Amplified CPEs enhancement of chorioamnion membrane mass transport by encapsulation in nano-sized PLGA particles.

Azagury, A ; Amar-Lewis, E ; et al.

In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Jg. 117 (2017-08-01), S. 292-299

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Chemical penetration enhancers (CPEs) have long been used for mass transport enhancement across membranes. Many CPEs are used in a solution or gel and could be a solvent. The use of CPEs is mainly limited due to their toxicity/irritation levels. This study presents the evaluation of encapsulated CPEs in nano-sized polymeric particles on the chorioamnion (CA) membrane mass transport. CPEs' mass encapsulated in nanoparticles was decreased by 10,000-fold. Interestingly, this approach resulted in a 6-fold increase in mass transport across the CA. This approach may also be used with other CPEs' base applications necessitating lower CPE concentration. Applying Ultrasound (US) has shown to increase the release rate of and also the mass transport across the CA membrane. It is proposed that encapsulated CPEs penetrate into the CA membrane thus prolonging their exposure, possibly extending their penetration into the CA membrane, while insonation also deepens their penetration into the CA membrane.

Titel:	Amplified CPEs enhancement of chorioamnion membrane mass transport by encapsulation in nano-sized PLGA particles.
Autor/in / Beteiligte Person:	Azagury, A ; Amar-Lewis, E ; Appel, R ; Hallak, M ; Kost, J
Zeitschrift:	European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Jg. 117 (2017-08-01), S. 292-299
Veröffentlichung:	Amsterdam : Elsevier Science ; <i>Original Publication</i>: Stuttgart : Wissenschaftliche Verlagsgesellschaft, c1991-, 2017
Medientyp:	academicJournal
ISSN:	1873-3441 (electronic)
DOI:	10.1016/j.ejpb.2017.04.031
Schlagwort:	Amnion drug effects Biological Transport drug effects Biological Transport physiology Chorion drug effects Drug Carriers administration & dosage Drug Carriers chemistry Female Humans Lactic Acid administration & dosage Lactic Acid chemistry Nanoparticles administration & dosage Nanoparticles chemistry Organ Culture Techniques Polyglycolic Acid administration & dosage Polyglycolic Acid chemistry Polylactic Acid-Polyglycolic Acid Copolymer Pregnancy Amnion metabolism Chorion metabolism Drug Carriers metabolism Drug Compounding methods Lactic Acid metabolism Nanoparticles metabolism Polyglycolic Acid metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Eur J Pharm Biopharm] 2017 Aug; Vol. 117, pp. 292-299. <i>Date of Electronic Publication: </i>2017 Apr 30. MeSH Terms: Amnion / metabolism ; Chorion / metabolism ; Drug Carriers / metabolism ; Drug Compounding / methods ; Lactic Acid / metabolism ; Nanoparticles / metabolism ; Polyglycolic Acid / *metabolism ; Amnion / drug effects ; Biological Transport / drug effects ; Biological Transport / physiology ; Chorion / drug effects ; Drug Carriers / administration & dosage ; Drug Carriers / chemistry ; Female ; Humans ; Lactic Acid / administration & dosage ; Lactic Acid / chemistry ; Nanoparticles / administration & dosage ; Nanoparticles / chemistry ; Organ Culture Techniques ; Polyglycolic Acid / administration & dosage ; Polyglycolic Acid / chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer ; Pregnancy Contributed Indexing: Keywords: Chemical penetration enhancers; Chorioamnion; Mass transport enhancement; Nanoparticles; PLGA; Ultrasound Substance Nomenclature: 0 (Drug Carriers) ; 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer) ; 26009-03-0 (Polyglycolic Acid) ; 33X04XA5AT (Lactic Acid) Entry Date(s): Date Created: 20170504 Date Completed: 20180405 Latest Revision: 20181202 Update Code: 20240513

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