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The Hippo tumor-suppressor pathway is regulated by several multicomponent complexes of cell polarity and cell-to-cell junctions. Hippo kinases inhibit the transcription coactivator YAP. In contrast to the orthologous pathway in Drosophila, in which the single transmembrane receptor Fat and its ligand Dachsous are "dedicated" to trigger the pathway, the mammalian Hippo-YAP pathway was without such a dedicated receptor. In this issue of Science Signaling, a study by Haskins et al. has brought an end to this scenario of an "orphaned" pathway by identifying neuregulin 1 and its cognate receptor ERBB4 [epidermal growth factor receptor (EGFR) family member v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4] as a major receptor complex that activates YAP activity. Moreover, the identification of ERBB4 as a dominant receptor of YAP signaling brings into focus the signaling interface between the EGFR signaling axis and the Hippo-YAP network, with numerous implications for basic and applied cancer research.

Titel:	Neuregulin 1-activated ERBB4 as a "dedicated" receptor for the Hippo-YAP pathway.
Autor/in / Beteiligte Person:	Sudol, M
Zeitschrift:	Science signaling, Jg. 7 (2014-12-09), Heft 355, S. pe29
Veröffentlichung:	Washington, D.C. : American Association for the Advancement of Science, 2014
Medientyp:	academicJournal
ISSN:	1937-9145 (electronic)
DOI:	10.1126/scisignal.aaa2710
Schlagwort:	Animals Cell Cycle Proteins Hippo Signaling Pathway Humans Neoplasms genetics Neoplasms pathology Neuregulin-1 genetics Nuclear Proteins genetics Protein Serine-Threonine Kinases genetics Receptor, ErbB-4 genetics Transcription Factors genetics Neoplasms metabolism Neuregulin-1 metabolism Nuclear Proteins metabolism Protein Serine-Threonine Kinases metabolism Receptor, ErbB-4 metabolism Signal Transduction Transcription Factors metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review Language: English [Sci Signal] 2014 Dec 09; Vol. 7 (355), pp. pe29. <i>Date of Electronic Publication: </i>2014 Dec 09. MeSH Terms: Signal Transduction* ; Neoplasms / metabolism ; Neuregulin-1 / metabolism ; Nuclear Proteins / metabolism ; Protein Serine-Threonine Kinases / metabolism ; Receptor, ErbB-4 / metabolism ; Transcription Factors / metabolism ; Animals ; Cell Cycle Proteins ; Hippo Signaling Pathway ; Humans ; Neoplasms / genetics ; Neoplasms / pathology ; Neuregulin-1 / genetics ; Nuclear Proteins / genetics ; Protein Serine-Threonine Kinases / genetics ; Receptor, ErbB-4 / genetics ; Transcription Factors / genetics Substance Nomenclature: 0 (Cell Cycle Proteins) ; 0 (NRG1 protein, human) ; 0 (Neuregulin-1) ; 0 (Nuclear Proteins) ; 0 (Transcription Factors) ; 0 (YY1AP1 protein, human) ; EC 2.7.10.1 (ERBB4 protein, human) ; EC 2.7.10.1 (Receptor, ErbB-4) ; EC 2.7.11.1 (Protein Serine-Threonine Kinases) Entry Date(s): Date Created: 20141211 Date Completed: 20150812 Latest Revision: 20211203 Update Code: 20240513

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Neuregulin 1-activated ERBB4 as a "dedicated" receptor for the Hippo-YAP pathway.