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Accumulating evidence suggests that transcriptional regulation is required for maintenance of long-term memories (LTMs). Here we characterize global transcriptional and epigenetic changes that occur during LTM storage in the Drosophila mushroom bodies (MBs), structures important for memory. Although LTM formation requires the CREB transcription factor and its coactivator, CBP, subsequent early maintenance requires CREB and a different coactivator, CRTC. Late maintenance becomes CREB independent and instead requires the transcription factor Bx. Bx expression initially depends on CREB/CRTC activity, but later becomes CREB/CRTC independent. The timing of the CREB/CRTC early maintenance phase correlates with the time window for LTM extinction and we identify different subsets of CREB/CRTC target genes that are required for memory maintenance and extinction. Furthermore, we find that prolonging CREB/CRTC-dependent transcription extends the time window for LTM extinction. Our results demonstrate the dynamic nature of stored memory and its regulation by shifting transcription systems in the MBs.

Titel:	Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies.
Autor/in / Beteiligte Person:	Hirano, Y ; Ihara, K ; Masuda, T ; Yamamoto, T ; Iwata, I ; Takahashi, A ; Awata, H ; Nakamura, N ; Takakura, M ; Suzuki, Y ; Horiuchi, J ; Okuno, H ; Saitoe, M
Link:	Full Text Finder (Volltext)
Zeitschrift:	Nature communications, Jg. 7 (2016-11-14), S. 13471
Veröffentlichung:	[London] : Nature Pub. Group, 2016
Medientyp:	academicJournal
ISSN:	2041-1723 (electronic)
DOI:	10.1038/ncomms13471
Schlagwort:	Animals Animals, Genetically Modified Cyclic AMP Response Element-Binding Protein genetics Cyclic AMP Response Element-Binding Protein metabolism Drosophila Proteins genetics Drosophila Proteins metabolism Drosophila melanogaster metabolism Gene Expression Profiling methods Gene Ontology Neurons metabolism Transcription Factors genetics Transcription Factors metabolism Drosophila melanogaster genetics Gene Expression Regulation Memory, Long-Term Mushroom Bodies metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Nat Commun] 2016 Nov 14; Vol. 7, pp. 13471. <i>Date of Electronic Publication: </i>2016 Nov 14. MeSH Terms: Gene Expression Regulation* ; Memory, Long-Term* ; Drosophila melanogaster / genetics ; Mushroom Bodies / metabolism ; Animals ; Animals, Genetically Modified ; Cyclic AMP Response Element-Binding Protein / genetics ; Cyclic AMP Response Element-Binding Protein / metabolism ; Drosophila Proteins / genetics ; Drosophila Proteins / metabolism ; Drosophila melanogaster / metabolism ; Gene Expression Profiling / methods ; Gene Ontology ; Neurons / metabolism ; Transcription Factors / genetics ; Transcription Factors / metabolism References: Behav Brain Res. 2009 Dec 28;205(2):544-9. (PMID: 19703496) ; Learn Mem. 2013 Jan 15;20(2):61-74. (PMID: 23322554) ; Mol Cell Biol. 2005 Sep;25(18):8228-38. (PMID: 16135811) ; Neuron. 2015 Jun 17;86(6):1369-84. (PMID: 26087164) ; Neuron. 2002 Aug 15;35(4):605-23. (PMID: 12194863) ; Genetics. 2004 Nov;168(3):1385-93. (PMID: 15579692) ; J Neurosci. 2004 Oct 6;24(40):8823-8. (PMID: 15470148) ; Neuron. 2004 Jun 24;42(6):961-72. (PMID: 15207240) ; Mol Cell. 2000 Feb;5(2):367-75. (PMID: 10882077) ; PLoS One. 2011 Apr 11;6(4):e18412. (PMID: 21494552) ; Nature. 2009 May 7;459(7243):55-60. (PMID: 19424149) ; Oncogene. 1996 Apr 18;12(8):1827-31. (PMID: 8622904) ; Genes Dev. 2012 Mar 15;26(6):527-41. (PMID: 22426530) ; Cell. 1994 Oct 7;79(1):49-58. (PMID: 7923376) ; Mol Cell Biol. 1995 Sep;15(9):5123-30. (PMID: 7651429) ; Neuron. 2004 Jun 24;42(6):947-59. (PMID: 15207239) ; Science. 2013 Jan 25;339(6118):443-6. (PMID: 23349290) ; Neuron. 2013 Sep 4;79(5):945-56. (PMID: 24012007) ; J Neurosci. 2009 Jan 14;29(2):402-13. (PMID: 19144840) ; Nat Rev Mol Cell Biol. 2007 Dec;8(12):983-94. (PMID: 18037899) ; Cell. 2012 Apr 27;149(3):693-707. (PMID: 22541438) ; Mol Cell. 2016 Jan 21;61(2):183-4. (PMID: 26799762) ; J Biol Chem. 2004 Sep 24;279(39):40545-59. (PMID: 15273246) ; Cell. 2012 Jul 6;150(1):207-21. (PMID: 22770221) ; Curr Biol. 2002 Apr 30;12(9):762-6. (PMID: 12007422) ; Fly (Austin). 2008 Jul-Aug;2(4):236-9. (PMID: 18776741) ; Cell. 2014 Jan 16;156(1-2):261-76. (PMID: 24439381) ; Curr Opin Neurobiol. 2013 Feb;23(1):84-91. (PMID: 23084099) ; Nat Neurosci. 2016 Jan;19(1):102-10. (PMID: 26656643) ; Biometrics. 2011 Mar;67(1):151-63. (PMID: 20528864) ; J Comp Physiol A. 1985 Sep;157(2):263-77. (PMID: 3939242) ; Genetics. 2014 Dec;198(4):1571-86. (PMID: 25326235) ; Cell. 1994 Oct 7;79(1):35-47. (PMID: 7923375) ; Nat Struct Mol Biol. 2008 Apr;15(4):364-72. (PMID: 18327268) ; Elife. 2014 Dec 23;3:e04577. (PMID: 25535793) ; Neuropsychopharmacology. 2011 Jan;36(1):357-8. (PMID: 21116250) ; Genes Brain Behav. 2010 Mar 1;9(2):203-12. (PMID: 20015341) ; Annu Rev Psychol. 2004;55:51-86. (PMID: 14744210) ; Cell. 2001 Mar 9;104(5):675-86. (PMID: 11257222) ; Nat Rev Mol Cell Biol. 2011 Mar;12(3):141-51. (PMID: 21346730) ; Proc Natl Acad Sci U S A. 2013 May 21;110(21):8627-31. (PMID: 23641003) ; Neuron. 2011 Apr 14;70(1):8-19. (PMID: 21482352) ; Nature. 2002 Apr 25;416(6883):870-4. (PMID: 11976688) ; Trends Genet. 2014 Dec;30(12):529-39. (PMID: 25269450) ; Neuron. 2014 Oct 1;84(1):92-106. (PMID: 25277455) ; PLoS One. 2011 Feb 16;6(2):e16432. (PMID: 21358819) ; Bioinformatics. 2014 Jan 15;30(2):284-6. (PMID: 24227674) ; Neurobiol Learn Mem. 2011 Jul;96(1):2-12. (PMID: 21195202) ; Curr Opin Struct Biol. 2008 Dec;18(6):682-9. (PMID: 19056256) ; Science. 2010 May 7;328(5979):753-6. (PMID: 20448184) ; Nat Neurosci. 2010 Jun;13(6):664-6. (PMID: 20495557) ; Genes Dev. 2012 Oct 1;26(19):2119-37. (PMID: 23028141) ; J Physiol. 2013 Jan 1;591(1):287-302. (PMID: 23027817) ; Curr Opin Neurobiol. 2013 Jun;23(3):324-9. (PMID: 23391527) ; Learn Mem. 2005 Mar-Apr;12 (2):111-9. (PMID: 15805310) ; Mol Cell. 2009 Feb 13;33(3):312-22. (PMID: 19217405) ; Aging (Albany NY). 2012 Apr;4(4):247-55. (PMID: 22511639) ; Learn Mem. 2011 Jul 15;18(8):508-18. (PMID: 21764847) ; Nat Protoc. 2009;4(1):44-57. (PMID: 19131956) ; Dev Cell. 2010 Jun 15;18(6):1030-40. (PMID: 20627084) ; J Neurophysiol. 2008 Feb;99(2):734-46. (PMID: 18094099) ; BMC Genomics. 2014 Apr 15;15:284. (PMID: 24735413) ; Neuron. 2003 Dec 4;40(5):1003-11. (PMID: 14659098) ; Cell Metab. 2008 May;7(5):434-44. (PMID: 18460334) ; Nat Rev Neurosci. 2013 Feb;14(2):97-111. (PMID: 23324667) ; Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):198-203. (PMID: 14684832) ; Cell. 2014 Mar 27;157(1):163-86. (PMID: 24679534) ; Genome Biol. 2014;15(12):550. (PMID: 25516281) Substance Nomenclature: 0 (CRTC protein, Drosophila) ; 0 (Cyclic AMP Response Element-Binding Protein) ; 0 (Drosophila Proteins) ; 0 (Transcription Factors) Entry Date(s): Date Created: 20161115 Date Completed: 20180917 Latest Revision: 20181113 Update Code: 20231215 PubMed Central ID: PMC5114576

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Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies.