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Background: In-stent restenosis (ISR) is still a major concern in interventional cardiology. Drug coated balloon (DCB) angioplasty has been shown to be a promising option in treatment of ISR. However heterogeneity of different DCBs in suppression of neointimal growth has been described in a porcine model of coronary ISR. Therefore, in this registry analysis, we compared two frequently used paclitaxel eluting DCBs, the SeQuent Please and the Pantera Lux DCB.

Methods: 571 patients were treated with DCB angioplasty at the Heinrich-Heine University Düsseldorf between 2009 and 2012. Follow-up was conducted during ambulatory care at our department. Major adverse cardiac events (death, myocardial infarction [MI] and target lesion revascularization) were registered during hospitalization and follow-up.

Results: Patient characteristics, prior diseases, clinical presentation, ejection fraction, procedural success and lost-for-follow-up did not differ between patients treated with the SeQuent Please and. The Pantera Lux DCB. MACE during hospital course were similar as well (Pantera Lux: 6 patients [1.6%] vs. SeQuent®Please: 3 patients [1.5%], relative risk 1.06, 95% confidence interval 0.3-4.2, P=0.93). Event free survival was significantly longer in patients treated with the Pantera Lux DCB as compared to SeQuent Please DCB (Hazard ratio: 0.65, 95% confidence interval 0.43-0.98; P value of log-rank test: 0.0405).

Conclusion: MACE free survival was longer in Pantera Lux DCB treated patients as compared to SeQuent Please treated patients. This finding has to be confirmed in future clinical trials.

Titel:	SeQuent Please vs. Pantera Lux drug coated balloon angioplasty in real life: Results from the Düsseldorf DCB registry.
Autor/in / Beteiligte Person:	Assadi-Schmidt, A ; Mohring, A ; Liebsch, E ; Dannenberg, L ; Achilles, A ; Pöhl, M ; Afzal, S ; Veulemans, V ; Horn, P ; Sansone, R ; Bönner, F ; Levkau, B ; Kelm, M ; Zeus, T ; Polzin, A
Zeitschrift:	International journal of cardiology, Jg. 231 (2017-03-15), S. 68-72
Veröffentlichung:	Amsterdam : Elsevier ; <i>Original Publication</i>: Amsterdam : Elsevier/North-Holland Biomedical Press, c1981-, 2017
Medientyp:	academicJournal
ISSN:	1874-1754 (electronic)
DOI:	10.1016/j.ijcard.2016.12.022
Schlagwort:	Aged Antineoplastic Agents, Phytogenic pharmacology Cause of Death trends Coronary Restenosis epidemiology Female Germany epidemiology Humans Incidence Male Retrospective Studies Survival Rate trends Treatment Outcome Angioplasty, Balloon, Coronary methods Coated Materials, Biocompatible Coronary Artery Disease surgery Coronary Restenosis prevention & control Drug-Eluting Stents Paclitaxel pharmacology Registries
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Int J Cardiol] 2017 Mar 15; Vol. 231, pp. 68-72. <i>Date of Electronic Publication: </i>2016 Dec 13. MeSH Terms: Coated Materials, Biocompatible* ; Drug-Eluting Stents* ; Registries* ; Angioplasty, Balloon, Coronary / methods ; Coronary Artery Disease / surgery ; Coronary Restenosis / prevention & control ; Paclitaxel / pharmacology ; Aged ; Antineoplastic Agents, Phytogenic / pharmacology ; Cause of Death / trends ; Coronary Restenosis / epidemiology ; Female ; Germany / epidemiology ; Humans ; Incidence ; Male ; Retrospective Studies ; Survival Rate / trends ; Treatment Outcome Contributed Indexing: Keywords: Coronary intervention; Drug-coated balloon; Drug-eluting balloon; Paclitaxel; Registry Substance Nomenclature: 0 (Antineoplastic Agents, Phytogenic) ; 0 (Coated Materials, Biocompatible) ; P88XT4IS4D (Paclitaxel) Entry Date(s): Date Created: 20170117 Date Completed: 20171204 Latest Revision: 20171204 Update Code: 20231215

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SeQuent Please vs. Pantera Lux drug coated balloon angioplasty in real life: Results from the Düsseldorf DCB registry.