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We retrospectively analyzed the impact of HLA-DPB1 mismatches in a large cohort of 1342 French patients who underwent 10/10 HLA-matched unrelated HSCT. A significant impact of HLA-DPB1 allelic mismatches (2 vs 0) was observed in severe acute GVHD (aGVHDIII-IV) (risk ratio (RR)=1.73, confidence interval (CI) 95% 1.09-2.73, P=0.019) without impact on OS, TRM, relapse and chronic GVHD (cGVHD). According to the T-cell epitope 3 (TCE3)/TCE4 HLA-DPB1 disparity algorithm, 37.6% and 58.4% pairs had nonpermissive HLA-DPB1, respectively. TCE3 and TCE4 disparities had no statistical impact on OS, TRM, relapse, aGVHD and cGVHD. When TCE3/TCE4 disparities were analyzed in the graft-vs-host or host-vs-graft (HVG) direction, only a significant impact of TCE4 nonpermissive disparities in the HVG direction was observed on relapse (RR=1.34, CI 95% 1.00-1.80, P=0.048). In conclusion, this French retrospective study shows an adverse prognosis of HLA-DPB1 mismatches (2 vs 0) on severe aGVHD and of nonpermissive TCE4 HVG disparities on relapse after HLA-matched 10/10 unrelated HSCT.

Titel:	Is there any impact of HLA-DPB1 disparity in 10/10 HLA-matched unrelated hematopoietic SCT? Results of a French multicentric retrospective study.
Autor/in / Beteiligte Person:	Gagne, K ; Loiseau, P ; Dubois, V ; Dufossé, F ; Perrier, P ; Dormoy, A ; Jollet, I ; Renac, V ; Masson, D ; Picard, C ; Lafarge, X ; Hanau, D ; Quainon, F ; Delbos, F ; Coeffic, B ; Absi, L ; Eliaou, JF ; Moalic, V ; Fort, M ; de Matteis M ; Theodorou, I ; Hau, F ; Batho, A ; Pedron, B ; Caillat-Zucman, S ; Marry, E ; Raus, N ; Yakoub-Agha, I ; Cesbron, A
Link:	Volltext (PDF) View record at Springer (Volltext)
Zeitschrift:	Bone marrow transplantation, Jg. 50 (2015-02-01), Heft 2, S. 232-6
Veröffentlichung:	<2003->: London : Nature Publishing Group ; <i>Original Publication</i>: Basingstoke, Hampshire : Scientific & Medical Division, Macmillan Press, c1986-, 2015
Medientyp:	academicJournal
ISSN:	1476-5365 (electronic)
DOI:	10.1038/bmt.2014.253
Schlagwort:	Adolescent Adult Aged Allografts Child Child, Preschool Female France Graft vs Host Disease mortality Graft vs Host Disease prevention & control Hematologic Neoplasms mortality Host vs Graft Reaction Humans Male Middle Aged Algorithms HLA-DP beta-Chains Hematologic Neoplasms therapy Hematopoietic Stem Cell Transplantation Unrelated Donors
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Language: English [Bone Marrow Transplant] 2015 Feb; Vol. 50 (2), pp. 232-6. <i>Date of Electronic Publication: </i>2014 Nov 03. MeSH Terms: Algorithms* ; HLA-DP beta-Chains* ; Hematopoietic Stem Cell Transplantation* ; Unrelated Donors* ; Hematologic Neoplasms / *therapy ; Adolescent ; Adult ; Aged ; Allografts ; Child ; Child, Preschool ; Female ; France ; Graft vs Host Disease / mortality ; Graft vs Host Disease / prevention & control ; Hematologic Neoplasms / mortality ; Host vs Graft Reaction ; Humans ; Male ; Middle Aged References: Br J Haematol. 2010 Aug;150(3):251-8. (PMID: 20560963) ; Blood. 2007 Dec 15;110(13):4560-6. (PMID: 17726164) ; Leukemia. 2010 Jan;24(1):58-65. (PMID: 19924143) ; Blood. 2010 Sep 16;116(11):1991-2. (PMID: 20847212) ; Br J Haematol. 2008 Jul;142(3):436-43. (PMID: 18544086) ; Bone Marrow Transplant. 2014 May;49(5):657-63. (PMID: 24535129) ; Blood. 2009 Aug 13;114(7):1437-44. (PMID: 19515726) ; Biol Blood Marrow Transplant. 2013 Jan;19(1):40-8. (PMID: 22871556) ; Blood. 2009 Mar 19;113(12):2851-8. (PMID: 18997170) ; Hum Immunol. 2012 Jul;73(7):711-4. (PMID: 22504408) ; Tissue Antigens. 2003 Sep;62(3):243-50. (PMID: 12956878) ; Br J Haematol. 2001 Mar;112(4):988-94. (PMID: 11298597) ; Biol Blood Marrow Transplant. 2007 Aug;13(8):965-74. (PMID: 17640601) ; Curr Opin Immunol. 2008 Oct;20(5):588-93. (PMID: 18674615) ; Bone Marrow Transplant. 2013 Nov;48(12):1510-2. (PMID: 23811815) ; Tissue Antigens. 2007 Apr;69 Suppl 1:36-41. (PMID: 17445160) ; Lancet Oncol. 2012 Apr;13(4):366-74. (PMID: 22340965) ; Lancet Oncol. 2010 Jul;11(7):653-60. (PMID: 20558104) ; Blood. 2014 Oct 16;124(16):2596-606. (PMID: 25161269) ; Hum Immunol. 1999 Jun;60(6):532-8. (PMID: 10408803) ; Bone Marrow Transplant. 2002 Oct;30(8):497-502. (PMID: 12379888) ; J Clin Invest. 1996 Jul 1;98(1):100-7. (PMID: 8690780) ; Blood. 2004 Feb 15;103(4):1417-24. (PMID: 14576061) ; Biol Blood Marrow Transplant. 2012 Apr;18(4):608-16. (PMID: 21963878) Substance Nomenclature: 0 (HLA-DP beta-Chains) ; 0 (HLA-DPB1 antigen) Entry Date(s): Date Created: 20141104 Date Completed: 20150928 Latest Revision: 20211021 Update Code: 20240513

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Is there any impact of HLA-DPB1 disparity in 10/10 HLA-matched unrelated hematopoietic SCT? Results of a French multicentric retrospective study.