Investigation of the association of Vogt-Koyanagi-Harada syndrome with IL23R-C1orf141 in Han Chinese Singaporean and ADO-ZNF365-EGR2 in Thai.

Cao, S ; Chee, SP ; et al.

In: The British journal of ophthalmology, Jg. 100 (2016-03-01), Heft 3, S. 436-42

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Background: We performed a multistage genome-wide association study of Vogt-Koyanagi-Harada (VKH) syndrome in a Han Chinese population and identified two novel non-human leukocyte antigen candidate regions previously. The aim of the study was to replicate the association of IL23R-C1orf141 and ADO-ZNF365-EGR2 with VKH syndrome in four sets of multinational populations in Asia.

Method: We conducted a candidate genes association study involving 185 patients with VKH syndrome and 287 normal controls from Han Chinese Singaporeans, non-Han Chinese, Thais and Koreans. Genotyping of 16 single nucleotide polymorphisms (SNPs) within IL23R-C1orf141 and ADO-ZNF365-EGR2 loci was performed using the Sequenom MassARRAY system or by Taqman SNP assays.

Results: Eight SNPs in IL23R-Clorf141 showed an association with VKH syndrome only in Han Chinese Singaporeans (p=8.49×10(-5) to 1.02×10(-3), pcorrection=1.69×10(-4) to 2.04×10(-3)) but not in the other groups tested. One SNP rs1884444 in IL23R-Clorf141 was found to be weakly associated with VKH syndrome in the Han Chinese Singaporeans, but significance was lost following Bonferroni correction for multiple comparisons. Five SNPs in ADO-ZNF365-EGR2 were found to be associated with VKH syndrome in Thai patients with VKH (p=0.014, pc=0.028) but not in the other three ethnic groups tested.

Conclusions: This study confirmed the genetic associations between SNPs in IL23R-C1orf141 and VKH syndrome in Han Chinese Singaporeans but not in other Asian populations. In addition, we also successfully replicated the association of VKH syndrome with ADO-ZNF365-EGR2 in a Thai population.

(Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/)

Titel:	Investigation of the association of Vogt-Koyanagi-Harada syndrome with IL23R-C1orf141 in Han Chinese Singaporean and ADO-ZNF365-EGR2 in Thai.
Autor/in / Beteiligte Person:	Cao, S ; Chee, SP ; Yu, HG ; Sukavatcharin, S ; Wu, L ; Kijlstra, A ; Hou, S ; Yang, P
Link:	Full Text Finder (Volltext)
Zeitschrift:	The British journal of ophthalmology, Jg. 100 (2016-03-01), Heft 3, S. 436-42
Veröffentlichung:	Jan. 1992- : London : BMJ Pub. Group ; <i>Original Publication</i>: 1917-Dec. 1991: London : British Medical Association, 2016
Medientyp:	academicJournal
ISSN:	1468-2079 (electronic)
DOI:	10.1136/bjophthalmol-2015-307366
Schlagwort:	Adult Aged Carotenoids genetics Case-Control Studies China epidemiology DNA-Binding Proteins genetics Early Growth Response Protein 2 genetics Female Genetic Predisposition to Disease Genome-Wide Association Study Genotyping Techniques Humans Korea epidemiology Male Middle Aged Open Reading Frames genetics Oxygenases genetics Polymerase Chain Reaction Receptors, Interleukin genetics Singapore epidemiology Thailand epidemiology Transcription Factors genetics Uveomeningoencephalitic Syndrome ethnology Asian People genetics Chromosomes, Human, Pair 1 genetics Chromosomes, Human, Pair 10 genetics Eye Proteins genetics Polymorphism, Single Nucleotide Uveomeningoencephalitic Syndrome genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Br J Ophthalmol] 2016 Mar; Vol. 100 (3), pp. 436-42. <i>Date of Electronic Publication: </i>2015 Dec 01. MeSH Terms: Polymorphism, Single Nucleotide* ; Asian People / genetics ; Chromosomes, Human, Pair 1 / genetics ; Chromosomes, Human, Pair 10 / genetics ; Eye Proteins / genetics ; Uveomeningoencephalitic Syndrome / *genetics ; Adult ; Aged ; Carotenoids / genetics ; Case-Control Studies ; China / epidemiology ; DNA-Binding Proteins / genetics ; Early Growth Response Protein 2 / genetics ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genotyping Techniques ; Humans ; Korea / epidemiology ; Male ; Middle Aged ; Open Reading Frames / genetics ; Oxygenases / genetics ; Polymerase Chain Reaction ; Receptors, Interleukin / genetics ; Singapore / epidemiology ; Thailand / epidemiology ; Transcription Factors / genetics ; Uveomeningoencephalitic Syndrome / ethnology Contributed Indexing: Keywords: Genetics Substance Nomenclature: 0 (DNA-Binding Proteins) ; 0 (EGR2 protein, human) ; 0 (Early Growth Response Protein 2) ; 0 (Eye Proteins) ; 0 (IL23R protein, human) ; 0 (Receptors, Interleukin) ; 0 (Transcription Factors) ; 0 (ZNF365 protein, human) ; 0 (beta-apocarotenoid-14',13'-dioxygenase) ; 36-88-4 (Carotenoids) ; EC 1.13.- (Oxygenases) Entry Date(s): Date Created: 20151203 Date Completed: 20160708 Latest Revision: 20221207 Update Code: 20231215

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