Einzeltreffer — DigiBib

Rationale: Lithium remains the most effective treatment for bipolar disorder and also has important effects to lower suicidal behaviour, a property that may be linked to its ability to diminish impulsive, aggressive behaviour. The antioxidant drug, ebselen, has been proposed as a possible lithium-mimetic based on its ability in animals to inhibit inositol monophosphatase (IMPase), an action which it shares with lithium.

Objectives: The aim of the study was to determine whether treatment with ebselen altered emotional processing and diminished measures of risk-taking behaviour.

Methods: We studied 20 healthy participants who were tested on two occasions receiving either ebselen (3600 mg over 24 h) or identical placebo in a double-blind, randomized, cross-over design. Three hours after the final dose of ebselen/placebo, participants completed the Cambridge Gambling Task (CGT) and a task that required the detection of emotional facial expressions (facial emotion recognition task (FERT)).

Results: On the CGT, relative to placebo, ebselen reduced delay aversion while on the FERT, it increased the recognition of positive vs negative facial expressions.

Conclusions: The study suggests that at the dosage used, ebselen can decrease impulsivity and produce a positive bias in emotional processing. These findings have implications for the possible use of ebselen in the disorders characterized by impulsive behaviour and dysphoric mood.

Titel:	Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.
Autor/in / Beteiligte Person:	Masaki, C ; Sharpley, AL ; Cooper, CM ; Godlewska, BR ; Singh, N ; Vasudevan, SR ; Harmer, CJ ; Churchill, GC ; Sharp, T ; Rogers, RD ; Cowen, PJ
Link:	Volltext (PDF) View record at Springer (Volltext)
Zeitschrift:	Psychopharmacology, Jg. 233 (2016-07-01), Heft 14, S. 2655-61
Veröffentlichung:	Berlin, New York, Springer-Verlag., 2016
Medientyp:	academicJournal
ISSN:	1432-2072 (electronic)
DOI:	10.1007/s00213-016-4319-5
Schlagwort:	Adult Analysis of Variance Animals Bipolar Disorder drug therapy Cross-Over Studies Decision Making drug effects Double-Blind Method Facial Expression Female Humans Isoindoles Male Phosphoric Monoester Hydrolases Reward Risk-Taking Young Adult Azoles pharmacology Cyclooxygenase Inhibitors pharmacology Emotions drug effects Impulsive Behavior drug effects Neuroprotective Agents pharmacology Organoselenium Compounds pharmacology Recognition, Psychology drug effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Randomized Controlled Trial Language: English [Psychopharmacology (Berl)] 2016 Jul; Vol. 233 (14), pp. 2655-61. <i>Date of Electronic Publication: </i>2016 Jun 02. MeSH Terms: Azoles / pharmacology ; Cyclooxygenase Inhibitors / pharmacology ; Emotions / drug effects ; Impulsive Behavior / drug effects ; Neuroprotective Agents / pharmacology ; Organoselenium Compounds / pharmacology ; Recognition, Psychology / drug effects ; Adult ; Analysis of Variance ; Animals ; Bipolar Disorder / drug therapy ; Cross-Over Studies ; Decision Making / drug effects ; Double-Blind Method ; Facial Expression ; Female ; Humans ; Isoindoles ; Male ; Phosphoric Monoester Hydrolases ; Reward ; Risk-Taking ; Young Adult References: Psychopharmacology (Berl). 2016 Mar;233(6):1097-104. (PMID: 26758281) ; J Psychopharmacol. 2011 Sep;25(9):1159-67. (PMID: 20660010) ; Psychol Med. 2001 May;31(4):679-93. (PMID: 11352370) ; Neurosci Biobehav Rev. 2007;31(6):932-62. (PMID: 17532044) ; Neuropsychopharmacology. 2016 Jun;41(7):1768-78. (PMID: 26593266) ; J Affect Disord. 2015 Jun 1;178:18-24. (PMID: 25770479) ; Psychopharmacology (Berl). 2012 Jan;219(2):421-32. (PMID: 21947315) ; Nat Rev Neurosci. 2011 Jul 06;12 (8):467-77. (PMID: 21731066) ; Br J Psychiatry. 1987 May;150:685-9. (PMID: 3115350) ; Psychopharmacology (Berl). 2008 Sep;199(4):495-502. (PMID: 18575851) ; Cell. 1989 Nov 3;59(3):411-9. (PMID: 2553271) ; Cognition. 1997 Jun;63(3):271-313. (PMID: 9265872) ; Mol Biol Rep. 2014 Aug;41(8):4865-79. (PMID: 24867080) ; Br J Psychiatry. 2011 Feb;198(2):93-8. (PMID: 21282779) ; Brain. 2008 May;131(Pt 5):1311-22. (PMID: 18390562) ; Nat Commun. 2013;4:1332. (PMID: 23299882) ; J Affect Disord. 2014 Oct;168:269-75. (PMID: 25069082) ; Arch Gen Psychiatry. 1961 Jun;4:561-71. (PMID: 13688369) ; Lancet. 2012 Feb 25;379(9817):721-8. (PMID: 22265699) ; Psychopharmacology (Berl). 2009 May;203(4):685-91. (PMID: 19031070) ; Neuropsychopharmacology. 2016 Jun;41(7):1803-12. (PMID: 26585287) ; Lancet. 2010 Jan 30;375(9712):385-95. (PMID: 20092882) ; Br J Psychiatry. 2009 Aug;195(2):102-8. (PMID: 19648538) ; Psychol Med. 2013 Jan;43(1):27-38. (PMID: 22617461) ; Cogn Emot. 2016 Nov;30(7):1247-59. (PMID: 26219310) ; Am J Psychiatry. 1976 Dec;133(12):1409-13. (PMID: 984241) ; Lancet Psychiatry. 2014 Oct;1(5):351-9. (PMID: 26360999) ; Psychopharmacology (Berl). 1980;71(2):173-9. (PMID: 6777817) ; Annu Rev Med. 1996;47:47-56. (PMID: 8712796) ; Lancet. 2015 Aug 1;386(9992):461-8. (PMID: 26003379) ; Psychol Med. 2015 Jan;45(2):375-80. (PMID: 25066689) ; BMJ. 2013 Jun 27;346:f3646. (PMID: 23814104) ; Neuropsychopharmacology. 1999 Apr;20(4):322-39. (PMID: 10088133) ; Biochem Soc Trans. 2009 Oct;37(Pt 5):1121-5. (PMID: 19754464) ; J Pers Soc Psychol. 1988 Jun;54(6):1063-70. (PMID: 3397865) ; Pharmacopsychiatry. 2001 Jul;34(4):132-6. (PMID: 11518473) Grant Information: MR/K022202/1 United Kingdom MRC_ Medical Research Council; MR/L013150/1 United Kingdom MRC_ Medical Research Council Contributed Indexing: Keywords: Ebselen; Emotional processing; Impulsivity; Lithium-mimetic* Substance Nomenclature: 0 (Azoles) ; 0 (Cyclooxygenase Inhibitors) ; 0 (Isoindoles) ; 0 (Neuroprotective Agents) ; 0 (Organoselenium Compounds) ; 40X2P7DPGH (ebselen) ; EC 3.1.3.2 (Phosphoric Monoester Hydrolases) ; EC 3.1.3.25 (myo-inositol-1 (or 4)-monophosphatase) Entry Date(s): Date Created: 20160604 Date Completed: 20171127 Latest Revision: 20211204 Update Code: 20231215 PubMed Central ID: PMC4917572

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Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.