Diseases / chemically induced ; Kidney Diseases / urine ; Male ; Rats ; Rats, Sprague-Dawley ; Strychnine / adverse effects ; Strychnos / adverse effects ; Toxicokinetics ; Uric Acid / urine Contributed Indexing: Keywords: Brucine; Herb–herb interaction; Kidney injury; Semen Strychni; Strychnine; Toxicokinetic Substance Nomenclature: 0 (Biomarkers) ; 0 (Drugs, Chinese Herbal) ; 0 (Plant Extracts) ; 268B43MJ25 (Uric Acid) ; 6NG17YCK6H (brucine) ; AYI8EX34EU (Creatinine) ; H9Y79VD43J (Strychnine) Entry Date(s): Date Created: 20140408 Date Completed: 20150105 Latest Revision: 20151119 Update Code: 20231215

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