Allogeneic DCG promote lung NK cell activation and antitumor effect after invariant NKT cell activation.

Hasegawa, H ; Yamashita, K ; et al.

In: Anticancer research, Jg. 34 (2014-07-01), Heft 7, S. 3411-7

Online academicJournal

Zugriff:

Full Text Finder (Volltext)

Aim: We aimed to investigate whether allogeneic dendritic cells pulsed with alpha-galactosylceramide (DCG) treatment induces activation of Natural Killer T (NKT) cells.

Materials and Methods: C57BL/6 and BALB/c mice were injected with syngeneic and allogeneic DCG. We then examined NK and NKT cell activity in the lung and spleen and antitumor effect in various lung tumor metastatic models.

Results: While splenic NKT activity was suppressed after allogeneic DCG treatment, allogeneic DCG treatment induced similar antitumor effect as well as lung NKT and NK cell activity compared to syngeneic DCG treatment. Furthermore, allogeneic DCG treatment prolonged survival in B16F10, LLC, Pan02, MethA, and CT26 tumor models in two strains of mice.

Conclusion: This allogeneic DCG treatment could be substituted for syngeneic DCG treatment. The results obtained in the present study suggest that allogeneic DCG treatment may provide a new approach in cancer immunotherapy with NKT cells.

Titel:	Allogeneic DCG promote lung NK cell activation and antitumor effect after invariant NKT cell activation.
Autor/in / Beteiligte Person:	Hasegawa, H ; Yamashita, K ; Otubo, D ; Fujii, S ; Kamigaki, T ; Kuroda, D ; Kakeji, Y
Link:	Full Text Finder (Volltext)
Zeitschrift:	Anticancer research, Jg. 34 (2014-07-01), Heft 7, S. 3411-7
Veröffentlichung:	Attiki, Greece : International Institute of Anticancer Research ; <i>Original Publication</i>: Athens, Greece : Potamitis Press, 2014
Medientyp:	academicJournal
ISSN:	1791-7530 (electronic)
Schlagwort:	Animals Colonic Neoplasms immunology Female Galactosylceramides immunology Interferon-gamma biosynthesis Interferon-gamma immunology Lung Neoplasms drug therapy Lung Neoplasms immunology Lung Neoplasms secondary Lymphocyte Activation drug effects Mammary Neoplasms, Experimental immunology Melanoma, Experimental immunology Melanoma, Experimental secondary Mice Mice, Inbred BALB C Mice, Inbred C57BL Colonic Neoplasms drug therapy Galactosylceramides pharmacology Mammary Neoplasms, Experimental drug therapy Melanoma, Experimental drug therapy Natural Killer T-Cells drug effects Natural Killer T-Cells immunology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Anticancer Res] 2014 Jul; Vol. 34 (7), pp. 3411-7. MeSH Terms: Colonic Neoplasms / drug therapy ; Galactosylceramides / pharmacology ; Mammary Neoplasms, Experimental / drug therapy ; Melanoma, Experimental / drug therapy ; Natural Killer T-Cells / drug effects ; Natural Killer T-Cells / immunology ; Animals ; Colonic Neoplasms / immunology ; Female ; Galactosylceramides / immunology ; Interferon-gamma / biosynthesis ; Interferon-gamma / immunology ; Lung Neoplasms / drug therapy ; Lung Neoplasms / immunology ; Lung Neoplasms / secondary ; Lymphocyte Activation / drug effects ; Mammary Neoplasms, Experimental / immunology ; Melanoma, Experimental / immunology ; Melanoma, Experimental / secondary ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL Contributed Indexing: Keywords: NK cells; NKT cells; allogeneic cells; dendritic cells; tumor immunity Substance Nomenclature: 0 (Galactosylceramides) ; 0 (alpha-galactosylceramide) ; 82115-62-6 (Interferon-gamma) Entry Date(s): Date Created: 20140702 Date Completed: 20140821 Latest Revision: 20140701 Update Code: 20240513

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.