Mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes as potential antiproliferative agents.

Sutradhar, M ; Rajeshwari ; et al.

In: Journal of inorganic biochemistry, Jg. 175 (2017-10-01), S. 267-275

academicJournal

A series of four mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes [CuL(X)] 2 [L refers to the dianionic form of (5-bromo-2-hydroxybenzylidene)-2-hydroxybenzohydrazide; X=pyrazine (Pz; 1), pyridine (Py; 2), imidazole (Imz; 3) and 3-pyridinecarbonitrile (3-PyCN; 4)] has been synthesized and characterized by elemental analysis, various spectroscopic techniques and X-ray crystallography (for 1, 2 and 4). The antiproliferative effect of complexes 1-4 was examined in 4 human tumor cell lines (ovarian carcinoma (A2780), colorectal carcinoma (HCT116), lung adenocarcinoma (A549) and breast adenocarcinoma (MCF7)) and in normal human primary Fibroblasts. Complex 4 exhibits a high cytotoxic activity against ovarian and colorectal carcinoma cells (A2780, HCT116 respectively), with IC 50 much lower than those for normal primary fibroblasts. Complex 4 could induce cell death via apoptosis but not autophagy in colorectal carcinoma cells.

Titel:	Mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes as potential antiproliferative agents.
Autor/in / Beteiligte Person:	Sutradhar, M ; Rajeshwari ; Roy Barman, T ; Fernandes, AR ; Paradinha, F ; Roma-Rodrigues, C ; Guedes da Silva, MFC ; Pombeiro, AJL
Zeitschrift:	Journal of inorganic biochemistry, Jg. 175 (2017-10-01), S. 267-275
Veröffentlichung:	New York, Elsevier., 2017
Medientyp:	academicJournal
ISSN:	1873-3344 (electronic)
DOI:	10.1016/j.jinorgbio.2017.07.034
Schlagwort:	A549 Cells Heterocyclic Compounds chemistry Heterocyclic Compounds pharmacology Humans Hydrazones chemistry Hydrazones pharmacology Neoplasms metabolism Neoplasms pathology Antineoplastic Agents chemical synthesis Antineoplastic Agents chemistry Antineoplastic Agents pharmacology Cell Proliferation drug effects Coordination Complexes chemical synthesis Coordination Complexes chemistry Coordination Complexes pharmacology Copper chemistry Copper pharmacology Neoplasms drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [J Inorg Biochem] 2017 Oct; Vol. 175, pp. 267-275. <i>Date of Electronic Publication: </i>2017 Aug 02. MeSH Terms: Antineoplastic Agents* / chemical synthesis ; Antineoplastic Agents* / chemistry ; Antineoplastic Agents* / pharmacology ; Coordination Complexes* / chemical synthesis ; Coordination Complexes* / chemistry ; Coordination Complexes* / pharmacology ; Copper* / chemistry ; Copper* / pharmacology ; Cell Proliferation / drug effects ; Neoplasms / drug therapy ; A549 Cells ; Heterocyclic Compounds / chemistry ; Heterocyclic Compounds / pharmacology ; Humans ; Hydrazones / chemistry ; Hydrazones / pharmacology ; Neoplasms / metabolism ; Neoplasms / pathology Contributed Indexing: Keywords: Antiproliferative agent; Aroylhydrazone ligand; Human tumor cell lines; Mixed ligand copper(II) complexes; X-ray structure Substance Nomenclature: 0 (Antineoplastic Agents) ; 0 (Coordination Complexes) ; 0 (Heterocyclic Compounds) ; 0 (Hydrazones) ; 789U1901C5 (Copper) Entry Date(s): Date Created: 20170815 Date Completed: 20180102 Latest Revision: 20180313 Update Code: 20240513

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