Antidepressant-like effect of the water extract of the fixed combination of Gardenia jasminoides, Citrus aurantium and Magnolia officinalis in a rat model of chronic unpredictable mild stress.

Xing, H ; Zhang, K ; et al.

In: Phytomedicine : international journal of phytotherapy and phytopharmacology, Jg. 22 (2015-12-01), Heft 13, S. 1178-85

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Background: Water extract of the fixed combination of Gardenia jasminoides Ellis fruit, Citrus aurantium L. fruit and Magnolia officinalis Rehd. et Wils. bark, traditional name - Zhi-Zi-Hou-Po (ZZHPD) is used for treatment of depressive-like symptoms in traditional Chinese medicine for centuries.

Hypothesis/purpose: The present study aimed to explore antidepressant-like effects and potential mechanisms of ZZHPD in a rat model of chronic unpredictable mild stress (CUMS).

Study Design: Antidepressant-like effects of ZZHPD were investigated through behavioral tests, and potential mechanism was assessed by neuroendocrine system, neurotrophin and hippocampal neurogenesis.

Methods: Antidepressant-like effects of ZZHPD (3.66, 7.32 and 14.64 g/kg/day) were estimated through coat state test, sucrose preference test, forced swimming test and open-field test. Effects of ZZHPD on hypothalamic-pituitary-adrenal (HPA) axis were evaluated by hormones measurement and dexamethasone suppression test. In addition, the expression of brain-derived neurotrophic factor (BDNF) in hippocampus was measured, as well as hippocampal neurogenesis was investigated by doublecortin (DCX) and 5-bromo-2-deoxyuridine/neuronal nuclei (BrdU/NeuN).

Results: The results demonstrated that ZZHPD significantly reversed the depressive-like behaviors, normalized the levels of adrenocorticotropic hormone (ACTH) and corticosterone (CORT), restored the negative feedback loop of HPA axis and improved the levels of BDNF, DCX and BrdU/NeuN compared with those in CUMS-induced rats.

Conclusion: The above results revealed that ZZHPD exerted antidepressant-like effects possibly by normalizing HPA axis function, increasing expression of BDNF in hippocampus and promoting hippocampal neurogenesis.

Titel:	Antidepressant-like effect of the water extract of the fixed combination of Gardenia jasminoides, Citrus aurantium and Magnolia officinalis in a rat model of chronic unpredictable mild stress.
Autor/in / Beteiligte Person:	Xing, H ; Zhang, K ; Zhang, R ; Shi, H ; Bi, K ; Chen, X
Zeitschrift:	Phytomedicine : international journal of phytotherapy and phytopharmacology, Jg. 22 (2015-12-01), Heft 13, S. 1178-85
Veröffentlichung:	Stuttgart : Urban & Fischer Verlag ; <i>Original Publication</i>: Stuttgart ; New York : G. Fischer, c1994-, 2015
Medientyp:	academicJournal
ISSN:	1618-095X (electronic)
DOI:	10.1016/j.phymed.2015.09.004
Schlagwort:	Adrenocorticotropic Hormone blood Animals Antidepressive Agents isolation & purification Brain-Derived Neurotrophic Factor metabolism Citrus chemistry Corticosterone blood Disease Models, Animal Doublecortin Protein Fruit chemistry Gardenia chemistry Hippocampus drug effects Hypothalamo-Hypophyseal System drug effects Magnolia chemistry Male Molecular Structure Neurogenesis drug effects Pituitary-Adrenal System drug effects Plant Bark chemistry Rats Rats, Sprague-Dawley Antidepressive Agents pharmacology Depression drug therapy Drugs, Chinese Herbal pharmacology Iridoids pharmacology Plant Extracts pharmacology Stress, Psychological
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Phytomedicine] 2015 Dec 01; Vol. 22 (13), pp. 1178-85. <i>Date of Electronic Publication: </i>2015 Nov 16. MeSH Terms: Stress, Psychological* ; Antidepressive Agents / pharmacology ; Depression / drug therapy ; Drugs, Chinese Herbal / pharmacology ; Iridoids / pharmacology ; Plant Extracts / *pharmacology ; Adrenocorticotropic Hormone / blood ; Animals ; Antidepressive Agents / isolation & purification ; Brain-Derived Neurotrophic Factor / metabolism ; Citrus / chemistry ; Corticosterone / blood ; Disease Models, Animal ; Doublecortin Protein ; Fruit / chemistry ; Gardenia / chemistry ; Hippocampus / drug effects ; Hypothalamo-Hypophyseal System / drug effects ; Magnolia / chemistry ; Male ; Molecular Structure ; Neurogenesis / drug effects ; Pituitary-Adrenal System / drug effects ; Plant Bark / chemistry ; Rats ; Rats, Sprague-Dawley Contributed Indexing: Keywords: Antidepressant; Chronic unpredictable mild stress; Hippocampal neurogenesis; Hypothalamic-pituitary-adrenal axis; Water extract of the fixed combination of Gardenia jasminoides, Citrus aurantium and Magnolia officinalis Substance Nomenclature: 0 (Antidepressive Agents) ; 0 (Brain-Derived Neurotrophic Factor) ; 0 (Dcx protein, rat) ; 0 (Doublecortin Protein) ; 0 (Drugs, Chinese Herbal) ; 0 (Iridoids) ; 0 (Plant Extracts) ; 0 (Zhi-Zi-Hou-Pu decoction) ; 9002-60-2 (Adrenocorticotropic Hormone) ; W980KJ009P (Corticosterone) Entry Date(s): Date Created: 20151125 Date Completed: 20160111 Latest Revision: 20220330 Update Code: 20231215

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