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The role of brain-derived neurotrophic factor (BDNF) is to promote and modulate neuronal responses across neurotransmitter systems in the brain. Therefore, abnormal BDNF signaling may be associated with the pathophysiology of schizophrenia. Low BDNF levels have been reported in brains and serums of patients with psychotic disorders. In the present study, we investigated the effects of antiepileptic drugs on BDNF in developing rats. Pregnant rats were treated with phenytoin (PHT), lamotrigine (LTG) and folic acid for long-term, all through their gestational periods. Experimental epilepsy (EE) model was applied in pregnant rats. Epileptic seizures were determined with electroencephalography. After birth, serum BDNF levels were measured in 136 newborn rats on postnatal day (PND) 21 and postnatal day 38. In postnatal day 21, serum BDNF levels of experimental epilepsy group were significantly lower compared with PHT group. This decrease is statistically significant. Serum BDNF levels increased in the group LTG. This increase compared with LTG+EE group was statistically significant. In the folic acid (FA) group, levels of serum BDNF decreased statistically significantly compared to the PHT group. On postnatal day 38, no significant differences were found among the groups for serum BDNF levels. We concluded that, the passed seizures during pregnancy adversely affect fetal brain development, lowering of serum BDNF levels. PHT use during pregnancy prevents seizure-induced injury by increasing the levels of BDNF. About the increase level of BDNF, LTG is much less effective than PHT, the positive effect of folic acid on serum BDNF levels was not observed. LTG increase in BDNF is much less effective than PHT, folic acid did not show a positive effect on serum BDNF levels. Epilepsy affects fetal brain development during gestation in pregnant rats, therefore anti-epileptic therapy should be continued during pregnancy.

Titel:	Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats.
Autor/in / Beteiligte Person:	Soysal, H ; Doğan, Z ; Kamışlı, Ö
Zeitschrift:	Neuropeptides, Jg. 56 (2016-04-01), S. 1-8
Veröffentlichung:	2002- : Amsterdam : Elsevier ; <i>Original Publication</i>: Edinburgh ; New York : Churchill Livingstone, c1980-, 2016
Medientyp:	academicJournal
ISSN:	1532-2785 (electronic)
DOI:	10.1016/j.npep.2015.12.001
Schlagwort:	Animals Cerebral Cortex physiopathology Disease Models, Animal Electroencephalography Epilepsy physiopathology Female Lamotrigine Pregnancy Rats Rats, Wistar Brain-Derived Neurotrophic Factor blood Epilepsy blood Folic Acid administration & dosage Phenytoin administration & dosage Prenatal Exposure Delayed Effects blood Triazines administration & dosage
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [Neuropeptides] 2016 Apr; Vol. 56, pp. 1-8. <i>Date of Electronic Publication: </i>2015 Dec 08. MeSH Terms: Brain-Derived Neurotrophic Factor / blood ; Epilepsy / blood ; Folic Acid / administration & dosage ; Phenytoin / administration & dosage ; Prenatal Exposure Delayed Effects / blood ; Triazines / administration & dosage ; Animals ; Cerebral Cortex / physiopathology ; Disease Models, Animal ; Electroencephalography ; Epilepsy / physiopathology ; Female ; Lamotrigine ; Pregnancy ; Rats ; Rats, Wistar Contributed Indexing: Keywords: BDNF; Epilepsy; Folic acid; Lamotrigine; Phenytoin Substance Nomenclature: 0 (Brain-Derived Neurotrophic Factor) ; 0 (Triazines) ; 6158TKW0C5 (Phenytoin) ; 935E97BOY8 (Folic Acid) ; U3H27498KS (Lamotrigine) Entry Date(s): Date Created: 20151227 Date Completed: 20161221 Latest Revision: 20181202 Update Code: 20231215

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Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats.