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Mitochondria undergo fragmentation in response to electron transport chain (ETC) poisons and mitochondrial DNA-linked disease mutations, yet how these stimuli mechanistically connect to the mitochondrial fission and fusion machinery is poorly understood. We found that the energy-sensing adenosine monophosphate (AMP)-activated protein kinase (AMPK) is genetically required for cells to undergo rapid mitochondrial fragmentation after treatment with ETC inhibitors. Moreover, direct pharmacological activation of AMPK was sufficient to rapidly promote mitochondrial fragmentation even in the absence of mitochondrial stress. A screen for substrates of AMPK identified mitochondrial fission factor (MFF), a mitochondrial outer-membrane receptor for DRP1, the cytoplasmic guanosine triphosphatase that catalyzes mitochondrial fission. Nonphosphorylatable and phosphomimetic alleles of the AMPK sites in MFF revealed that it is a key effector of AMPK-mediated mitochondrial fission.

Titel:	Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress.
Autor/in / Beteiligte Person:	Toyama, EQ ; Herzig, S ; Courchet, J ; Lewis TL Jr ; Losón, OC ; Hellberg, K ; Young, NP ; Chen, H ; Polleux, F ; Chan, DC ; Shaw, RJ
Link:	Volltext (PDF)
Zeitschrift:	Science (New York, N.Y.), Jg. 351 (2016-01-15), Heft 6270, S. 275-281
Veröffentlichung:	<Oct. 4, 1991- > : Washington, DC : American Association for the Advancement of Science ; <i>Original Publication</i>: New York, N.Y. : [s.n.] 1880-, 2016
Medientyp:	academicJournal
ISSN:	1095-9203 (electronic)
DOI:	10.1126/science.aab4138
Schlagwort:	AMP-Activated Protein Kinases chemistry AMP-Activated Protein Kinases genetics Adenosine Monophosphate metabolism Amino Acid Motifs Cell Line, Tumor Cytoplasm enzymology Dactinomycin analogs & derivatives Dactinomycin pharmacology Dynamins Enzyme Activation GTP Phosphohydrolases genetics GTP Phosphohydrolases metabolism Humans Microtubule-Associated Proteins genetics Microtubule-Associated Proteins metabolism Mitochondria drug effects Mitochondria enzymology Mitochondrial Proteins genetics Mitochondrial Proteins metabolism Molecular Sequence Data Rotenone pharmacology AMP-Activated Protein Kinases metabolism Energy Metabolism Mitochondria physiology Mitochondrial Dynamics Stress, Physiological
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Language: English [Science] 2016 Jan 15; Vol. 351 (6270), pp. 275-281. MeSH Terms: Energy Metabolism* ; Mitochondrial Dynamics* ; Stress, Physiological* ; AMP-Activated Protein Kinases / metabolism ; Mitochondria / physiology ; AMP-Activated Protein Kinases / chemistry ; AMP-Activated Protein Kinases / genetics ; Adenosine Monophosphate / metabolism ; Amino Acid Motifs ; Cell Line, Tumor ; Cytoplasm / enzymology ; Dactinomycin / analogs & derivatives ; Dactinomycin / pharmacology ; Dynamins ; Enzyme Activation ; GTP Phosphohydrolases / genetics ; GTP Phosphohydrolases / metabolism ; Humans ; Microtubule-Associated Proteins / genetics ; Microtubule-Associated Proteins / metabolism ; Mitochondria / drug effects ; Mitochondria / enzymology ; Mitochondrial Proteins / genetics ; Mitochondrial Proteins / metabolism ; Molecular Sequence Data ; Rotenone / pharmacology Comments: Comment in: Nature. 2016 Feb 18;530(7590):288-9. (PMID: 26887490) ; Comment in: Cell Metab. 2016 Mar 8;23(3):399-401. (PMID: 26959181) References: Cell Metab. 2005 Jan;1(1):15-25. (PMID: 16054041) ; Nat Rev Mol Cell Biol. 2005 Aug;6(8):657-63. (PMID: 16025099) ; Cell Metab. 2006 Jun;3(6):403-16. (PMID: 16753576) ; Mol Cell Biol. 2006 Jul;26(14):5336-47. (PMID: 16809770) ; EMBO J. 2006 Jul 12;25(13):2966-77. (PMID: 16778770) ; J Biol Chem. 2006 Dec 8;281(49):37972-9. (PMID: 17003040) ; J Cell Sci. 2007 Mar 1;120(Pt 5):838-48. (PMID: 17298981) ; J Cell Biol. 2007 Dec 17;179(6):1163-77. (PMID: 18086914) ; EMBO J. 2008 Jan 23;27(2):433-46. (PMID: 18200046) ; Mol Cell. 2008 Apr 25;30(2):214-26. (PMID: 18439900) ; Mol Biol Cell. 2008 Jun;19(6):2402-12. (PMID: 18353969) ; J Cell Biol. 2009 Dec 28;187(7):959-66. (PMID: 20038677) ; J Cell Biol. 2009 Dec 28;187(7):1023-36. (PMID: 20038678) ; Cell. 2010 Sep 17;142(6):889-901. (PMID: 20850011) ; J Cell Biol. 2010 Dec 13;191(6):1141-58. (PMID: 21149567) ; Science. 2011 Jan 28;331(6016):456-61. (PMID: 21205641) ; Nat Cell Biol. 2011 Feb;13(2):132-41. (PMID: 21258367) ; Cell Metab. 2011 Apr 6;13(4):376-88. (PMID: 21459323) ; Nat Cell Biol. 2011 May;13(5):589-98. (PMID: 21478857) ; Cell. 2011 May 13;145(4):607-21. (PMID: 21565617) ; Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10190-5. (PMID: 21646527) ; Nat Cell Biol. 2011 Sep;13(9):1016-23. (PMID: 21892142) ; Science. 2012 Aug 31;337(6098):1062-5. (PMID: 22936770) ; Mol Biol Cell. 2013 Mar;24(5):659-67. (PMID: 23283981) ; Cell Metab. 2013 Apr 2;17(4):491-506. (PMID: 23562075) ; J Cell Sci. 2013 Feb 1;126(Pt 3):789-802. (PMID: 23239023) ; Neuron. 2013 Apr 10;78(1):94-108. (PMID: 23583109) ; Cell. 2013 Jun 20;153(7):1510-25. (PMID: 23791179) ; Nat Commun. 2013;4:3017. (PMID: 24352254) ; Mol Biol Cell. 2014 Jan;25(1):145-59. (PMID: 24196833) ; EMBO Mol Med. 2014 Apr;6(4):519-38. (PMID: 24497570) ; Cell Metab. 2014 Apr 1;19(4):630-41. (PMID: 24703695) ; Structure. 2014 Aug 5;22(8):1161-72. (PMID: 25066137) ; Science. 2014 Sep 19;345(6203):1250256. (PMID: 25237106) ; Nat Rev Mol Cell Biol. 2014 Oct;15(10):634-46. (PMID: 25237825) ; Cell Signal. 2015 May;27(5):978-88. (PMID: 25683918) ; Dev Cell. 2015 Mar 23;32(6):678-92. (PMID: 25752962) ; J Mol Biol. 2002 Mar 22;317(2):309-23. (PMID: 11902845) ; J Cell Biol. 2002 Dec 23;159(6):931-8. (PMID: 12499352) Grant Information: K99NS091526 United States NS NINDS NIH HHS; R01CA172229 United States CA NCI NIH HHS; R01NS089456 United States NS NINDS NIH HHS; R01 DK080425 United States DK NIDDK NIH HHS; R01 GM110039 United States GM NIGMS NIH HHS; P01 CA120964 United States CA NCI NIH HHS; R01 CA172229 United States CA NCI NIH HHS; K99 NS091526 United States NS NINDS NIH HHS; R01 GM062967 United States GM NIGMS NIH HHS; R01 NS089456 United States NS NINDS NIH HHS; R01GM110039 United States GM NIGMS NIH HHS; R01GM062967 United States GM NIGMS NIH HHS; United States Howard Hughes Medical Institute; R01DK080425 United States DK NIDDK NIH HHS; P30 CA014195 United States CA NCI NIH HHS Substance Nomenclature: 0 (Microtubule-Associated Proteins) ; 0 (Mitochondrial Proteins) ; 03L9OT429T (Rotenone) ; 0OCC969V50 (cactinomycin) ; 1CC1JFE158 (Dactinomycin) ; 415SHH325A (Adenosine Monophosphate) ; EC 2.7.11.31 (AMP-Activated Protein Kinases) ; EC 3.6.1.- (GTP Phosphohydrolases) ; EC 3.6.5.5 (DNM1L protein, human) ; EC 3.6.5.5 (Dynamins) Entry Date(s): Date Created: 20160128 Date Completed: 20160216 Latest Revision: 20220410 Update Code: 20231215 PubMed Central ID: PMC4852862

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Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress.