Aqueous leaf extract of Passiflora alata Curtis promotes antioxidant and anti-inflammatory effects and consequently preservation of NOD mice beta cells (non-obese diabetic).

Figueiredo, D ; Colomeu, TC ; et al.

In: International immunopharmacology, Jg. 35 (2016-06-01), S. 127-136

academicJournal

Passiflora alata Curtis (P. alata) leaves have anti-inflammatory properties; the present study aimed to investigate the anti-diabetogenic properties of P. alata aqueous leaf extract. HPLC analysis identified the phenolic compounds catechin, epicatechin and rutin. The aqueous extract was administered for 30weeks to non-obese diabetic (NOD) mice presenting a decrease of 28.6% in diabetes incidence and the number of inflammatory cells in pancreatic islets, when compared with the control group (water). The P. alata group presented an antioxidant effect and decreased lipid peroxidation in the serum of NOD mice. Increased numbers of insulin-positive cells were also observed in the pancreatic islets of the treated group. The diabetic group exhibited higher levels in the glucose tolerance test and glycemic index, in comparison to the P. alata-treated group and non-diabetic control BALB/c mice. In addition, the P. alata extract reduced the percentage and the proliferation index of NOD mice lymphocytes submitted to in vitro dose/response mitogenic stimulation assays. These results suggest that the aqueous extract of P. alata has anti-inflammatory properties, contributing to the protection of beta cells in pancreatic islets in NOD mice, and presents potential for use a supporting approach to treat type 1 diabetes.

Titel:	Aqueous leaf extract of Passiflora alata Curtis promotes antioxidant and anti-inflammatory effects and consequently preservation of NOD mice beta cells (non-obese diabetic).
Autor/in / Beteiligte Person:	Figueiredo, D ; Colomeu, TC ; Schumacher, NSG ; Stivanin-Silva, LG ; Cazarin, CBB ; Meletti, LMM ; Fernandes, LGR ; Prado, MA ; Zollner, RL
Zeitschrift:	International immunopharmacology, Jg. 35 (2016-06-01), S. 127-136
Veröffentlichung:	Amsterdam ; New York : Elsevier Science, c2001-, 2016
Medientyp:	academicJournal
ISSN:	1878-1705 (electronic)
DOI:	10.1016/j.intimp.2016.03.031
Schlagwort:	Animals Cells, Cultured Cytoprotection Female Humans Insulin blood Insulin-Secreting Cells physiology Lipid Peroxidation drug effects Lymphocyte Activation drug effects Mice Mice, Inbred BALB C Mice, Inbred NOD Plant Leaves Anti-Inflammatory Agents therapeutic use Antioxidants therapeutic use Diabetes Mellitus, Type 1 drug therapy Insulin-Secreting Cells drug effects Passiflora immunology Plant Extracts therapeutic use
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Int Immunopharmacol] 2016 Jun; Vol. 35, pp. 127-136. <i>Date of Electronic Publication: </i>2016 Apr 16. MeSH Terms: Anti-Inflammatory Agents / therapeutic use ; Antioxidants / therapeutic use ; Diabetes Mellitus, Type 1 / drug therapy ; Insulin-Secreting Cells / drug effects ; Passiflora / immunology ; Plant Extracts / therapeutic use ; Animals ; Cells, Cultured ; Cytoprotection ; Female ; Humans ; Insulin / blood ; Insulin-Secreting Cells / physiology ; Lipid Peroxidation / drug effects ; Lymphocyte Activation / drug effects ; Mice ; Mice, Inbred BALB C ; Mice, Inbred NOD ; Plant Leaves Contributed Indexing: Keywords: Anti-inflammatory effect; NOD mice; Passiflora alata Curtis; Type 1 diabetes mellitus Substance Nomenclature: 0 (Anti-Inflammatory Agents) ; 0 (Antioxidants) ; 0 (Insulin) ; 0 (Plant Extracts) Entry Date(s): Date Created: 20160404 Date Completed: 20170404 Latest Revision: 20170714 Update Code: 20240513

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.