Just add water: cannabinoid discrimination in a water T-maze with FAAH(-/-) and FAAH(+/+) mice.
In: Behavioural pharmacology, Jg. 27 (2016-08-01), Heft 5, S. 479-84
academicJournal
Zugriff:
Incomplete overlap in the discriminative stimulus effects of Δ-tetrahydrocannabinol (THC) and the endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol has been reported in food-reinforced tasks. The aim of this study was to examine cannabinoid discriminative stimulus effects in a nonappetitive procedure. Adult male mice lacking the gene for AEA's major metabolic enzyme, fatty acid amide hydrolase (FAAH), and FAAH mice were trained to discriminate THC or AEA in a water T-maze, in which the response was swimming to an escape platform on the injection-appropriate side. JZL184, a monoacylglycerol lipase inhibitor, was also tested. FAAH mice showed faster acquisition than FAAH mice. THC and AEA fully substituted, with only minor cross-procedure potency variations. Incomplete substitution of JZL184 was observed in THC-trained FAAH mice in the water-maze task, as contrasted with full substitution in a food-reinforced nose-poke procedure. Stress-induced changes in AEA and/or 2-arachidonoylglycerol concentrations in the brain may have mediated this attenuation. JZL184 also partially substituted in AEA-trained FAAH mice in the water maze, suggesting incomplete overlap in the stimulus effects of AEA and JZL184. Through the use of a novel water-maze procedure, the present study supports the work of previous behavioral pharmacologists in showing the robustness of the discrimination paradigm.
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Just add water: cannabinoid discrimination in a water T-maze with FAAH(-/-) and FAAH(+/+) mice.
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Autor/in / Beteiligte Person: | Wiley, JL ; Lefever, TW ; Pulley, NS ; Marusich, JA ; Cravatt, BF ; Lichtman, AH |
Zeitschrift: | Behavioural pharmacology, Jg. 27 (2016-08-01), Heft 5, S. 479-84 |
Veröffentlichung: | London : Lippincott Williams and Wilkins ; <i>Original Publication</i>: London : Clinical Neuroscience Publishers,, 2016 |
Medientyp: | academicJournal |
ISSN: | 1473-5849 (electronic) |
DOI: | 10.1097/FBP.0000000000000228 |
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