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This review covers the spatial and temporal rules governing induction of hippocampal long-term potentiation (LTP) by theta-burst stimulation. Induction of LTP in field CA1 by high frequency stimulation bursts that resemble the burst discharges (complex-spikes) of hippocampal pyramidal neurons involves a multiple-step mechanism. A single burst is insufficient for LTP induction because it evokes both excitatory and inhibitory currents that partially cancel and limit postsynaptic depolarization. Bursts repeated at the frequency (~5 Hz) of the endogenous theta rhythm induce maximal LTP, primarily because this frequency disables feed-forward inhibition and allows sufficient postsynaptic depolarization to activate voltage-sensitive NMDA receptors. The disinhibitory process, referred to as "priming", involves presynaptic GABA autoreceptors that inhibit GABA release. Activation of NMDA receptors allows a calcium flux into dendritic spines that serves as the proximal trigger for LTP. We include new data showing that theta-burst stimulation is more efficient than other forms of stimulation for LTP induction. In addition, we demonstrate that associative interactions between synapses activated during theta-bursts are limited to major dendritic domains since such interactions occur within apical or basal dendritic trees but not between them. We review evidence that recordings of electrophysiological responses during theta burst stimulation can help to determine if experimental manipulations that affect LTP do so by affecting events antecedent to the induction process, such as NMDA receptor activation, or downstream signaling cascades that result from postsynaptic calcium fluxes. Finally, we argue that theta-burst LTP represents a minimal model for stable, non-decremental LTP that is more sensitive to a variety of experimental manipulations than is LTP induced by other stimulation paradigms. This article is part of a Special Issue entitled SI: Brain and Memory.

Titel:	Theta-burst LTP.
Autor/in / Beteiligte Person:	Larson, J ; Munkácsy, E
Zeitschrift:	Brain research, Jg. 1621 (2015-09-24), S. 38-50
Veröffentlichung:	Amsterdam Elsevier/North-Holland Biomedical Press., 2015
Medientyp:	academicJournal
ISSN:	1872-6240 (electronic)
DOI:	10.1016/j.brainres.2014.10.034
Schlagwort:	Animals Humans Membrane Potentials Pyramidal Cells physiology Synapses physiology Electric Stimulation methods Hippocampus physiology Long-Term Potentiation
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(PMID: 7917027) Grant Information: R01 DC005793 United States DC NIDCD NIH HHS; T32 AG021890 United States AG NIA NIH HHS; I01 BX002211 United States BX BLRD VA; T32AG021890 United States AG NIA NIH HHS; DC005793 United States DC NIDCD NIH HHS; RF1 AG068283 United States AG NIA NIH HHS Contributed Indexing: Keywords: AMPA; CA1; GABA; Hippocampus; LTP; Long-term potentiation; NMDA; Theta burst stimulation Entry Date(s): Date Created: 20141203 Date Completed: 20160523 Latest Revision: 20230816 Update Code: 20240513 PubMed Central ID: PMC4411212

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Theta-burst LTP.