Ongoing cumulative effects of single TMS pulses on corticospinal excitability: An intra- and inter-block investigation.
In: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, Jg. 127 (2016), Heft 1, S. 621-628
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Zugriff:
Objective: To evaluate the effects of several single TMS pulses, delivered at two different inter-trial intervals (ITIs), on corticospinal excitability.
Methods: Twelve healthy volunteers participated in two experimental sessions, during which TMS pulses were delivered at random or at fixed ITIs. The TMS single pulse-induced modulation of corticospinal output (motor evoked potential amplitude - MEP) was evaluated on-line. Each session began with a baseline block, followed by 10 blocks, with 20 TMS pulses each. Intra- and inter-block effects were valuated using an ANOVA model, through nested random effect on subjects considering the subject-specific variability.
Results: The delivery of successive TMS pulses significantly changed both intra-block and inter-block cortical excitability, as demonstrated by an increase in the amplitude of MEPs (p<0.001) and supported through trend analyses, showing a perfect linear trend for inter-block levels (R(2)=1) and nearly linear trend for intra-block levels (R(2)=0.97). The MEPs significantly increased when the TMS pulses were delivered at both random and fixed ITIs.
Conclusions: Single TMS pulses induce cumulative changes in neural activity during the same stimulation, resulting in a motor cortical excitability increase.
Significance: Particular attention should be taken when several single TMS pulses are delivered in research and clinical settings for diagnostic and therapeutic purposes.
(Copyright © 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.)
Titel: |
Ongoing cumulative effects of single TMS pulses on corticospinal excitability: An intra- and inter-block investigation.
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Autor/in / Beteiligte Person: | Pellicciari, MC ; Miniussi, C ; Ferrari, C ; Koch, G ; Bortoletto, M |
Zeitschrift: | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, Jg. 127 (2016), Heft 1, S. 621-628 |
Veröffentlichung: | Amsterdam : Elsevier, c1999-, 2016 |
Medientyp: | academicJournal |
ISSN: | 1872-8952 (electronic) |
DOI: | 10.1016/j.clinph.2015.03.002 |
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