Effects of interleukin 2 and large envelope glycoprotein (gp 120) of human immunodeficiency virus (HIV) on lymphocyte proliferative responses to cytomegalovirus.

Krowka, J ; Stites, D ; et al.

In: Clinical and experimental immunology, Jg. 72 (1988-05-01), Heft 2, S. 179-85

Online academicJournal

Zugriff:

Volltext (PDF)

Lymphocytes from many HIV-infected asymptomatic individuals or patients with AIDS-related conditions (ARC) and from all AIDS patients were unable to proliferate in vitro in response to UV-inactivated cytomegalovirus (CMV). The addition of recombinant IL2 (rIL2) restored proliferative responses of lymphocytes from most HIV-infected asymptomatic individuals and ARC patients to levels similar to those of HIV-seronegative (HIV-) CMV-seropositive (CMV+) individuals. In contrast, rIL2 augmented CMV-specific lymphocyte proliferation of only 33% (6/18) of AIDS patients. Proliferative responses to CMV with or without rIL2 did not correlate well with the levels of CD4+ lymphocytes, HIV antigen levels or ratios of CD4+ and CD8+ lymphocytes. Proliferative responses to CMV were inhibited by relatively high concentrations (greater than or equal to 10 micrograms/ml) of recombinant HIV envelope glycoprotein (rgp120) and this immunosuppression was completely overcome by rIL2. These results indicate that defects in antigen-driven lymphocyte responses of HIV-infected individuals are not simply the result of reduced numbers of CD4+ lymphocytes but are influenced by defects in IL2 pathways and by immunosuppressive effects of HIV gp120.

Titel:	Effects of interleukin 2 and large envelope glycoprotein (gp 120) of human immunodeficiency virus (HIV) on lymphocyte proliferative responses to cytomegalovirus.
Autor/in / Beteiligte Person:	Krowka, J ; Stites, D ; Mills, J ; Hollander, H ; McHugh, T ; Busch, M ; Wilhelm, L ; Blackwood, L
Link:	Volltext (PDF)
Zeitschrift:	Clinical and experimental immunology, Jg. 72 (1988-05-01), Heft 2, S. 179-85
Veröffentlichung:	2022- : Oxford : Oxford University Press ; <i>Original Publication</i>: Oxford : Blackwell Scientific Publications, 1988
Medientyp:	academicJournal
ISSN:	0009-9104 (print)
Schlagwort:	Acquired Immunodeficiency Syndrome immunology Antigens, Viral analysis HIV metabolism HIV Envelope Protein gp120 Humans In Vitro Techniques Leukocyte Count Lymphocytes immunology Male Mitosis Cytomegalovirus immunology Interleukin-2 pharmacology Lymphocyte Activation drug effects Retroviridae Proteins pharmacology Viral Envelope Proteins pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Language: English [Clin Exp Immunol] 1988 May; Vol. 72 (2), pp. 179-85. MeSH Terms: Cytomegalovirus / immunology ; Interleukin-2 / pharmacology ; Lymphocyte Activation / drug effects ; Retroviridae Proteins / pharmacology ; Viral Envelope Proteins / *pharmacology ; Acquired Immunodeficiency Syndrome / immunology ; Antigens, Viral / analysis ; HIV / metabolism ; HIV Envelope Protein gp120 ; Humans ; In Vitro Techniques ; Leukocyte Count ; Lymphocytes / immunology ; Male ; Mitosis References: Nature. 1977 Jul 14;268(5616):154-6. (PMID: 145543) ; Cell Immunol. 1987 Nov;110(1):140-8. (PMID: 2824064) ; J Exp Med. 1982 Oct 1;156(4):1065-76. (PMID: 6984061) ; J Immunol. 1983 May;130(5):2372-8. (PMID: 6300245) ; Ann Intern Med. 1983 Aug;99(2):151-8. (PMID: 6309049) ; Ann Intern Med. 1983 Aug;99(2):208-20. (PMID: 6309051) ; Science. 1984 Jul 6;225(4657):59-63. (PMID: 6328660) ; J Clin Immunol. 1984 Jul;4(4):304-11. (PMID: 6086703) ; J Immunol. 1984 Sep;133(3):1093-100. (PMID: 6235279) ; J Clin Invest. 1985 May;75(5):1538-44. (PMID: 2581997) ; N Engl J Med. 1985 Jul 11;313(2):79-84. (PMID: 2582258) ; Clin Exp Immunol. 1985 Apr;60(1):25-30. (PMID: 3924451) ; Clin Exp Immunol. 1985 Apr;60(1):31-8. (PMID: 3159524) ; Clin Exp Immunol. 1985 Apr;60(1):8-16. (PMID: 3924452) ; Proc Natl Acad Sci U S A. 1985 Aug;82(16):5535-9. (PMID: 2991932) ; J Clin Immunol. 1985 Jul;5(4):239-45. (PMID: 3876352) ; J Infect Dis. 1985 Oct;152(4):727-33. (PMID: 2413136) ; Ann Intern Med. 1985 Nov;103(5):704-9. (PMID: 2996403) ; J Clin Microbiol. 1985 Dec;22(6):1014-9. (PMID: 2999186) ; N Engl J Med. 1985 Dec 12;313(24):1504-10. (PMID: 3934537) ; Clin Immunol Immunopathol. 1986 Feb;38(2):161-77. (PMID: 3510102) ; Proc Natl Acad Sci U S A. 1985 Dec;82(24):8691-5. (PMID: 3001715) ; J Immunol. 1986 Mar 1;136(5):1625-8. (PMID: 2419409) ; Lancet. 1986 Jul 26;2(8500):177-80. (PMID: 2873436) ; Science. 1986 Jul 11;233(4760):209-12. (PMID: 3014647) ; Cell Immunol. 1986 Mar;98(1):156-71. (PMID: 3017581) ; Lancet. 1986 Nov 29;2(8518):1233-6. (PMID: 2878129) ; J Immunol. 1987 Apr 15;138(8):2640-4. (PMID: 3031162) ; J Immunol. 1981 Nov;127(5):2124-9. (PMID: 6457863) Substance Nomenclature: 0 (Antigens, Viral) ; 0 (HIV Envelope Protein gp120) ; 0 (Interleukin-2) ; 0 (Retroviridae Proteins) ; 0 (Viral Envelope Proteins) Entry Date(s): Date Created: 19880501 Date Completed: 19881006 Latest Revision: 20181113 Update Code: 20240513 PubMed Central ID: PMC1541530

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.