Importin-7 mediates memory consolidation through regulation of nuclear translocation of training-activated MAPK in Drosophila.
In: Proceedings of the National Academy of Sciences of the United States of America, Jg. 113 (2016-03-15), Heft 11, S. 3072-7
Online
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Zugriff:
Translocation of signaling molecules, MAPK in particular, from the cytosol to nucleus represents a universal key element in initiating the gene program that determines memory consolidation. Translocation mechanisms and their behavioral impact, however, remain to be determined. Here, we report that a highly conserved nuclear transporter, Drosophila importin-7 (DIM-7), regulates import of training-activated MAPK for consolidation of long-term memory (LTM). We show that silencing DIM-7 functions results in impaired LTM, whereas overexpression of DIM-7 enhances LTM. This DIM-7-dependent regulation of LTM is confined to a consolidation time window and in mushroom body neurons. Image data show that bidirectional alteration in DIM-7 expression results in proportional changes in the intensity of training-activated MAPK accumulated within the nuclei of mushroom body neurons during LTM consolidation. Such DIM-7-regulated nuclear accumulation of activated MAPK is observed only in the training specified for LTM induction and determines the amplitude, but not the time course, of memory consolidation.
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Importin-7 mediates memory consolidation through regulation of nuclear translocation of training-activated MAPK in Drosophila.
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Autor/in / Beteiligte Person: | Li, Q ; Zhang, X ; Hu, W ; Liang, X ; Zhang, F ; Wang, L ; Liu, ZJ ; Zhong, Y |
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Zeitschrift: | Proceedings of the National Academy of Sciences of the United States of America, Jg. 113 (2016-03-15), Heft 11, S. 3072-7 |
Veröffentlichung: | Washington, DC : National Academy of Sciences, 2016 |
Medientyp: | academicJournal |
ISSN: | 1091-6490 (electronic) |
DOI: | 10.1073/pnas.1520401113 |
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