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Gastric cancer is reported as one of the leading factors resulting in tumor-related death worldwide. However, the therapies to suppress gastric cancer are still limited and the emergence of drug resistance makes it necessary to develop new and effective anticancer drugs and combinational chemotherapy schemes. Liquiritin (LIQ) is a major constituent of Glycyrrhiza Radix, exhibiting various pharmacological activities, including anticancer. In this study, we investigated the role of LIQ in human gastric cancer cells with cisplatin (DDP) resistance. The findings suggested that LIQ, when applied in single therapy, could moderately inhibit the proliferation and migration of DDP-resistant gastric cancer cells, SGC7901/DDP. DDP and LIQ in combination induced G0/G1 cell cycle arrest to suppress the proliferation of gastric cancer cells, which were associated with the decrease of cyclin D1, cyclin A and cyclin-dependent kinase 4 (CDK4) and increase of p53 and p21. In addition, LIQ combined with DDP significantly induce apoptosis and autophagy both in vitro and in vivo through enhancing cleavage of caspase-8/-9/-3 and PARP, as well as LC3B and Beclin 1 expression. Significantly, the two drugs, when used in combination, prevented gastric cancer cell xenografts in nude mice in vivo. Together, the results revealed that application of DDP and LIQ in combination possessed a potential value against the growth of human gastric cancer with DDP resistance.

Titel:	Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo.
Autor/in / Beteiligte Person:	Wei, F ; Jiang, X ; Gao, HY ; Gao, SH
Zeitschrift:	International journal of oncology, Jg. 51 (2017-11-01), Heft 5, S. 1383-1394
Veröffentlichung:	<2003->: Athens, Greece : D.A. Spandidos ; <i>Original Publication</i>: Athens, Greece : Lychnia,, 2017
Medientyp:	academicJournal
ISSN:	1791-2423 (electronic)
DOI:	10.3892/ijo.2017.4134
Schlagwort:	Animals Apoptosis drug effects Autophagy drug effects Cell Line, Tumor Cell Proliferation drug effects Cisplatin adverse effects Drug Resistance, Neoplasm drug effects Glycyrrhiza chemistry Humans Mice Plant Extracts chemistry Stomach Neoplasms genetics Stomach Neoplasms pathology Xenograft Model Antitumor Assays Drug Resistance, Neoplasm genetics Flavanones administration & dosage Glucosides administration & dosage Plant Extracts administration & dosage Stomach Neoplasms drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Int J Oncol] 2017 Nov; Vol. 51 (5), pp. 1383-1394. <i>Date of Electronic Publication: </i>2017 Sep 22. MeSH Terms: Drug Resistance, Neoplasm / genetics ; Flavanones / administration & dosage ; Glucosides / administration & dosage ; Plant Extracts / administration & dosage ; Stomach Neoplasms / *drug therapy ; Animals ; Apoptosis / drug effects ; Autophagy / drug effects ; Cell Line, Tumor ; Cell Proliferation / drug effects ; Cisplatin / adverse effects ; Drug Resistance, Neoplasm / drug effects ; Glycyrrhiza / chemistry ; Humans ; Mice ; Plant Extracts / chemistry ; Stomach Neoplasms / genetics ; Stomach Neoplasms / pathology ; Xenograft Model Antitumor Assays References: World J Gastroenterol. 2010 Jul 21;16(27):3385-93. (PMID: 20632440) ; J Biol Chem. 2001 Jul 20;276(29):27058-63. (PMID: 11359776) ; Asian Pac J Cancer Prev. 2011;12(9):2263-9. (PMID: 22296367) ; Autophagy. 2008 Feb;4(2):151-75. (PMID: 18188003) ; Cancer Res. 2003 Mar 15;63(6):1311-6. (PMID: 12649192) ; Ann Oncol. 2009 Apr;20(4):666-73. (PMID: 19153121) ; Mol Cancer Ther. 2014 Jun;13(6):1589-98. (PMID: 24705351) ; CA Cancer J Clin. 2015 Mar;65(2):87-108. (PMID: 25651787) ; J Agric Food Chem. 2001 Mar;49(3):1546-51. (PMID: 11312894) ; J Clin Oncol. 2004 Mar 15;22(6):1007-13. (PMID: 14981105) ; Nat Rev Cancer. 2010 Aug;10(8):561-74. (PMID: 20651737) ; Cancer Lett. 2002 Nov 28;185(2):211-8. (PMID: 12169395) ; Oncol Rep. 2008 Dec;20(6):1545-51. (PMID: 19020740) ; Cell Motil Cytoskeleton. 2004 Dec;59(4):227-41. (PMID: 15476260) ; Int J Cancer. 2010 Aug 15;127(4):873-80. (PMID: 20013803) ; Int Immunopharmacol. 2009 May;9(5):632-8. (PMID: 19264152) ; Int J Oncol. 2003 Oct;23(4):1143-9. (PMID: 12963997) ; N Engl J Med. 2007 Nov 1;357(18):1810-20. (PMID: 17978289) ; Cancer Lett. 2012 Feb 28;315(2):198-205. (PMID: 22104727) ; Mol Pharm. 2009 May-Jun;6(3):928-39. (PMID: 19278222) ; Biochim Biophys Acta. 2002 Oct 2;1603(1):31-46. (PMID: 12242109) ; Biochem Biophys Res Commun. 2018 Mar 18;497(4):1177-1183. (PMID: 27914809) ; Mol Med Rep. 2016 Jan;13(1):572-8. (PMID: 26573417) ; Cancer Cell. 2010 Oct 19;18(4):329-40. (PMID: 20951943) ; Cancer Biol Ther. 2011 Jan 15;11(2):169-76. (PMID: 21263212) ; Mol Cell Biol. 2009 Aug;29(15):4188-200. (PMID: 19487459) ; Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18880-5. (PMID: 20956295) ; Asian Pac J Cancer Prev. 2011;12(2):525-30. (PMID: 21545224) ; Mol Cancer. 2007 Apr 02;6:24. (PMID: 17407548) ; Food Chem Toxicol. 2007 Dec;45(12):2470-8. (PMID: 17664038) ; J Clin Oncol. 2005 Dec 20;23(36):9408-21. (PMID: 16361640) ; J Clin Oncol. 2006 May 10;24(14):2137-50. (PMID: 16682732) ; Oncogene. 2007 Feb 26;26(9):1306-16. (PMID: 17322916) ; Oncol Rep. 2014 Jan;31(1):298-304. (PMID: 24247527) ; Drug Resist Updat. 2010 Jun;13(3):79-86. (PMID: 20471904) ; Autophagy. 2007 Nov-Dec;3(6):542-5. (PMID: 17611390) ; Cell Biochem Biophys. 2011 Jul;60(3):311-22. (PMID: 21274754) ; Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15077-82. (PMID: 14657337) ; Biochem Biophys Res Commun. 2015 Jul 3;462(3):227-32. (PMID: 25956062) ; Anticancer Res. 2005 Mar-Apr;25(2A):1147-55. (PMID: 15868958) ; Oncol Rep. 2013 Dec;30(6):2804-10. (PMID: 24085108) ; Asian Pac J Cancer Prev. 2012;13(7):3275-9. (PMID: 22994747) ; Biomed Pharmacother. 2011 Aug;65(5):354-8. (PMID: 21775093) ; Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1179-84. (PMID: 18289754) ; Cancer Lett. 2008 Dec 8;272(1):102-9. (PMID: 18703276) ; J Oral Pathol Med. 2012 Jan;41(1):40-6. (PMID: 21883486) ; Mol Med Rep. 2016 May;13(5):4065-72. (PMID: 26986492) ; J Clin Oncol. 2006 Nov 1;24(31):4991-7. (PMID: 17075117) ; Int J Hematol. 2010 Jul;92(1):136-43. (PMID: 20559758) ; Mutat Res. 2007 Jan-Feb;635(1):17-52. (PMID: 17157055) ; Chem Biol Interact. 2006 Jun 10;161(2):125-38. (PMID: 16647697) ; Biochim Biophys Acta. 2012 Oct;1823(10):1767-77. (PMID: 22732297) ; Mol Cell. 2013 Feb 7;49(3):399-410. (PMID: 23395270) ; Biotechnol Bioprocess Eng. 2008;13(6):671-676. (PMID: 32218675) Substance Nomenclature: 0 (Flavanones) ; 0 (Glucosides) ; 0 (Plant Extracts) ; Q20Q21Q62J (Cisplatin) ; T0O79T74CD (liquiritin) Entry Date(s): Date Created: 20171020 Date Completed: 20180723 Latest Revision: 20240327 Update Code: 20240327 PubMed Central ID: PMC5642394

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Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo.