Targeted chitosan-based bionanocomposites for controlled oral mucosal delivery of chlorhexidine.

Onnainty, R ; Onida, B ; et al.

In: International journal of pharmaceutics, Jg. 509 (2016-07-25), Heft 1-2, S. 408-418

academicJournal

The purpose of this study was to develop sustained release systems based on chitosan (CS) and montmorillonite (MMT) for chlorhexidine (CLX). Nanocomposites were prepared by ion-exchange. CLX systems were characterized by X-ray powder diffraction (XRD), thermal analysis (TGA), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray fluorescence analysis (XRF). The mucoadhesion properties of CLX nanocomposites were evaluated by SEM. The release behavior of these systems was also studied by the dialysis technique. The antibacterial activity was investigated in vitro by the disk diffusion test. Results showed long-term sustained release of CLX from the hybrid carriers without initial burst release. The release profiles of CLX from the carriers suggested the diffusion through a swollen matrix and water filled pores as the controlled drug release mechanism. The CLX hybrid nanosystem containing the positively-charged chitosan exhibited good mucoadhesion properties maintaining the CLX antimicrobial properties.

Titel:	Targeted chitosan-based bionanocomposites for controlled oral mucosal delivery of chlorhexidine.
Autor/in / Beteiligte Person:	Onnainty, R ; Onida, B ; Páez, P ; Longhi, M ; Barresi, A ; Granero, G
Zeitschrift:	International journal of pharmaceutics, Jg. 509 (2016-07-25), Heft 1-2, S. 408-418
Veröffentlichung:	Amsterdam, Elsevier/North-Holland Biomedical Press., 2016
Medientyp:	academicJournal
ISSN:	1873-3476 (electronic)
DOI:	10.1016/j.ijpharm.2016.06.011
Schlagwort:	Administration, Oral Bentonite chemistry Diffusion Drug Carriers chemistry Drug Delivery Systems methods Microscopy, Electron, Scanning methods Spectroscopy, Fourier Transform Infrared methods Thermogravimetry X-Ray Diffraction methods Biocompatible Materials chemistry Chitosan chemistry Chlorhexidine administration & dosage Chlorhexidine chemistry Delayed-Action Preparations chemistry Mouth Mucosa metabolism Nanocomposites chemistry
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Int J Pharm] 2016 Jul 25; Vol. 509 (1-2), pp. 408-418. <i>Date of Electronic Publication: </i>2016 Jun 07. MeSH Terms: Biocompatible Materials / chemistry ; Chitosan / chemistry ; Chlorhexidine / administration & dosage ; Chlorhexidine / chemistry ; Delayed-Action Preparations / chemistry ; Mouth Mucosa / metabolism ; Nanocomposites / *chemistry ; Administration, Oral ; Bentonite / chemistry ; Diffusion ; Drug Carriers / chemistry ; Drug Delivery Systems / methods ; Microscopy, Electron, Scanning / methods ; Spectroscopy, Fourier Transform Infrared / methods ; Thermogravimetry ; X-Ray Diffraction / methods Contributed Indexing: Keywords: Antibacterial activity; Chitosan; Chlorhexidine; Drug delivery systems; Mucoadhesion; Nanocomposites Substance Nomenclature: 0 (Biocompatible Materials) ; 0 (Delayed-Action Preparations) ; 0 (Drug Carriers) ; 1302-78-9 (Bentonite) ; 9012-76-4 (Chitosan) ; R4KO0DY52L (Chlorhexidine) Entry Date(s): Date Created: 20160611 Date Completed: 20170407 Latest Revision: 20170812 Update Code: 20240513

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