Independent tonotopy and thalamocortical projection patterns in two adjacent parts of the classical primary auditory cortex in mice.

Tsukano, H ; Horie, M ; et al.

In: Neuroscience letters, Jg. 637 (2017-01-10), S. 26-30

academicJournal

Amid recent amendment of delineation of a mouse auditory cortical map, a caudal auditory field, originally defined as the primary auditory cortex (AI), was divided into the AI and dorsomedial field (DM), based on distinct high frequency areas. A low frequency area was not previously established in the DM because responses to low frequency tones were weak in this area. This may lead to the misconception that the DM is an atypical region that lacks a low frequency band. In the current study, we confirmed that the DM has a low frequency area that is completely independent from the AI. First, we conducted flavoprotein fluorescence imaging with improved signal to noise ratio and revealed the presence of two separated low frequency areas in the AI and DM. Next, we injected a retrograde neural tracer along the tonotopic axis of the AI or DM to reveal the thalamic origins in the ventral division of the medial geniculate body (MGv). We found that neurons projecting to low frequency areas of the AI and DM occupied different locations within the MGv and mutually independent topographic organizations consisting of thalamic neurons projecting to the AI or DM. These results indicate that the AI and DM have distinct low frequency areas with distinct thalamic projections from the MGv. Our findings reaffirm that the AI and DM should be regarded as independent regions in the mouse auditory cortex.

Titel:	Independent tonotopy and thalamocortical projection patterns in two adjacent parts of the classical primary auditory cortex in mice.
Autor/in / Beteiligte Person:	Tsukano, H ; Horie, M ; Takahashi, K ; Hishida, R ; Takebayashi, H ; Shibuki, K
Zeitschrift:	Neuroscience letters, Jg. 637 (2017-01-10), S. 26-30
Veröffentlichung:	Limerick : Elsevier Scientific Publishers Ireland ; <i>Original Publication</i>: Amsterdam, Elsevier/North-Holland., 2017
Medientyp:	academicJournal
ISSN:	1872-7972 (electronic)
DOI:	10.1016/j.neulet.2016.11.062
Schlagwort:	Acoustic Stimulation methods Animals Image Processing, Computer-Assisted methods Male Mice, Inbred C57BL Auditory Cortex physiology Auditory Pathways physiology Geniculate Bodies physiology Neurons physiology Thalamus physiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Neurosci Lett] 2017 Jan 10; Vol. 637, pp. 26-30. <i>Date of Electronic Publication: </i>2016 Nov 30. MeSH Terms: Auditory Cortex / physiology ; Auditory Pathways / physiology ; Geniculate Bodies / physiology ; Neurons / physiology ; Thalamus / *physiology ; Acoustic Stimulation / methods ; Animals ; Image Processing, Computer-Assisted / methods ; Male ; Mice, Inbred C57BL Contributed Indexing: Keywords: Dorsomedial field; Medial geniculate body; Mice; Primary auditory cortex; Tonotopy; Topology Entry Date(s): Date Created: 20161205 Date Completed: 20171031 Latest Revision: 20171101 Update Code: 20231215

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