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Although banned in most countries, dichlorodiphenyl-trichloroethane (DDT) continues to be used for vector control in some malaria endemic areas. Previous findings from the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort study found increased prenatal levels of DDT and its breakdown product dichlorodiphenyl-dichloroethylene (DDE) to be associated with altered neurodevelopment in children at 1 and 2years of age. In this study, we combined the measured maternal DDT/E concentrations during pregnancy obtained for the prospective birth cohort with predicted prenatal DDT and DDE levels estimated for a retrospective birth cohort. Using generalized estimating equation (GEE) and linear regression models, we evaluated the relationship of prenatal maternal DDT and DDE serum concentrations with children's cognition at ages 7 and 10.5years as assessed using the Full Scale Intelligence Quotient (IQ) and 4 subtest scores (Working Memory, Perceptual Reasoning, Verbal Comprehension, and Processing Speed) of the Wechsler Intelligence Scale for Children (WISC). In GEE analyses incorporating both age 7 and 10.5 scores (n=619), we found prenatal DDT and DDE levels were not associated with Full Scale IQ or any of the WISC subscales (p-value>0.05). In linear regression analyses assessing each time point separately, prenatal DDT levels were inversely associated with Processing Speed at age 7years (n=316), but prenatal DDT and DDE levels were not associated with Full Scale IQ or any of the WISC subscales at age 10.5years (n=595). We found evidence for effect modification by sex. In girls, but not boys, prenatal DDE levels were inversely associated with Full Scale IQ and Processing Speed at age 7years. We conclude that prenatal DDT levels may be associated with delayed Processing Speed in children at age 7years and the relationship between prenatal DDE levels and children's cognitive development may be modified by sex, with girls being more adversely affected.

Titel:	Prenatal DDT and DDE exposure and child IQ in the CHAMACOS cohort.
Autor/in / Beteiligte Person:	Gaspar, FW ; Harley, KG ; Kogut, K ; Chevrier, J ; Mora, AM ; Sjödin, A ; Eskenazi, B
Zeitschrift:	Environment international, Jg. 85 (2015-12-01), S. 206-12
Veröffentlichung:	<June 2004->: Amsterdam : Elsevier Science ; <i>Original Publication</i>: Oxford; Elmsford, N. Y., Pergamon Press., 2015
Medientyp:	academicJournal
ISSN:	1873-6750 (electronic)
DOI:	10.1016/j.envint.2015.09.004
Schlagwort:	California Child Cohort Studies DDT blood Dichlorodiphenyl Dichloroethylene blood Female Humans Male Maternal Exposure adverse effects Pregnancy Prenatal Exposure Delayed Effects blood Prenatal Exposure Delayed Effects psychology Prospective Studies Retrospective Studies Child Development drug effects Cognition drug effects DDT toxicity Dichlorodiphenyl Dichloroethylene toxicity Intelligence Tests Prenatal Exposure Delayed Effects chemically induced
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Language: English [Environ Int] 2015 Dec; Vol. 85, pp. 206-12. <i>Date of Electronic Publication: </i>2015 Sep 26. MeSH Terms: Intelligence Tests* ; Child Development / drug effects ; Cognition / drug effects ; DDT / toxicity ; Dichlorodiphenyl Dichloroethylene / toxicity ; Prenatal Exposure Delayed Effects / *chemically induced ; California ; Child ; Cohort Studies ; DDT / blood ; Dichlorodiphenyl Dichloroethylene / blood ; Female ; Humans ; Male ; Maternal Exposure / adverse effects ; Pregnancy ; Prenatal Exposure Delayed Effects / blood ; Prenatal Exposure Delayed Effects / psychology ; Prospective Studies ; Retrospective Studies References: Psychol Aging. 1997 Jun;12(2):277-87. (PMID: 9189988) ; Environ Health Perspect. 2005 Jul;113(7):894-9. (PMID: 16002379) ; Arch Environ Contam Toxicol. 1989 Jul-Aug;18(4):495-500. (PMID: 2505694) ; Prev Sci. 2007 Sep;8(3):206-13. (PMID: 17549635) ; Int J Hyg Environ Health. 2003 Aug;206(4-5):387-94. (PMID: 12971694) ; Ann Epidemiol. 1991 Aug;1(5):407-13. (PMID: 1669521) ; Environ Int. 2013 Sep;59:225-31. (PMID: 23845936) ; N Engl J Med. 1996 Sep 12;335(11):783-9. (PMID: 8703183) ; Am J Epidemiol. 2010 Mar 1;171(5):593-601. (PMID: 20106937) ; J Pediatr. 1999 Jan;134(1):33-41. (PMID: 9880446) ; Neurotoxicology. 2009 Nov;30(6):1162-5. (PMID: 19733589) ; J Expo Sci Environ Epidemiol. 2007 Jul;17(4):388-99. (PMID: 17033681) ; Am J Epidemiol. 2006 Nov 15;164(10):955-62. (PMID: 16968864) ; Environ Health Perspect. 2010 May;118(5):712-9. (PMID: 20056561) ; Environ Sci Technol. 2015 Mar 17;49(6):3940-8. (PMID: 25698216) ; Pediatrics. 2006 Jul;118(1):233-41. (PMID: 16818570) ; Environ Health Perspect. 2011 Aug;119(8):1189-95. (PMID: 21507776) ; Environ Health Perspect. 2011 Aug;119(8):1182-8. (PMID: 21507778) ; J Pediatr. 1988 Dec;113(6):991-5. (PMID: 3142988) ; Eur J Neurosci. 2008 Feb;27(4):791-800. (PMID: 18333959) ; Environ Toxicol Pharmacol. 1996 Dec 20;2(4):307-14. (PMID: 21781735) ; Child Dev. 2001 Nov-Dec;72(6):1794-813. (PMID: 11768146) ; Paediatr Perinat Epidemiol. 2005 Sep;19(5):388-98. (PMID: 16115291) ; Am J Public Health. 1987 Oct;77(10):1294-7. (PMID: 3115123) ; Neurotoxicol Teratol. 2000 Jan-Feb;22(1):21-9. (PMID: 10642111) ; Environ Health Perspect. 2004 Jul;112(10):1116-24. (PMID: 15238287) ; J Abnorm Child Psychol. 2006 Oct;34(5):585-602. (PMID: 16850284) ; Stat Appl Genet Mol Biol. 2007;6:Article25. (PMID: 17910531) ; Environ Physiol Biochem. 1974;4(5):189-99. (PMID: 4461271) ; Anal Chem. 2004 Apr 1;76(7):1921-7. (PMID: 15053652) ; Environ Health Perspect. 2007 Mar;115(3):435-9. (PMID: 17431495) ; Environ Health Perspect. 2013 Feb;121(2):263-8. (PMID: 23151722) ; Hum Reprod. 2004 Jul;19(7):1506-12. (PMID: 15131079) ; Pediatrics. 1984 Aug;74(2):246-9. (PMID: 6462822) ; Occup Environ Med. 2009 Mar;66(3):143-9. (PMID: 19060027) ; Neurotoxicology. 2000 Dec;21(6):1029-38. (PMID: 11233749) ; Int J Androl. 2006 Feb;29(1):264-71; discussion 286-90. (PMID: 16466548) ; Epidemiology. 2012 Sep;23(5):689-98. (PMID: 22766752) ; Environ Health Perspect. 2004 May;112(6):710-6. (PMID: 15121515) ; Toxicol Appl Pharmacol. 1986 Sep 15;85(2):121-7. (PMID: 3764899) ; Environ Health Perspect. 2006 May;114(5):791-7. (PMID: 16675439) ; Environ Health Perspect. 2013 Feb;121(2):257-62. (PMID: 23154064) ; J Toxicol Environ Health B Crit Rev. 2011;14(5-7):328-45. (PMID: 21790315) ; Neurotoxicology. 1990 Summer;11(2):345-54. (PMID: 2234550) ; Pediatrics. 2003 May;111(5 Pt 1):e580-5. (PMID: 12728113) ; J Pediatr. 1991 Jul;119(1 Pt 1):58-63. (PMID: 1906100) ; Med Sci Monit. 2009 Jun;15(6):RA137-45. (PMID: 19478717) Grant Information: P01 ES0009605 United States ES NIEHS NIH HHS; R01 ES015572 United States ES NIEHS NIH HHS; R01ES017054 United States ES NIEHS NIH HHS; CC999999 United States Intramural CDC HHS; R01 ES017054 United States ES NIEHS NIH HHS; R01ES015572 United States ES NIEHS NIH HHS; P01 ES009605 United States ES NIEHS NIH HHS Contributed Indexing: Keywords: Back-extrapolation; Children's health; Cognitive development; Environmental exposures; Persistent organic pollutants Substance Nomenclature: 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene) ; CIW5S16655 (DDT) Entry Date(s): Date Created: 20150929 Date Completed: 20160623 Latest Revision: 20210503 Update Code: 20240513 PubMed Central ID: PMC5152618

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Prenatal DDT and DDE exposure and child IQ in the CHAMACOS cohort.