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Objective: This study aims to explore the protective effect mechanism of 2-deoxy-D-glucose on nephrotoxicity of cyclosporin A in vivo.

Method: Renal toxicity of SD rats model induced by CsA was established. Serum creatinine, blood urea nitrogen, urine NAG, GSH and MDA were determined and the histopathological changes of rat renal cortex were observed to explore the protective effects of 2-DG on CsA-induced nephrotoxicity.

Results: Serum creatinine, BUN and urinary NAG of rats were significantly changed in experimental groups. Pathological results showed that there was obvious renal tubular injury in model group, however, the renal injury was significantly reduced in pre-treated with 2-DG.

Conclusions: 2-DG had obvious protective effect on nephrotoxicity especially with high dose. This protective effect could be related to the reduction of ROS induced by CsA. However, 2-DG had no effect on the expression of RIP3.

Titel:	Protective effects of 2-deoxy-D-glucose on nephrotoxicity induced by cyclosporine A in rats.
Autor/in / Beteiligte Person:	Ouyang, Z ; Cao, W ; Zhu, S ; Liu, X ; Zhong, Z ; Lai, X ; Deng, H ; Jiang, S ; Wang, Y
Zeitschrift:	International journal of clinical and experimental pathology, Jg. 7 (2014-07-15), Heft 8, S. 4587-95
Veröffentlichung:	Madison, WI : e-Century Pub. Corp., [2008]-, 2014
Medientyp:	academicJournal
ISSN:	1936-2625 (electronic)
Schlagwort:	Animals Blotting, Western Immunohistochemistry Kidney pathology Kidney Diseases chemically induced Kidney Diseases pathology Rats Rats, Sprague-Dawley Antimetabolites pharmacology Cyclosporine toxicity Deoxyglucose pharmacology Immunosuppressive Agents toxicity Kidney drug effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Int J Clin Exp Pathol] 2014 Jul 15; Vol. 7 (8), pp. 4587-95. <i>Date of Electronic Publication: </i>2014 Jul 15 (<i>Print Publication: </i>2014). MeSH Terms: Antimetabolites / pharmacology ; Cyclosporine / toxicity ; Deoxyglucose / pharmacology ; Immunosuppressive Agents / toxicity ; Kidney / *drug effects ; Animals ; Blotting, Western ; Immunohistochemistry ; Kidney / pathology ; Kidney Diseases / chemically induced ; Kidney Diseases / pathology ; Rats ; Rats, Sprague-Dawley References: Nat Biotechnol. 2010 May;28(5):478-85. (PMID: 20458318) ; Immunol Invest. 2007;36(1):105-14. (PMID: 17190653) ; Asian J Neurosurg. 2013 Jan;8(1):9-14. (PMID: 23741257) ; N Engl J Med. 2000 Mar 2;342(9):605-12. (PMID: 10699159) ; J Neurosci Res. 1999 Jul 15;57(2):195-206. (PMID: 10398297) ; Basic Clin Pharmacol Toxicol. 2008 Aug;103(2):186-91. (PMID: 18816304) ; Am J Physiol. 1998 Oct;275(4):F595-604. (PMID: 9755131) ; Gen Physiol Biophys. 2010 Mar;29(1):85-94. (PMID: 20371885) ; Nutr Metab (Lond). 2008 Nov 25;5:33. (PMID: 19032781) ; Kidney Int. 2000 Apr;57(4):1549-59. (PMID: 10760090) ; Pharmazie. 2012 Aug;67(8):725-32. (PMID: 22957440) ; Drugs Exp Clin Res. 1995;21(6):221-8. (PMID: 8907697) ; Clin Nephrol. 1986;25 Suppl 1:S100-4. (PMID: 2871955) ; J Appl Toxicol. 2008 Jan;28(1):15-20. (PMID: 17461432) ; Kidney Int. 1998 Dec;54(6):1955-66. (PMID: 9853260) ; Pharmacol Res. 2002 Jun;45(6):441-6. (PMID: 12162943) ; Hypertension. 1998 Nov;32(5):849-55. (PMID: 9822443) ; J Am Soc Nephrol. 1993 Aug;4(2):214-21. (PMID: 8400085) ; J Ren Nutr. 2003 Apr;13(2):84-92. (PMID: 12671830) ; J Appl Toxicol. 2009 Aug;29(6):522-30. (PMID: 19391111) ; Curr Opin Immunol. 1992 Oct;4(5):553-60. (PMID: 1418718) ; Drug Chem Toxicol. 2001 Nov;24(4):429-37. (PMID: 11665651) ; Can Med Assoc J. 1982 May 1;126(9):1041-6. (PMID: 7074504) ; Ren Fail. 2008;30(4):453-9. (PMID: 18569921) ; Food Chem Toxicol. 2008 May;46(5):1844-50. (PMID: 18308444) ; Biol Pharm Bull. 2007 Dec;30(12):2371-5. (PMID: 18057728) ; J Cancer Res Ther. 2009 Sep;5 Suppl 1:S48-52. (PMID: 20009295) ; Clin Investig. 1993 Oct;71(10):858-60. (PMID: 8305849) Contributed Indexing: Keywords: 2-deoxy-D-glucose; Cyclosporin A; GSH; MDA; RIP3; SD rats model Substance Nomenclature: 0 (Antimetabolites) ; 0 (Immunosuppressive Agents) ; 83HN0GTJ6D (Cyclosporine) ; 9G2MP84A8W (Deoxyglucose) Entry Date(s): Date Created: 20140909 Date Completed: 20150609 Latest Revision: 20211021 Update Code: 20240513 PubMed Central ID: PMC4152021

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Protective effects of 2-deoxy-D-glucose on nephrotoxicity induced by cyclosporine A in rats.