Einzeltreffer — DigiBib

Background: Genes and the environment contribute to variation in adult body mass index [BMI (in kg/m 2 )], but factors modifying these variance components are poorly understood. Objective: We analyzed genetic and environmental variation in BMI between men and women from young adulthood to old age from the 1940s to the 2000s and between cultural-geographic regions representing high (North America and Australia), moderate (Europe), and low (East Asia) prevalence of obesity. Design: We used genetic structural equation modeling to analyze BMI in twins ≥20 y of age from 40 cohorts representing 20 countries (140,379 complete twin pairs). Results: The heritability of BMI decreased from 0.77 (95% CI: 0.77, 0.78) and 0.75 (95% CI: 0.74, 0.75) in men and women 20-29 y of age to 0.57 (95% CI: 0.54, 0.60) and 0.59 (95% CI: 0.53, 0.65) in men 70-79 y of age and women 80 y of age, respectively. The relative influence of unique environmental factors correspondingly increased. Differences in the sets of genes affecting BMI in men and women increased from 20-29 to 60-69 y of age. Mean BMI and variances in BMI increased from the 1940s to the 2000s and were greatest in North America and Australia, followed by Europe and East Asia. However, heritability estimates were largely similar over measurement years and between regions. There was no evidence of environmental factors shared by co-twins affecting BMI. Conclusions: The heritability of BMI decreased and differences in the sets of genes affecting BMI in men and women increased from young adulthood to old age. The heritability of BMI was largely similar between cultural-geographic regions and measurement years, despite large differences in mean BMI and variances in BMI. Our results show a strong influence of genetic factors on BMI, especially in early adulthood, regardless of the obesity level in the population.

Titel:	Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts.
Autor/in / Beteiligte Person:	Silventoinen, K ; Jelenkovic, A ; Sund, R ; Yokoyama, Y ; Hur, YM ; Cozen, W ; Hwang, AE ; Mack, TM ; Honda, C ; Inui, F ; Iwatani, Y ; Watanabe, M ; Tomizawa, R ; Pietiläinen, KH ; Rissanen, A ; Siribaddana, SH ; Hotopf, M ; Sumathipala, A ; Rijsdijk, F ; Tan, Q ; Zhang, D ; Pang, Z ; Piirtola, M ; Aaltonen, S ; Öncel, SY ; Aliev, F ; Rebato, E ; Hjelmborg, JB ; Christensen, K ; Skytthe, A ; Kyvik, KO ; Silberg, JL ; Eaves, LJ ; Cutler, TL ; Ordoñana, JR ; Sánchez-Romera, JF ; Colodro-Conde, L ; Song, YM ; Yang, S ; Lee, K ; Franz, CE ; Kremen, WS ; Lyons, MJ ; Busjahn, A ; Nelson, TL ; Whitfield, KE ; Kandler, C ; Jang, KL ; Gatz, M ; Butler, DA ; Stazi, MA ; Fagnani, C ; D'Ippolito, C ; Duncan, GE ; Buchwald, D ; Martin, NG ; Medland, SE ; Montgomery, GW ; Jeong, HU ; Swan, GE ; Krasnow, R ; Magnusson, PK ; Pedersen, NL ; Dahl Aslan, AK ; McAdams, TA ; Eley, TC ; Gregory, AM ; Tynelius, P ; Baker, LA ; Tuvblad, C ; Bayasgalan, G ; Narandalai, D ; Spector, TD ; Mangino, M ; Lachance, G ; Burt, SA ; Klump, KL ; Harris, JR ; Brandt, I ; Nilsen, TS ; Krueger, RF ; McGue, M ; Pahlen, S ; Corley, RP ; Huibregtse, BM ; Bartels, M ; van Beijsterveldt CE ; Willemsen, G ; Goldberg, JH ; Rasmussen, F ; Tarnoki, AD ; Tarnoki, DL ; Derom, CA ; Vlietinck, RF ; Loos, RJ ; Hopper, JL ; Sung, J ; Maes, HH ; Turkheimer, E ; Boomsma, DI ; Sørensen, TI ; Kaprio, J
Link:	Full Text Finder (Volltext)
Zeitschrift:	The American journal of clinical nutrition, Jg. 106 (2017-08-01), Heft 2, S. 457-466
Veröffentlichung:	2023- : [New York, NY] : Elsevier ; <i>Original Publication</i>: Bethesda, MD : American Society of Clinical Nutrition, 2017
Medientyp:	academicJournal
ISSN:	1938-3207 (electronic)
DOI:	10.3945/ajcn.117.153643
Schlagwort:	Adult Age Factors Aged Aged, 80 and over Australia Culture Europe Female Humans Male Middle Aged North America Prevalence Sex Factors Twins, Dizygotic genetics Twins, Monozygotic genetics Young Adult Body Mass Index Body Weight genetics Environment Gene-Environment Interaction Obesity genetics Quantitative Trait, Heritable
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Twin Study Language: English [Am J Clin Nutr] 2017 Aug; Vol. 106 (2), pp. 457-466. <i>Date of Electronic Publication: </i>2017 Jul 05. MeSH Terms: Body Mass Index* ; Environment* ; Gene-Environment Interaction* ; Quantitative Trait, Heritable* ; Body Weight / genetics ; Obesity / genetics ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Australia ; Culture ; Europe ; Female ; Humans ; Male ; Middle Aged ; North America ; Prevalence ; Sex Factors ; Twins, Dizygotic / genetics ; Twins, Monozygotic / genetics ; Young Adult References: Front Endocrinol (Lausanne). 2012 Feb 28;3:29. (PMID: 22645519) ; PLoS One. 2011;6(6):e20816. (PMID: 21738588) ; Obes Rev. 2010 Dec;11(12):835-46. (PMID: 20973911) ; Obesity (Silver Spring). 2013 Sep;21(9):1923-34. (PMID: 23408493) ; Am J Clin Nutr. 2004 Aug;80(2):475-82. (PMID: 15277173) ; Front Genet. 2012 Jul 18;3:125. (PMID: 23056005) ; Obes Facts. 2009;2(3):196-202. (PMID: 20054225) ; Twin Res Hum Genet. 2015 Oct;18(5):557-70. (PMID: 26337138) ; Twin Res Hum Genet. 2015 Aug;18(4):348-60. (PMID: 26014041) ; Int J Obes (Lond). 2014 Aug;38(8):1133-41. (PMID: 24193660) ; Nat Genet. 2015 Nov;47(11):1357-62. (PMID: 26366552) ; PLoS Genet. 2015 Oct 01;11(10):e1005378. (PMID: 26426971) ; Twin Res. 2003 Oct;6(5):409-21. (PMID: 14624725) ; Am J Hum Genet. 2015 Nov 5;97(5):708-14. (PMID: 26544805) ; Behav Genet. 1997 Jul;27(4):325-51. (PMID: 9519560) ; Am J Clin Nutr. 2016 Aug;104(2):371-9. (PMID: 27413137) ; Psychometrika. 2016 Jun;81(2):535-49. (PMID: 25622929) ; Obesity (Silver Spring). 2008 Dec;16(12):2723-9. (PMID: 18927547) ; Genetics. 2016 Apr;202(4):1313-28. (PMID: 26868768) ; Twin Res. 2003 Oct;6(5):361-76. (PMID: 14624720) ; Obes Rev. 2013 Nov;14(11):871-82. (PMID: 23980914) ; Int J Obes (Lond). 2016 Sep;40(9):1376-83. (PMID: 27168050) ; Nature. 2015 Feb 12;518(7538):197-206. (PMID: 25673413) ; Lancet. 2016 Apr 2;387(10026):1377-1396. (PMID: 27115820) ; PLoS One. 2011;6(11):e27135. (PMID: 22087252) Grant Information: T32 DA017637 United States DA NIDA NIH HHS; G120/635 United Kingdom MRC_ Medical Research Council; R01 AG018384 United States AG NIA NIH HHS; P30 DK020541 United States DK NIDDK NIH HHS; P30 AG017265 United States AG NIA NIH HHS; R01 AG022381 United States AG NIA NIH HHS Contributed Indexing: Keywords: BMI; adults; genetics; international comparisons; twins Entry Date(s): Date Created: 20170707 Date Completed: 20170816 Latest Revision: 20230214 Update Code: 20231215 PubMed Central ID: PMC5525120

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts.