Einzeltreffer — DigiBib

The whooping cough agent Bordetella pertussis controls the expression of its large virulence regulon in a coordinated manner through the two-component signal transduction system BvgAS. In addition to the genes coding for bona fide virulence factors, the Bvg regulon comprises genes of unknown function. In this work, we characterized a new Bvg-activated gene called BP2936. Homologs of BP2936 are found in other pathogenic Bordetellae and in several other species, including plant pathogens and environmental bacteria. We showed that the gene product of BP2936 is a membrane-associated methyl-transferase of free fatty acids. We thus propose to name it FmtB, for fatty acid methyl-transferase of Bordetella. The role of this protein was tested in cellular and animal models of infection, but the loss of BP2936 did not appear to affect host-pathogen interactions in those assays. The high level of conservation of BP2936 among B. pertussis isolates nevertheless argues that it probably plays a role in the life cycle of this pathogen.

Titel:	Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis.
Autor/in / Beteiligte Person:	Rivera-Millot, A ; Lesne, E ; Solans, L ; Coutte, L ; Bertrand-Michel, J ; Froguel, P ; Dhennin, V ; Hot, D ; Locht, C ; Antoine, R ; Jacob-Dubuisson, F
Link:	Volltext (PDF)
Zeitschrift:	PloS one, Jg. 12 (2017-05-11), Heft 5, S. e0176396
Veröffentlichung:	San Francisco, CA : Public Library of Science, 2017
Medientyp:	academicJournal
ISSN:	1932-6203 (electronic)
DOI:	10.1371/journal.pone.0176396
Schlagwort:	Bacterial Proteins genetics Bordetella pertussis enzymology Bordetella pertussis pathogenicity Fatty Acids, Nonesterified genetics Gene Expression Regulation, Bacterial Host-Pathogen Interactions genetics Humans Regulon genetics Signal Transduction Whooping Cough microbiology Bordetella pertussis genetics Methyltransferases genetics Virulence Factors, Bordetella genetics Whooping Cough genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [PLoS One] 2017 May 11; Vol. 12 (5), pp. e0176396. <i>Date of Electronic Publication: </i>2017 May 11 (<i>Print Publication: </i>2017). MeSH Terms: Bordetella pertussis / genetics ; Methyltransferases / genetics ; Virulence Factors, Bordetella / genetics ; Whooping Cough / genetics ; Bacterial Proteins / genetics ; Bordetella pertussis / enzymology ; Bordetella pertussis / pathogenicity ; Fatty Acids, Nonesterified / genetics ; Gene Expression Regulation, Bacterial ; Host-Pathogen Interactions / genetics ; Humans ; Regulon / genetics ; Signal Transduction ; Whooping Cough / microbiology References: Sci Rep. 2016 Sep 13;6:32774. (PMID: 27620673) ; Can J Biochem Physiol. 1959 Aug;37(8):911-7. (PMID: 13671378) ; Infect Immun. 2006 Oct;74(10):5537-48. (PMID: 16988229) ; J Biochem Mol Toxicol. 2006;20(6):302-8. (PMID: 17163484) ; J Biotechnol. 1999 Oct 8;75(2-3):147-59. (PMID: 10553654) ; J Exp Med. 2003 Mar 17;197(6):735-42. (PMID: 12629063) ; J Biol Chem. 2003 Sep 12;278(37):35826-36. (PMID: 12842883) ; Adv Microb Physiol. 2001;44:141-81. (PMID: 11407112) ; Methods Enzymol. 1994;235:458-65. (PMID: 8057916) ; Science. 2010 Nov 12;330(6006):982-5. (PMID: 21071671) ; Nat Rev Microbiol. 2014 Apr;12(4):274-88. (PMID: 24608338) ; Nucleic Acids Res. 2008 Apr;36(7):2295-300. (PMID: 18287115) ; Nature. 2010 Mar 11;464(7286):250-5. (PMID: 20164839) ; Eur J Biochem. 1973 Apr;34(2):333-44. (PMID: 4351160) ; Curr Opin Microbiol. 2001 Feb;4(1):82-9. (PMID: 11173039) ; Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7259-64. (PMID: 21422281) ; Infect Immun. 1994 Mar;62(3):769-78. (PMID: 8112848) ; J Bacteriol. 2006 Mar;188(5):1775-85. (PMID: 16484188) ; Infect Immun. 2010 Mar;78(3):907-13. (PMID: 20065021) ; J Bacteriol. 2004 Mar;186(5):1484-92. (PMID: 14973121) ; Infect Immun. 1990 Jun;58(6):1518-26. (PMID: 2341166) ; Infect Immun. 1993 Mar;61(3):807-15. (PMID: 8432601) ; BMC Struct Biol. 2005 Oct 14;5:19. (PMID: 16225687) ; Arch Biochem Biophys. 2015 Oct 1;583:140-9. (PMID: 26255776) ; FEMS Microbiol Rev. 2011 May;35(3):441-74. (PMID: 21204863) ; Mol Microbiol. 2001 May;40(3):669-83. (PMID: 11359572) ; J Bacteriol. 2011 Jul;193(14):3473-81. (PMID: 21602340) ; J Infect Dis. 1990 Jan;161(1):138-42. (PMID: 2295846) ; Nat Rev Microbiol. 2004 May;2(5):379-90. (PMID: 15100691) ; J Struct Biol. 2016 Mar;193(3):172-180. (PMID: 26772148) ; J Microbiol Methods. 2012 Aug;90(2):119-33. (PMID: 22537821) ; Microb Pathog. 2003 Jul;35(1):19-29. (PMID: 12860455) ; Trends Microbiol. 2003 Aug;11(8):367-73. (PMID: 12915094) ; PLoS One. 2009 Sep 14;4(9):e6996. (PMID: 19750014) ; EMBO J. 1992 Sep;11(9):3175-83. (PMID: 1354611) ; Gene. 1995 Dec 1;166(1):175-6. (PMID: 8529885) ; Nat Genet. 2003 Sep;35(1):32-40. (PMID: 12910271) ; J Bacteriol. 1982 Aug;151(2):996-1005. (PMID: 6284719) ; J Proteomics. 2016 Mar 16;136:55-67. (PMID: 26873878) ; Expert Rev Vaccines. 2012 Nov;11(11):1331-46. (PMID: 23249233) ; Appl Environ Microbiol. 1991 Apr;57(4):1202-6. (PMID: 2059041) ; J Struct Biol. 2011 Dec;176(3):409-13. (PMID: 21872662) ; PLoS Pathog. 2005 Dec;1(4):e45. (PMID: 16389302) ; J Biotechnol. 1996 Feb 28;45(2):137-48. (PMID: 9147447) ; Infect Immun. 2001 Oct;69(10):6038-43. (PMID: 11553541) ; Curr Protoc Bioinformatics. 2014 Sep 08;47:5.6.1-32. (PMID: 25199792) ; Mol Microbiol. 2015 Jan;95(2):313-31. (PMID: 25403021) ; Toxicology. 2005 Jun 1;210(2-3):197-204. (PMID: 15840433) ; EMBO J. 1996 Mar 1;15(5):1028-36. (PMID: 8605872) Substance Nomenclature: 0 (Bacterial Proteins) ; 0 (BvgB protein, Bordetella pertussis) ; 0 (Fatty Acids, Nonesterified) ; 0 (Virulence Factors, Bordetella) ; EC 2.1.1.- (Methyltransferases) ; EC 2.1.1.15 (fatty acid methyltransferase) Entry Date(s): Date Created: 20170512 Date Completed: 20170911 Latest Revision: 20240326 Update Code: 20240326 PubMed Central ID: PMC5426589

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Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis.