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Hybrid nanoparticles with magnetic poly (lactide-co-glycolide) (PLGA) nanoparticle 'core', surface modified with folate-chitosan (fol-cht) conjugate 'shell' are evaluated as simultaneous anti-cancer therapeutic and MRI contrast agent. The fol-cht conjugate is prepared using carbodiimide crosslinking chemistry at an optimized folate to amine (chitosan) molar ratio for further coating on PLGA nanoparticles loaded with docetaxel and well packed super paramagnetic iron oxide nanoparticles (SPIONs). Apart from possessing a targeting moiety, the coating provides a physical barrier to avoid undesired burst release of drug and also imparts sensitivity to acidic pH, due to protonated amine group dependent decondensation of the coating and subsequent drug release. The biocompatible hybrid nanoparticles provide receptor targeted docetaxel and SPION delivery for anti-cancer therapy and magnetic resonance (MR) imaging respectively, as tested in both folate receptor positive and negative cancer cells. Enhancement in nanoparticle uptake by folate receptor positive oral cancer cells caused significant increase in docetaxel mediated cytotoxicity. While polymeric encapsulation and fol-cht coating negatively affects the magnetic property of iron oxide nanoparticles, their aggregation in the core, shortened the overall T 2 relaxation time thereby enhancing the nanoparticle relaxivity to provide better in vitro MR imaging.

Titel:	Magnetic core-shell hybrid nanoparticles for receptor targeted anti-cancer therapy and magnetic resonance imaging.
Autor/in / Beteiligte Person:	Shanavas, A ; Sasidharan, S ; Bahadur, D ; Srivastava, R
Zeitschrift:	Journal of colloid and interface science, Jg. 486 (2017-01-15), S. 112-120
Veröffentlichung:	Orlando, FL : Academic Press ; <i>Original Publication</i>: New York., 2017
Medientyp:	academicJournal
ISSN:	1095-7103 (electronic)
DOI:	10.1016/j.jcis.2016.09.060
Schlagwort:	Antineoplastic Agents chemistry Carbodiimides chemistry Cell Line, Tumor Chitosan chemistry Cross-Linking Reagents chemistry Docetaxel Drug Compounding Drug Liberation Epithelial Cells pathology Epithelial Cells ultrastructure Folate Receptor 1 genetics Folate Receptor 1 metabolism Folic Acid chemistry Gene Expression Humans Hydrogen-Ion Concentration Kinetics Lactic Acid metabolism Magnetic Resonance Imaging methods Magnetite Nanoparticles ultrastructure Polyglycolic Acid metabolism Polylactic Acid-Polyglycolic Acid Copolymer Taxoids chemistry Taxoids pharmacology Antineoplastic Agents pharmacology Contrast Media chemistry Epithelial Cells drug effects Ferric Compounds chemistry Lactic Acid chemistry Magnetite Nanoparticles chemistry Polyglycolic Acid chemistry
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Colloid Interface Sci] 2017 Jan 15; Vol. 486, pp. 112-120. <i>Date of Electronic Publication: </i>2016 Sep 28. MeSH Terms: Antineoplastic Agents / pharmacology ; Contrast Media / chemistry ; Epithelial Cells / drug effects ; Ferric Compounds / chemistry ; Lactic Acid / chemistry ; Magnetite Nanoparticles / chemistry ; Polyglycolic Acid / *chemistry ; Antineoplastic Agents / chemistry ; Carbodiimides / chemistry ; Cell Line, Tumor ; Chitosan / chemistry ; Cross-Linking Reagents / chemistry ; Docetaxel ; Drug Compounding ; Drug Liberation ; Epithelial Cells / pathology ; Epithelial Cells / ultrastructure ; Folate Receptor 1 / genetics ; Folate Receptor 1 / metabolism ; Folic Acid / chemistry ; Gene Expression ; Humans ; Hydrogen-Ion Concentration ; Kinetics ; Lactic Acid / metabolism ; Magnetic Resonance Imaging / methods ; Magnetite Nanoparticles / ultrastructure ; Polyglycolic Acid / metabolism ; Polylactic Acid-Polyglycolic Acid Copolymer ; Taxoids / chemistry ; Taxoids / pharmacology Contributed Indexing: Keywords: Core-shell; Folate-chitosan; MRI; Magnetic PLGA; Receptor targeting Substance Nomenclature: 0 (Antineoplastic Agents) ; 0 (Carbodiimides) ; 0 (Contrast Media) ; 0 (Cross-Linking Reagents) ; 0 (Ferric Compounds) ; 0 (Folate Receptor 1) ; 0 (Magnetite Nanoparticles) ; 0 (Taxoids) ; 15H5577CQD (Docetaxel) ; 1K09F3G675 (ferric oxide) ; 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer) ; 26009-03-0 (Polyglycolic Acid) ; 33X04XA5AT (Lactic Acid) ; 9012-76-4 (Chitosan) ; 935E97BOY8 (Folic Acid) Entry Date(s): Date Created: 20161005 Date Completed: 20170410 Latest Revision: 20181202 Update Code: 20231215

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Magnetic core-shell hybrid nanoparticles for receptor targeted anti-cancer therapy and magnetic resonance imaging.