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Background: Antibodies (Ab) to VAR2CSA prevent Plasmodium falciparum-infected erythrocytes from sequestrating in the placenta, i.e., prevent placental malaria (PM). The specificity of Ab to VAR2CSA associated with absence of PM is unknown. Accordingly, differences in the specificity of Ab to VAR2CSA were compared between multigravidae with and without PM who had Ab to VAR2CSA.

Methods: In a retrospective case-control study, plasma collected from Cameroonian multigravidae with (n = 96) and without (n = 324) PM were screened in 21 assays that measured antibody levels to full length VAR2CSA (FV2), individual VAR2CSA DBL domains, VAR2CSA domains from different genetic backgrounds (variants), as well as proportion of high avidity Ab to FV2.

Results: Multigravidae with and without PM had similar levels of Ab to FV2, the six VAR2CSA DBL domains and different variants, while the proportion of high avidity Ab to FV2 was significantly higher in women without PM at delivery (p = 0.0030) compared to women with PM. In a logistic regression model adjusted for gravidity and age, the percentage of high avidity Ab to FV2 was associated with reduced likelihood of PM in multigravidae. A 5 % increase in proportion of high avidity Ab to FV2 was associated with a nearly 15 % lower likelihood of PM.

Conclusion: Ab avidity to FV2 may be an important indicator of immunity to PM.

Titel:	Comparison of the specificity of antibodies to VAR2CSA in Cameroonian multigravidae with and without placental malaria: a retrospective case-control study.
Autor/in / Beteiligte Person:	Babakhanyan, A ; Fang, R ; Wey, A ; Salanti, A ; Sama, G ; Efundem, C ; Leke, RJ ; Chen, JJ ; Leke, RG ; Taylor, DW
Link:	Volltext (PDF) View record at Springer (Volltext)
Zeitschrift:	Malaria journal, Jg. 14 (2015-12-01), S. 480
Veröffentlichung:	London : BioMed Central, [2002-, 2015
Medientyp:	academicJournal
ISSN:	1475-2875 (electronic)
DOI:	10.1186/s12936-015-1023-6
Schlagwort:	Adult Cameroon Case-Control Studies Female Humans Male Placenta Diseases immunology Placenta Diseases prevention & control Pregnancy Retrospective Studies Young Adult Antibodies, Protozoan blood Antibody Affinity Antigens, Protozoan immunology Malaria, Falciparum immunology Pregnancy Complications, Infectious immunology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Language: English [Malar J] 2015 Dec 01; Vol. 14, pp. 480. <i>Date of Electronic Publication: </i>2015 Dec 01. MeSH Terms: Antibody Affinity* ; Antibodies, Protozoan / blood ; Antigens, Protozoan / immunology ; Malaria, Falciparum / immunology ; Pregnancy Complications, Infectious / immunology ; Adult ; Cameroon ; Case-Control Studies ; Female ; Humans ; Male ; Placenta Diseases / immunology ; Placenta Diseases / prevention & control ; Pregnancy ; Retrospective Studies ; Young Adult References: Eur J Immunol. 2002 Mar;32(3):752-60. (PMID: 11870619) ; Infect Immun. 2003 Nov;71(11):6620-3. (PMID: 14573685) ; Am J Trop Med Hyg. 2003 Dec;69(6):574-81. (PMID: 14740871) ; Tropenmed Parasitol. 1976 Sep;27(3):385-90. (PMID: 790706) ; Science. 1989 Jun 9;244(4909):1152-7. (PMID: 2658060) ; Nature. 1991 Aug 8;352(6335):530-2. (PMID: 1907716) ; Cell. 1991 Dec 20;67(6):1121-9. (PMID: 1760840) ; Bull Soc Pathol Exot. 1992;85(1):26-30. (PMID: 1596954) ; Clin Exp Immunol. 1992 Aug;89(2):296-300. (PMID: 1638773) ; Bull Soc Pathol Exot. 1993;86(1):56-61. (PMID: 8504265) ; J Exp Med. 1993 Jul 1;178(1):295-307. (PMID: 8315385) ; Mem Inst Oswaldo Cruz. 1992;87 Suppl 3:229-34. (PMID: 1343695) ; Am J Trop Med Hyg. 1996 Sep;55(3):315-23. (PMID: 8842122) ; Nature. 1998 Oct 29;395(6705):851-2. (PMID: 9804416) ; Biochemistry. 1964 Jul;3:996-1008. (PMID: 14214095) ; PLoS One. 2012;7(2):e32242. (PMID: 22363818) ; Infect Immun. 2012 Apr;80(4):1479-90. (PMID: 22331427) ; PLoS One. 2012;7(6):e40049. (PMID: 22761948) ; J Biol Chem. 2012 Jul 6;287(28):23332-45. (PMID: 22570492) ; Vaccine. 2013 Jan 2;31(2):387-93. (PMID: 23142306) ; PLoS One. 2012;7(12):e52939. (PMID: 23300828) ; Infect Immun. 2013 Apr;81(4):1031-9. (PMID: 23319559) ; Infect Immun. 2014 Jun;82(6):2565-73. (PMID: 24686068) ; Infect Immun. 2014 Nov;82(11):4842-53. (PMID: 25156731) ; Malar J. 2015;14:72. (PMID: 25885325) ; Emerg Infect Dis. 2015 May;21(5):813-23. (PMID: 25898123) ; Infect Immun. 2015 Jun;83(6):2466-74. (PMID: 25824842) ; PLoS One. 2015;10(9):e0135406. (PMID: 26327283) ; J Nutr. 2001 Feb;131(2S-2):636S-645S; discussion 646S-648S. (PMID: 11160595) ; J Infect Dis. 2001 Sep 1;184(5):618-26. (PMID: 11494167) ; Infect Immun. 2001 Dec;69(12):7487-92. (PMID: 11705924) ; J Infect Dis. 2009 Jul 15;200(2):299-306. (PMID: 19500037) ; PLoS Med. 2010 Jan;7(1):e1000221. (PMID: 20126256) ; PLoS One. 2010;5(2):e9230. (PMID: 20169064) ; J Mol Biol. 2010 Apr 2;397(3):826-34. (PMID: 20109466) ; Parasite Immunol. 2010 Apr;32(4):296-304. (PMID: 20398230) ; J Immunol. 2010 Dec 15;185(12):7553-61. (PMID: 21078904) ; Am J Trop Med Hyg. 2005 Mar;72(3):236-42. (PMID: 15772313) ; Infect Immun. 2005 Jul;73(7):4112-8. (PMID: 15972500) ; Clin Vaccine Immunol. 2006 Dec;13(12):1307-13. (PMID: 17035513) ; PLoS Med. 2007 May;4(5):e181. (PMID: 17535103) ; Am J Trop Med Hyg. 2007 Jul;77(1):22-8. (PMID: 17620626) ; Mol Biochem Parasitol. 2007 Oct;155(2):103-12. (PMID: 17669514) ; Clin Vaccine Immunol. 2007 Oct;14(10):1362-9. (PMID: 17699836) ; Malar J. 2008;7:10. (PMID: 18190692) ; Infect Immun. 2008 Apr;76(4):1791-800. (PMID: 18250177) ; Malar J. 2008;7:186. (PMID: 18816374) ; PLoS One. 2011;6(7):e22491. (PMID: 21811621) ; J Infect Dis. 2012 Feb 15;205(4):610-20. (PMID: 22207649) ; PLoS One. 2012;7(1):e31011. (PMID: 22295123) Grant Information: G12 MD007601 United States MD NIMHD NIH HHS; U01 AI043888 United States AI NIAID NIH HHS; R21 AI105286 United States AI NIAID NIH HHS; G12MD007601 United States MD NIMHD NIH HHS; R21AI105286-01 United States AI NIAID NIH HHS; UO1AI43888 United States AI NIAID NIH HHS; U54MD007584 United States MD NIMHD NIH HHS; U54 MD007584 United States MD NIMHD NIH HHS; R01AI071160 United States AI NIAID NIH HHS; R01 AI071160 United States AI NIAID NIH HHS; R25 TW009345 United States TW FIC NIH HHS Substance Nomenclature: 0 (Antibodies, Protozoan) ; 0 (Antigens, Protozoan) ; 0 (VAR2CSA protein, Plasmodium falciparum) Entry Date(s): Date Created: 20151203 Date Completed: 20160622 Latest Revision: 20181113 Update Code: 20240513 PubMed Central ID: PMC4666123

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Comparison of the specificity of antibodies to VAR2CSA in Cameroonian multigravidae with and without placental malaria: a retrospective case-control study.