MicroRNA-520g induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by targeting SMAD7.

Kan, H ; Guo, W ; et al.

In: FEBS letters, Jg. 589 (2015-01-02), Heft 1, S. 102-9

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Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Aberrant expression of miRNAs contributes to HCC development. Here, we observed elevated miR-520g expression in tumor samples from HCC patients with relapse and metastasis, and this high miR-520g expression was correlated with poor survival. Through gain- and loss-of-function studies, miR-520g was demonstrated to facilitate HCC cell migration, invasion and epithelial-mesenchymal transition (EMT). SMAD7 was identified as a direct target of miR-520g. Accordingly, we conclude that high miR-520g expression promotes HCC cell mobility and EMT by targeting SMAD7, and this is correlated with reduced survival in HCC patients.

Titel:	MicroRNA-520g induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by targeting SMAD7.
Autor/in / Beteiligte Person:	Kan, H ; Guo, W ; Huang, Y ; Liu, D
Link:	Full Text Finder (Volltext)
Zeitschrift:	FEBS letters, Jg. 589 (2015-01-02), Heft 1, S. 102-9
Veröffentlichung:	Jan. 2016- : West Sussex : John Wiley & Sons Ltd. ; <i>Original Publication</i>: Amsterdam, North-Holland on behalf of the Federation of European Biochemical Societies., 2015
Medientyp:	academicJournal
ISSN:	1873-3468 (electronic)
DOI:	10.1016/j.febslet.2014.11.031
Schlagwort:	Adult Aged Carcinoma, Hepatocellular genetics Carcinoma, Hepatocellular mortality Carcinoma, Hepatocellular pathology Disease-Free Survival Female Hep G2 Cells Humans Liver Neoplasms genetics Liver Neoplasms mortality Liver Neoplasms pathology Male MicroRNAs genetics Middle Aged Neoplasm Metastasis Neoplasm Proteins genetics RNA, Neoplasm genetics Smad7 Protein genetics Survival Rate Carcinoma, Hepatocellular metabolism Epithelial-Mesenchymal Transition Liver Neoplasms metabolism MicroRNAs metabolism Neoplasm Proteins metabolism RNA, Neoplasm metabolism Smad7 Protein metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication Language: English [FEBS Lett] 2015 Jan 02; Vol. 589 (1), pp. 102-9. <i>Date of Electronic Publication: </i>2014 Nov 29. MeSH Terms: Epithelial-Mesenchymal Transition* ; Carcinoma, Hepatocellular / metabolism ; Liver Neoplasms / metabolism ; MicroRNAs / metabolism ; Neoplasm Proteins / metabolism ; RNA, Neoplasm / metabolism ; Smad7 Protein / metabolism ; Adult ; Aged ; Carcinoma, Hepatocellular / genetics ; Carcinoma, Hepatocellular / mortality ; Carcinoma, Hepatocellular / pathology ; Disease-Free Survival ; Female ; Hep G2 Cells ; Humans ; Liver Neoplasms / genetics ; Liver Neoplasms / mortality ; Liver Neoplasms / pathology ; Male ; MicroRNAs / genetics ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Proteins / genetics ; RNA, Neoplasm / genetics ; Smad7 Protein / genetics ; Survival Rate Comments: Retraction in: FEBS Lett. 2022 Feb;596(4):526. (PMID: 35040125) ; Retraction in: FEBS Open Bio. 2022 Feb;12(2):549. (PMID: 35040269) Contributed Indexing: Keywords: Cancer metastasis; Epithelial–mesenchymal transition; Hepatocellular carcinoma; MicroRNA-520g; SMAD family member 7 Substance Nomenclature: 0 (MIRN520 microRNA, human) ; 0 (MicroRNAs) ; 0 (Neoplasm Proteins) ; 0 (RNA, Neoplasm) ; 0 (SMAD7 protein, human) ; 0 (Smad7 Protein) Entry Date(s): Date Created: 20141202 Date Completed: 20150217 Latest Revision: 20220311 Update Code: 20231215

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