N-terminal pro-brain natriuretic peptide in acute Kawasaki disease correlates with coronary artery involvement.
In: Cardiology in the young, Jg. 25 (2015-10-01), Heft 7, S. 1311-8
Online
academicJournal
Zugriff:
Background: We have lately documented the importance of N-terminal pro-brain natriuretic peptide in aiding the diagnosis of Kawasaki disease.
Objectives: We sought to investigate the potential value of N-terminal pro-brain natriuretic peptide pertaining to the prediction of coronary artery dilatation (Z-score>2.5) and/or of resistance to intravenous immunoglobulin therapy. We hypothesised that increased serum N-terminal pro-brain natriuretic peptide level correlates with increased coronary artery dilatation and/or resistance to intravenous immunoglobulin.
Methods: We carried out a prospective study involving newly diagnosed patients treated with 2 g/kg intravenous immunoglobulin within 5-10 days of onset of fever. Echocardiography was performed in all patients at onset, then weekly for 3 weeks, then at month 2, and month 3. Coronary arteries were measured at each visit, and coronary artery Z-score was calculated. All the patients had N-terminal pro-brain natriuretic peptide serum level measured at onset, and the Z-score calculated.
Results: There were 109 patients enrolled at 6.58±2.82 days of fever, age 3.79±2.92 years. High N-terminal pro-brain natriuretic peptide level was associated with coronary artery dilatation at onset in 22.2 versus 5.6% for normal N-terminal pro-brain natriuretic peptide levels (odds ratio 4.8 [95% confidence interval 1.05-22.4]; p=0.031). This was predictive of cumulative coronary artery dilatation for the first 3 months (p=0.04-0.02), but not during convalescence at 2-3 months (odds ratio 1.28 [95% confidence interval 0.23-7.3]; p=non-significant). Elevated N-terminal pro-brain natriuretic peptide levels did not predict intravenous immunoglobulin resistance, 15.3 versus 13.5% (p=1).
Conclusion: Elevated N-terminal pro-brain natriuretic peptide level correlates with acute coronary artery dilatation in treated Kawasaki disease, but not with intravenous immunoglobulin resistance.
Titel: |
N-terminal pro-brain natriuretic peptide in acute Kawasaki disease correlates with coronary artery involvement.
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Autor/in / Beteiligte Person: | Adjagba, PM ; Desjardins, L ; Fournier, A ; Spigelblatt, L ; Montigny, M ; Dahdah, N |
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Zeitschrift: | Cardiology in the young, Jg. 25 (2015-10-01), Heft 7, S. 1311-8 |
Veröffentlichung: | <2005->: Cambridge : Cambridge University Press ; <i>Original Publication</i>: Chapel Hill, NC : World Publishers, c1991-, 2015 |
Medientyp: | academicJournal |
ISSN: | 1467-1107 (electronic) |
DOI: | 10.1017/S1047951114002431 |
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