Prostate Cancer Susceptibility in Men of African Ancestry at 8q24.
In: Journal of the National Cancer Institute, Jg. 108 (2016-01-27), Heft 7
Online
academicJournal
Zugriff:
The 8q24 region harbors multiple risk variants for distinct cancers, including >8 for prostate cancer. In this study, we conducted fine mapping of the 8q24 risk region (127.8-128.8Mb) in search of novel associations with common and rare variation in 4853 prostate cancer case patients and 4678 control subjects of African ancestry. All statistical tests were two-sided. We identified three independent associations at P values of less than 5.00×10(-8), all of which were replicated in studies from Ghana and Uganda (combined sample = 5869 case patients, 5615 control subjects; rs114798100: risk allele frequency [RAF] = 0.04, per-allele odds ratio [OR] = 2.31, 95% confidence interval [CI] = 2.04 to 2.61, P = 2.38×10(-40); rs72725879: RAF = 0.33, OR = 1.37, 95% CI = 1.30 to 1.45, P = 3.04×10(-27); and rs111906932: RAF = 0.03, OR = 1.79, 95% CI = 1.53 to 2.08, P = 1.39×10(-13)). Risk variants rs114798100 and rs111906923 are only found in men of African ancestry, with rs111906923 representing a novel association signal. The three variants are located within or near a number of prostate cancer-associated long noncoding RNAs (lncRNAs), including PRNCR1, PCAT1, and PCAT2. These findings highlight ancestry-specific risk variation and implicate prostate-specific lncRNAs at the 8q24 prostate cancer susceptibility region.
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| Titel: |
Prostate Cancer Susceptibility in Men of African Ancestry at 8q24.
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| Autor/in / Beteiligte Person: | Han, Y ; Rand, KA ; Hazelett, DJ ; Ingles, SA ; Kittles, RA ; Strom, SS ; Rybicki, BA ; Nemesure, B ; Isaacs, WB ; Stanford, JL ; Zheng, W ; Schumacher, FR ; Berndt, SI ; Wang, Z ; Xu, J ; Rohland, N ; Reich, D ; Tandon, A ; Pasaniuc, B ; Allen, A ; Quinque, D ; Mallick, S ; Notani, D ; Rosenfeld, MG ; Jayani, RS ; Kolb, S ; Gapstur, SM ; Stevens, VL ; Pettaway, CA ; Yeboah, ED ; Tettey, Y ; Biritwum, RB ; Adjei, AA ; Tay, E ; Truelove, A ; Niwa, S ; Chokkalingam, AP ; John, EM ; Murphy, AB ; Signorello, LB ; Carpten, J ; Leske, MC ; Wu, SY ; Hennis, AJM ; Neslund-Dudas, C ; Hsing, AW ; Chu, L ; Goodman, PJ ; Klein, EA ; Zheng, SL ; Witte, JS ; Casey, G ; Lubwama, A ; Pooler, LC ; Sheng, X ; Coetzee, GA ; Cook, MB ; Chanock, SJ ; Stram, DO ; Watya, S ; Blot, WJ ; Conti, DV ; Henderson, BE ; Haiman, CA |
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| Zeitschrift: | Journal of the National Cancer Institute, Jg. 108 (2016-01-27), Heft 7 |
| Veröffentlichung: | <2003-> : Cary, NC : Oxford University Press ; <i>Original Publication</i>: Bethesda, Md., U. S. Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health; Washington, for sale by the Supt. of Docs., U. S. Govt. Print. Off., 2016 |
| Medientyp: | academicJournal |
| ISSN: | 1460-2105 (electronic) |
| DOI: | 10.1093/jnci/djv431 |
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