Optical Coherence Tomography in Optic Nerve Hypoplasia: Correlation With Optic Disc Diameter, Nerve Fiber Layer Thickness, and Visual Function.
In: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, Jg. 38 (2018-09-01), Heft 3, S. 312-319
Online
academicJournal
Zugriff:
Background: The correlation between optic disc diameters (DDs) with average retinal nerve fiber layer thickness (RNFLT) and visual function in children with optic nerve hypoplasia (ONH) having nystagmus is unknown.
Methods: Data were obtained from a retrospective review of 28 children (mean age: 9.4 years; ±5.1). Optic DD was defined as the maximal horizontal opening of Bruch membrane with spectral optical coherence tomography combined with a confocal laser ophthalmoscope. Average RNFLT was obtained from circumpapillary b-scans. RNFLT was also remeasured at eccentricities that were proportionate with DD to rule out potential sampling artifacts. Visual function was assessed by visual acuity at last follow-up and by visual evoked potentials (VEP) in 11 patients. The eye with the larger DD, which had better visual acuity, was analyzed to exclude potential effects of amblyopia.
Results: DD was correlated with average RNFLT (r = 0.61), visual acuity (r = 0.32), and VEPs (r = 0.66). The relationship between RNFLT and DD was as follows: average RNFLT (μm) = 0.074 * DD (μm) - 18.8. RNFLT also correlated with the ratio of horizontal optic DD to macula-disc-margin distance (DD:DM; r = 0.59). RNFLT measured at eccentricities proportionate with DD showed progressive decrease in thickness only for DDs <1,100 μm. All patients with DD <1,000 μm had subnormal visual acuity, whereas those with DD <1,200 μm had subnormal VEPs.
Conclusions: DD correlates with average RNFLT and with visual function in children with ONH. Using OCT imaging, DD can be obtained in children with nystagmus and provides objective information.
Titel: |
Optical Coherence Tomography in Optic Nerve Hypoplasia: Correlation With Optic Disc Diameter, Nerve Fiber Layer Thickness, and Visual Function.
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Autor/in / Beteiligte Person: | Kelly, JP ; Baran, F ; Phillips, JO ; Weiss, AH |
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Zeitschrift: | Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, Jg. 38 (2018-09-01), Heft 3, S. 312-319 |
Veröffentlichung: | <1999->: Hagerstown, MD : Lippincott Williams & Wilkins ; <i>Original Publication</i>: New York, NY : Raven Press, c1994-, 2018 |
Medientyp: | academicJournal |
ISSN: | 1536-5166 (electronic) |
DOI: | 10.1097/WNO.0000000000000596 |
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