Chronic liver disease: Correlation of CEUS-based microperfusion and indocyanine green clearance.
In: Clinical hemorheology and microcirculation, Jg. 61 (2015), Heft 2, S. 195-204
Online
academicJournal
Zugriff:
Purpose: To evaluate whether changes of dynamic contrast-enhanced ultrasound (CEUS)-based liver microcirculation during chronic liver disease are correlated with the extent of impaired liver function, expressed by the indocyanine green (ICG) clearance.
Materials and Methods: 19 patients underwent CEUS examinations with previous or consecutive ICG clearance test. The ICG plasma disappearance rate (ICG-PDR) was determined using the noninvasive pulse-densitometric LiMON system. Quantification of peak enhancement (PE), rise time (RT) and the wash-in rate (WiR) was performed in the liver parenchyma (ROIliver) as well as in the portal vein (ROIportal vein) using a novel quantification software (VueBoxTM). To compare quantification parameters, patients were classified in patients representing a healthy population (ICG-PDR >16, n = 8) and those representing patients with liver disease (ICG-PDR ≤16, n = 11).
Results: ROIportal vein showed significant differences comparing healthy patients and patients with liver disease for all perfusion parameters: PE and WiR were significantly higher in patients without liver disease (p = 0.048; p = 0.039). RT was significantly lower in healthy population (p = 0.039). Comparing perfusion parameters for ROIliver, PE was significantly higher in patients without liver disease (p = 0.039). There was no significant difference for RT (p = 0.804) and WiR (p = 0.058), respectively.
Conclusion: Within the framework of this study CEUS derived estimation of microcirculation did not prove to be a reliable estimator of liver function. RT, PE and WiR measured in the portal vein were significant perfusion factors in predicting liver function.
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Chronic liver disease: Correlation of CEUS-based microperfusion and indocyanine green clearance.
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Autor/in / Beteiligte Person: | Haimerl, M ; Jung, EM ; Beyer, LP ; Pregler, B ; Dollinger, M ; Sieroń, D ; Niessen, C ; Stroszczynski, C ; Wiggermann, P |
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Zeitschrift: | Clinical hemorheology and microcirculation, Jg. 61 (2015), Heft 2, S. 195-204 |
Veröffentlichung: | Amsterdam : Ios Press ; <i>Original Publication</i>: Amsterdam ; Washington, DC : IOS Press, c1997-, 2015 |
Medientyp: | academicJournal |
ISSN: | 1875-8622 (electronic) |
DOI: | 10.3233/CH-151990 |
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